Targeted delivery of mannosylated-PLGA nanoparticles of antiretroviral drug to brain

Bhavin K Patel, Rajesh H Parikh, Nilesh Patel Department of Pharmaceutics and Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, Gujarat, India Abstract: Mannosylated polymeric nanoparticles (NPs) enable improvement of brain bioav...

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Autores principales:	Patel BK, Parikh RH, Patel N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Mannosylated PLGA Nanoparticles Brain Targeting Macrophage Targeting HIV (Human Immune Deficiency Virus) Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f381f74368bc499689d9a8401917d6f3
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spelling	oai:doaj.org-article:f381f74368bc499689d9a8401917d6f32021-12-02T07:45:56ZTargeted delivery of mannosylated-PLGA nanoparticles of antiretroviral drug to brain1178-2013https://doaj.org/article/f381f74368bc499689d9a8401917d6f32018-03-01T00:00:00Zhttps://www.dovepress.com/targeted-delivery-of-mannosylated-plga-nanoparticles-of-anti-retrovira-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Bhavin K Patel, Rajesh H Parikh, Nilesh Patel Department of Pharmaceutics and Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, Gujarat, India Abstract: Mannosylated polymeric nanoparticles (NPs) enable improvement of brain bioavailability and reduction of dosing due to efficient drug delivery at the target site. Mannose receptors are present on the surface of macrophages, and therefore, in this study, it is expected that mannosylated NPs of anti-human immunodeficiency virus drug may target the macrophages, which may improve the therapeutic outcome and reduce the toxicity of antiretroviral bioactives. Poly(lactic-co-glycolic acid) (PLGA) and mannosylated-PLGA NPs (Mn-PLGA NPs) were prepared and administered by intravenous route in a dose of 10 mg/kg. After predetermined time period, the pharmacokinetics and biodistribution of NPs were analyzed using high-performance liquid chromatography and confocal microscopy, respectively. Results of this study indicated that Mn-PLGA NPs would be a promising therapeutic system for efficient delivery of the drug into brain macrophages. Keywords: mannosylated poly(lactic-co-glycolic acid) nanoparticles, brain targeting, macrophage targeting, human immunodeficiency virusPatel BKParikh RHPatel NDove Medical PressarticleMannosylated PLGA NanoparticlesBrain TargetingMacrophage TargetingHIV (Human Immune Deficiency Virus)Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 97-100 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mannosylated PLGA Nanoparticles Brain Targeting Macrophage Targeting HIV (Human Immune Deficiency Virus) Medicine (General) R5-920
spellingShingle	Mannosylated PLGA Nanoparticles Brain Targeting Macrophage Targeting HIV (Human Immune Deficiency Virus) Medicine (General) R5-920 Patel BK Parikh RH Patel N Targeted delivery of mannosylated-PLGA nanoparticles of antiretroviral drug to brain
description	Bhavin K Patel, Rajesh H Parikh, Nilesh Patel Department of Pharmaceutics and Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, Gujarat, India Abstract: Mannosylated polymeric nanoparticles (NPs) enable improvement of brain bioavailability and reduction of dosing due to efficient drug delivery at the target site. Mannose receptors are present on the surface of macrophages, and therefore, in this study, it is expected that mannosylated NPs of anti-human immunodeficiency virus drug may target the macrophages, which may improve the therapeutic outcome and reduce the toxicity of antiretroviral bioactives. Poly(lactic-co-glycolic acid) (PLGA) and mannosylated-PLGA NPs (Mn-PLGA NPs) were prepared and administered by intravenous route in a dose of 10 mg/kg. After predetermined time period, the pharmacokinetics and biodistribution of NPs were analyzed using high-performance liquid chromatography and confocal microscopy, respectively. Results of this study indicated that Mn-PLGA NPs would be a promising therapeutic system for efficient delivery of the drug into brain macrophages. Keywords: mannosylated poly(lactic-co-glycolic acid) nanoparticles, brain targeting, macrophage targeting, human immunodeficiency virus
format	article
author	Patel BK Parikh RH Patel N
author_facet	Patel BK Parikh RH Patel N
author_sort	Patel BK
title	Targeted delivery of mannosylated-PLGA nanoparticles of antiretroviral drug to brain
title_short	Targeted delivery of mannosylated-PLGA nanoparticles of antiretroviral drug to brain
title_full	Targeted delivery of mannosylated-PLGA nanoparticles of antiretroviral drug to brain
title_fullStr	Targeted delivery of mannosylated-PLGA nanoparticles of antiretroviral drug to brain
title_full_unstemmed	Targeted delivery of mannosylated-PLGA nanoparticles of antiretroviral drug to brain
title_sort	targeted delivery of mannosylated-plga nanoparticles of antiretroviral drug to brain
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f381f74368bc499689d9a8401917d6f3
work_keys_str_mv	AT patelbk targeteddeliveryofmannosylatedplgananoparticlesofantiretroviraldrugtobrain AT parikhrh targeteddeliveryofmannosylatedplgananoparticlesofantiretroviraldrugtobrain AT pateln targeteddeliveryofmannosylatedplgananoparticlesofantiretroviraldrugtobrain
_version_	1718399195048574976

Targeted delivery of mannosylated-PLGA nanoparticles of antiretroviral drug to brain

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