Echinochrome pigment attenuates diabetic nephropathy in the models of type 1 and type 2 diabetes

Background. The main complication of diabetes mellitus is diabetic nephropathy in both types, which is a main reason for renal failure. Echinochrome substance present in sea urchin shells and spines and possesses high antioxidant activity.Aim. is to evaluate the ability of Ech to suppress the progre...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Amel Mahmoud Soliman, Ayman Saber Mohamed, Mohamed-Assem Said Marie
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2016
Materias:	diabetes mellitus echinochrome- nephropathy oxidative stress kidney Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/f383f94c8dbb47c391499b25d648a74b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f383f94c8dbb47c391499b25d648a74b
record_format	dspace
spelling	oai:doaj.org-article:f383f94c8dbb47c391499b25d648a74b2021-11-14T09:00:20ZEchinochrome pigment attenuates diabetic nephropathy in the models of type 1 and type 2 diabetes2072-03512072-037810.14341/DM8039https://doaj.org/article/f383f94c8dbb47c391499b25d648a74b2016-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/8039https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Background. The main complication of diabetes mellitus is diabetic nephropathy in both types, which is a main reason for renal failure. Echinochrome substance present in sea urchin shells and spines and possesses high antioxidant activity.Aim. is to evaluate the ability of Ech to suppress the progression of diabetic complication in kidney.Materials and methods. Thirty-six male Wistar albino rats were divided into two main groups, type 1 diabetes mellitus and type 2 diabetes mellitus. Both groups divided into control, diabetic and echinochrome subgroups. Type 1 diabetes was induced by single dose of streptozotocin (60 mg/kg, i.p), while type 2 was induced by high fat diet for 4 weeks before the injection with streptozotocin (30 mg/kg, i.p). The treated groups were administrated by echinochrome (1mg/kg body weight in 10% DMSO) daily for 4 weeks.Results. Echinochrome groups showed reduction in the concentrations of glucose, malondialdehyde, urea, uric acid and creatinine. While it caused general increase in glutathione-S-transferase, superoxide dismutase, catalase, glutathione reduced, nitric oxide and creatinine clearance. The histopathological investigation showed clear improvement in the kidney architecture.Conclusion. Administration of echinochrome improves renal function and ameliorates renal histopathological changes possibly by improvement of glucose metabolism and inhibition of lipid peroxidation process.Amel Mahmoud SolimanAyman Saber MohamedMohamed-Assem Said MarieEndocrinology Research Centrearticlediabetes mellitusechinochrome- nephropathyoxidative stresskidneyNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 19, Iss 6, Pp 464-470 (2016)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus echinochrome- nephropathy oxidative stress kidney Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus echinochrome- nephropathy oxidative stress kidney Nutritional diseases. Deficiency diseases RC620-627 Amel Mahmoud Soliman Ayman Saber Mohamed Mohamed-Assem Said Marie Echinochrome pigment attenuates diabetic nephropathy in the models of type 1 and type 2 diabetes
description	Background. The main complication of diabetes mellitus is diabetic nephropathy in both types, which is a main reason for renal failure. Echinochrome substance present in sea urchin shells and spines and possesses high antioxidant activity.Aim. is to evaluate the ability of Ech to suppress the progression of diabetic complication in kidney.Materials and methods. Thirty-six male Wistar albino rats were divided into two main groups, type 1 diabetes mellitus and type 2 diabetes mellitus. Both groups divided into control, diabetic and echinochrome subgroups. Type 1 diabetes was induced by single dose of streptozotocin (60 mg/kg, i.p), while type 2 was induced by high fat diet for 4 weeks before the injection with streptozotocin (30 mg/kg, i.p). The treated groups were administrated by echinochrome (1mg/kg body weight in 10% DMSO) daily for 4 weeks.Results. Echinochrome groups showed reduction in the concentrations of glucose, malondialdehyde, urea, uric acid and creatinine. While it caused general increase in glutathione-S-transferase, superoxide dismutase, catalase, glutathione reduced, nitric oxide and creatinine clearance. The histopathological investigation showed clear improvement in the kidney architecture.Conclusion. Administration of echinochrome improves renal function and ameliorates renal histopathological changes possibly by improvement of glucose metabolism and inhibition of lipid peroxidation process.
format	article
author	Amel Mahmoud Soliman Ayman Saber Mohamed Mohamed-Assem Said Marie
author_facet	Amel Mahmoud Soliman Ayman Saber Mohamed Mohamed-Assem Said Marie
author_sort	Amel Mahmoud Soliman
title	Echinochrome pigment attenuates diabetic nephropathy in the models of type 1 and type 2 diabetes
title_short	Echinochrome pigment attenuates diabetic nephropathy in the models of type 1 and type 2 diabetes
title_full	Echinochrome pigment attenuates diabetic nephropathy in the models of type 1 and type 2 diabetes
title_fullStr	Echinochrome pigment attenuates diabetic nephropathy in the models of type 1 and type 2 diabetes
title_full_unstemmed	Echinochrome pigment attenuates diabetic nephropathy in the models of type 1 and type 2 diabetes
title_sort	echinochrome pigment attenuates diabetic nephropathy in the models of type 1 and type 2 diabetes
publisher	Endocrinology Research Centre
publishDate	2016
url	https://doaj.org/article/f383f94c8dbb47c391499b25d648a74b
work_keys_str_mv	AT amelmahmoudsoliman echinochromepigmentattenuatesdiabeticnephropathyinthemodelsoftype1andtype2diabetes AT aymansabermohamed echinochromepigmentattenuatesdiabeticnephropathyinthemodelsoftype1andtype2diabetes AT mohamedassemsaidmarie echinochromepigmentattenuatesdiabeticnephropathyinthemodelsoftype1andtype2diabetes
_version_	1718429564883959808

Echinochrome pigment attenuates diabetic nephropathy in the models of type 1 and type 2 diabetes

Ejemplares similares