The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation

Beta-adrenergic stimulation of brown adipose tissue leads to thermogenesis via the activating transcription factor 2 (ATF2) mediated expression of the thermogenic genes Ucp1 and Pgc-1α. Here, the authors show that the scaffold protein p62 regulates brown adipose tissue function through modifying ATF...

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Autores principales:	Katrin Fischer, Anna Fenzl, Dianxin Liu, Kenneth A. Dyar, Maximilian Kleinert, Markus Brielmeier, Christoffer Clemmensen, Anna Fedl, Brian Finan, Andre Gessner, Martin Jastroch, Jianfeng Huang, Susanne Keipert, Martin Klingenspor, Jens C. Brüning, Manfred Kneilling, Florian C. Maier, Ahmed E. Othman, Bernd J. Pichler, Ines Pramme-Steinwachs, Stephan Sachs, Angelika Scheideler, Wolfgang M. Thaiss, Henriette Uhlenhaut, Siegfried Ussar, Stephen C. Woods, Julia Zorn, Kerstin Stemmer, Sheila Collins, Maria Diaz-Meco, Jorge Moscat, Matthias H. Tschöp, Timo D. Müller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f38460b423054ee680f7224c62a860c9
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spelling	oai:doaj.org-article:f38460b423054ee680f7224c62a860c92021-12-02T17:32:57ZThe scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation10.1038/s41467-020-16230-82041-1723https://doaj.org/article/f38460b423054ee680f7224c62a860c92020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16230-8https://doaj.org/toc/2041-1723Beta-adrenergic stimulation of brown adipose tissue leads to thermogenesis via the activating transcription factor 2 (ATF2) mediated expression of the thermogenic genes Ucp1 and Pgc-1α. Here, the authors show that the scaffold protein p62 regulates brown adipose tissue function through modifying ATF2 genomic binding and subsequent Ucp1 and Pgc-1α induction.Katrin FischerAnna FenzlDianxin LiuKenneth A. DyarMaximilian KleinertMarkus BrielmeierChristoffer ClemmensenAnna FedlBrian FinanAndre GessnerMartin JastrochJianfeng HuangSusanne KeipertMartin KlingensporJens C. BrüningManfred KneillingFlorian C. MaierAhmed E. OthmanBernd J. PichlerInes Pramme-SteinwachsStephan SachsAngelika ScheidelerWolfgang M. ThaissHenriette UhlenhautSiegfried UssarStephen C. WoodsJulia ZornKerstin StemmerSheila CollinsMaria Diaz-MecoJorge MoscatMatthias H. TschöpTimo D. MüllerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katrin Fischer Anna Fenzl Dianxin Liu Kenneth A. Dyar Maximilian Kleinert Markus Brielmeier Christoffer Clemmensen Anna Fedl Brian Finan Andre Gessner Martin Jastroch Jianfeng Huang Susanne Keipert Martin Klingenspor Jens C. Brüning Manfred Kneilling Florian C. Maier Ahmed E. Othman Bernd J. Pichler Ines Pramme-Steinwachs Stephan Sachs Angelika Scheideler Wolfgang M. Thaiss Henriette Uhlenhaut Siegfried Ussar Stephen C. Woods Julia Zorn Kerstin Stemmer Sheila Collins Maria Diaz-Meco Jorge Moscat Matthias H. Tschöp Timo D. Müller The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation
description	Beta-adrenergic stimulation of brown adipose tissue leads to thermogenesis via the activating transcription factor 2 (ATF2) mediated expression of the thermogenic genes Ucp1 and Pgc-1α. Here, the authors show that the scaffold protein p62 regulates brown adipose tissue function through modifying ATF2 genomic binding and subsequent Ucp1 and Pgc-1α induction.
format	article
author	Katrin Fischer Anna Fenzl Dianxin Liu Kenneth A. Dyar Maximilian Kleinert Markus Brielmeier Christoffer Clemmensen Anna Fedl Brian Finan Andre Gessner Martin Jastroch Jianfeng Huang Susanne Keipert Martin Klingenspor Jens C. Brüning Manfred Kneilling Florian C. Maier Ahmed E. Othman Bernd J. Pichler Ines Pramme-Steinwachs Stephan Sachs Angelika Scheideler Wolfgang M. Thaiss Henriette Uhlenhaut Siegfried Ussar Stephen C. Woods Julia Zorn Kerstin Stemmer Sheila Collins Maria Diaz-Meco Jorge Moscat Matthias H. Tschöp Timo D. Müller
author_facet	Katrin Fischer Anna Fenzl Dianxin Liu Kenneth A. Dyar Maximilian Kleinert Markus Brielmeier Christoffer Clemmensen Anna Fedl Brian Finan Andre Gessner Martin Jastroch Jianfeng Huang Susanne Keipert Martin Klingenspor Jens C. Brüning Manfred Kneilling Florian C. Maier Ahmed E. Othman Bernd J. Pichler Ines Pramme-Steinwachs Stephan Sachs Angelika Scheideler Wolfgang M. Thaiss Henriette Uhlenhaut Siegfried Ussar Stephen C. Woods Julia Zorn Kerstin Stemmer Sheila Collins Maria Diaz-Meco Jorge Moscat Matthias H. Tschöp Timo D. Müller
author_sort	Katrin Fischer
title	The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation
title_short	The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation
title_full	The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation
title_fullStr	The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation
title_full_unstemmed	The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation
title_sort	scaffold protein p62 regulates adaptive thermogenesis through atf2 nuclear target activation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f38460b423054ee680f7224c62a860c9
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The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation

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