Spatially interacting phosphorylation sites and mutations in cancer

Dysregulated phosphorylation is well-known in cancers, but it has largely been studied in isolation from mutations. Here the authors introduce HotPho, a tool that can discover spatial interactions between phosphosites and mutations, which are associated with activating mutation and genetic dependenc...

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Autores principales:	Kuan-lin Huang, Adam D. Scott, Daniel Cui Zhou, Liang-Bo Wang, Amila Weerasinghe, Abdulkadir Elmas, Ruiyang Liu, Yige Wu, Michael C. Wendl, Matthew A. Wyczalkowski, Jessika Baral, Sohini Sengupta, Chin-Wen Lai, Kelly Ruggles, Samuel H. Payne, Benjamin Raphael, David Fenyö, Ken Chen, Gordon Mills, Li Ding
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f38865e7329d4929ad5179de6e149dde
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spelling	oai:doaj.org-article:f38865e7329d4929ad5179de6e149dde2021-12-02T16:45:10ZSpatially interacting phosphorylation sites and mutations in cancer10.1038/s41467-021-22481-w2041-1723https://doaj.org/article/f38865e7329d4929ad5179de6e149dde2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22481-whttps://doaj.org/toc/2041-1723Dysregulated phosphorylation is well-known in cancers, but it has largely been studied in isolation from mutations. Here the authors introduce HotPho, a tool that can discover spatial interactions between phosphosites and mutations, which are associated with activating mutation and genetic dependencies in cancer.Kuan-lin HuangAdam D. ScottDaniel Cui ZhouLiang-Bo WangAmila WeerasingheAbdulkadir ElmasRuiyang LiuYige WuMichael C. WendlMatthew A. WyczalkowskiJessika BaralSohini SenguptaChin-Wen LaiKelly RugglesSamuel H. PayneBenjamin RaphaelDavid FenyöKen ChenGordon MillsLi DingNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kuan-lin Huang Adam D. Scott Daniel Cui Zhou Liang-Bo Wang Amila Weerasinghe Abdulkadir Elmas Ruiyang Liu Yige Wu Michael C. Wendl Matthew A. Wyczalkowski Jessika Baral Sohini Sengupta Chin-Wen Lai Kelly Ruggles Samuel H. Payne Benjamin Raphael David Fenyö Ken Chen Gordon Mills Li Ding Spatially interacting phosphorylation sites and mutations in cancer
description	Dysregulated phosphorylation is well-known in cancers, but it has largely been studied in isolation from mutations. Here the authors introduce HotPho, a tool that can discover spatial interactions between phosphosites and mutations, which are associated with activating mutation and genetic dependencies in cancer.
format	article
author	Kuan-lin Huang Adam D. Scott Daniel Cui Zhou Liang-Bo Wang Amila Weerasinghe Abdulkadir Elmas Ruiyang Liu Yige Wu Michael C. Wendl Matthew A. Wyczalkowski Jessika Baral Sohini Sengupta Chin-Wen Lai Kelly Ruggles Samuel H. Payne Benjamin Raphael David Fenyö Ken Chen Gordon Mills Li Ding
author_facet	Kuan-lin Huang Adam D. Scott Daniel Cui Zhou Liang-Bo Wang Amila Weerasinghe Abdulkadir Elmas Ruiyang Liu Yige Wu Michael C. Wendl Matthew A. Wyczalkowski Jessika Baral Sohini Sengupta Chin-Wen Lai Kelly Ruggles Samuel H. Payne Benjamin Raphael David Fenyö Ken Chen Gordon Mills Li Ding
author_sort	Kuan-lin Huang
title	Spatially interacting phosphorylation sites and mutations in cancer
title_short	Spatially interacting phosphorylation sites and mutations in cancer
title_full	Spatially interacting phosphorylation sites and mutations in cancer
title_fullStr	Spatially interacting phosphorylation sites and mutations in cancer
title_full_unstemmed	Spatially interacting phosphorylation sites and mutations in cancer
title_sort	spatially interacting phosphorylation sites and mutations in cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f38865e7329d4929ad5179de6e149dde
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Spatially interacting phosphorylation sites and mutations in cancer

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