Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs

Shasha Rao, Yunmei Song, Frank Peddie, Allan M EvansSansom Institute for Health Research, Division of Health Sciences, University of South Australia, Adelaide, South Australia, AustraliaAbstract: Poorly water-soluble drugs, such as phenylephrine, offer challenging problems for buccal drug delivery....

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Autores principales:	Rao S, Song Y, Peddie F, Evans AM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f38bbf558dce4e65a046cf319afb0c5b
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spelling	oai:doaj.org-article:f38bbf558dce4e65a046cf319afb0c5b2021-12-02T05:49:32ZParticle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs1176-91141178-2013https://doaj.org/article/f38bbf558dce4e65a046cf319afb0c5b2011-06-01T00:00:00Zhttp://www.dovepress.com/particle-size-reduction-to-the-nanometer-range-a-promising-approach-to-a7683https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Shasha Rao, Yunmei Song, Frank Peddie, Allan M EvansSansom Institute for Health Research, Division of Health Sciences, University of South Australia, Adelaide, South Australia, AustraliaAbstract: Poorly water-soluble drugs, such as phenylephrine, offer challenging problems for buccal drug delivery. In order to overcome these problems, particle size reduction (to the nanometer range) and cyclodextrin complexation were investigated for permeability enhancement. The apparent solubility in water and the buccal permeation of the original phenylephrine coarse powder, a phenylephrine&ndash;cyclodextrin complex and phenylephrine nanosuspensions were &shy;characterized. The particle size and particle surface properties of phenylephrine nanosuspensions were used to optimize the size reduction process. The optimized phenylephrine nanosuspension was then freeze dried and incorporated into a multi-layered buccal patch, consisting of a small tablet adhered to a mucoadhesive film, yielding a phenylephrine buccal product with good dosage accuracy and improved mucosal permeability. The design of the buccal patch allows for drug incorporation without the need to change the mucoadhesive component, and is potentially suited to a range of poorly water-soluble compounds.Keywords: buccal drug delivery, nanosuspension, solubility, permeation enhancement, mucoadhesionRao SSong YPeddie FEvans AMDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1245-1251 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Rao S Song Y Peddie F Evans AM Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs
description	Shasha Rao, Yunmei Song, Frank Peddie, Allan M EvansSansom Institute for Health Research, Division of Health Sciences, University of South Australia, Adelaide, South Australia, AustraliaAbstract: Poorly water-soluble drugs, such as phenylephrine, offer challenging problems for buccal drug delivery. In order to overcome these problems, particle size reduction (to the nanometer range) and cyclodextrin complexation were investigated for permeability enhancement. The apparent solubility in water and the buccal permeation of the original phenylephrine coarse powder, a phenylephrine&ndash;cyclodextrin complex and phenylephrine nanosuspensions were &shy;characterized. The particle size and particle surface properties of phenylephrine nanosuspensions were used to optimize the size reduction process. The optimized phenylephrine nanosuspension was then freeze dried and incorporated into a multi-layered buccal patch, consisting of a small tablet adhered to a mucoadhesive film, yielding a phenylephrine buccal product with good dosage accuracy and improved mucosal permeability. The design of the buccal patch allows for drug incorporation without the need to change the mucoadhesive component, and is potentially suited to a range of poorly water-soluble compounds.Keywords: buccal drug delivery, nanosuspension, solubility, permeation enhancement, mucoadhesion
format	article
author	Rao S Song Y Peddie F Evans AM
author_facet	Rao S Song Y Peddie F Evans AM
author_sort	Rao S
title	Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs
title_short	Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs
title_full	Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs
title_fullStr	Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs
title_full_unstemmed	Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs
title_sort	particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/f38bbf558dce4e65a046cf319afb0c5b
work_keys_str_mv	AT raos particlesizereductiontothenanometerrangeapromisingapproachtoimprovebuccalabsorptionofpoorlywatersolubledrugs AT songy particlesizereductiontothenanometerrangeapromisingapproachtoimprovebuccalabsorptionofpoorlywatersolubledrugs AT peddief particlesizereductiontothenanometerrangeapromisingapproachtoimprovebuccalabsorptionofpoorlywatersolubledrugs AT evansam particlesizereductiontothenanometerrangeapromisingapproachtoimprovebuccalabsorptionofpoorlywatersolubledrugs
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Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs

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