Integrated genetic and epigenetic analysis of myxofibrosarcoma

Integrated genetic and epigenetic analysis of myxofibrosarcoma

Myxofibrosarcoma occurs in adults and is associated with high local relapse. Here, based on exome/transcriptome sequencing and DNA methylation analysis, the authors identify driver genes and methylation clusters associated with unique combinations of mutations, outcomes, and immune cell compositions...

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Autores principales: Koichi Ogura, Fumie Hosoda, Yasuhito Arai, Hiromi Nakamura, Natsuko Hama, Yasushi Totoki, Akihiko Yoshida, Momoko Nagai, Mamoru Kato, Erika Arakawa, Wakako Mukai, Hirofumi Rokutan, Akira Kawai, Sakae Tanaka, Tatsuhiro Shibata
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/f38d14ba97c849c9b84a8c13e9c3779d
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spelling oai:doaj.org-article:f38d14ba97c849c9b84a8c13e9c3779d2021-12-02T17:32:48ZIntegrated genetic and epigenetic analysis of myxofibrosarcoma10.1038/s41467-018-03891-92041-1723https://doaj.org/article/f38d14ba97c849c9b84a8c13e9c3779d2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03891-9https://doaj.org/toc/2041-1723Myxofibrosarcoma occurs in adults and is associated with high local relapse. Here, based on exome/transcriptome sequencing and DNA methylation analysis, the authors identify driver genes and methylation clusters associated with unique combinations of mutations, outcomes, and immune cell compositions.Koichi OguraFumie HosodaYasuhito AraiHiromi NakamuraNatsuko HamaYasushi TotokiAkihiko YoshidaMomoko NagaiMamoru KatoErika ArakawaWakako MukaiHirofumi RokutanAkira KawaiSakae TanakaTatsuhiro ShibataNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Koichi Ogura
Fumie Hosoda
Yasuhito Arai
Hiromi Nakamura
Natsuko Hama
Yasushi Totoki
Akihiko Yoshida
Momoko Nagai
Mamoru Kato
Erika Arakawa
Wakako Mukai
Hirofumi Rokutan
Akira Kawai
Sakae Tanaka
Tatsuhiro Shibata
Integrated genetic and epigenetic analysis of myxofibrosarcoma
description Myxofibrosarcoma occurs in adults and is associated with high local relapse. Here, based on exome/transcriptome sequencing and DNA methylation analysis, the authors identify driver genes and methylation clusters associated with unique combinations of mutations, outcomes, and immune cell compositions.
format article
author Koichi Ogura
Fumie Hosoda
Yasuhito Arai
Hiromi Nakamura
Natsuko Hama
Yasushi Totoki
Akihiko Yoshida
Momoko Nagai
Mamoru Kato
Erika Arakawa
Wakako Mukai
Hirofumi Rokutan
Akira Kawai
Sakae Tanaka
Tatsuhiro Shibata
author_facet Koichi Ogura
Fumie Hosoda
Yasuhito Arai
Hiromi Nakamura
Natsuko Hama
Yasushi Totoki
Akihiko Yoshida
Momoko Nagai
Mamoru Kato
Erika Arakawa
Wakako Mukai
Hirofumi Rokutan
Akira Kawai
Sakae Tanaka
Tatsuhiro Shibata
author_sort Koichi Ogura
title Integrated genetic and epigenetic analysis of myxofibrosarcoma
title_short Integrated genetic and epigenetic analysis of myxofibrosarcoma
title_full Integrated genetic and epigenetic analysis of myxofibrosarcoma
title_fullStr Integrated genetic and epigenetic analysis of myxofibrosarcoma
title_full_unstemmed Integrated genetic and epigenetic analysis of myxofibrosarcoma
title_sort integrated genetic and epigenetic analysis of myxofibrosarcoma
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/f38d14ba97c849c9b84a8c13e9c3779d
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