Cadherin-11 regulates motility in normal cortical neural precursors and glioblastoma.

Metastasizing tumor cells undergo a transformation that resembles a process in normal development when non-migratory epithelial cells modulate the expression of cytoskeletal and adhesion proteins to promote cell motility. Here we find a mesenchymal cadherin, Cadherin-11 (CDH11), is increased in cell...

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Autores principales:	Jessica D Schulte, Maya Srikanth, Sunit Das, Jianing Zhang, Justin D Lathia, Lihui Yin, Jeremy N Rich, Eric C Olson, John A Kessler, Anjen Chenn
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f3916978a33a4f88ba4791c5f7797657
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spelling	oai:doaj.org-article:f3916978a33a4f88ba4791c5f77976572021-11-18T09:00:45ZCadherin-11 regulates motility in normal cortical neural precursors and glioblastoma.1932-620310.1371/journal.pone.0070962https://doaj.org/article/f3916978a33a4f88ba4791c5f77976572013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23951053/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Metastasizing tumor cells undergo a transformation that resembles a process in normal development when non-migratory epithelial cells modulate the expression of cytoskeletal and adhesion proteins to promote cell motility. Here we find a mesenchymal cadherin, Cadherin-11 (CDH11), is increased in cells exiting the ventricular zone (VZ) neuroepithelium during normal cerebral cortical development. When overexpressed in cortical progenitors in vivo, CDH11 causes premature exit from the neuroepithelium and increased cell migration. CDH11 expression is elevated in human brain tumors, correlating with higher tumor grade and decreased patient survival. In glioblastoma, CDH11-expressing tumor cells can be found localized near tumor vasculature. Endothelial cells stimulate TGFβ signaling and CDH11 expression in glioblastoma cells. TGFβ promotes glioblastoma cell motility, and knockdown of CDH11 expression in primary human glioblastoma cells inhibits TGFβ-stimulated migration. Together, these findings show that Cadherin-11 can promote cell migration in neural precursors and glioblastoma cells and suggest that endothelial cells increase tumor aggressiveness by co-opting mechanisms that regulate normal neural development.Jessica D SchulteMaya SrikanthSunit DasJianing ZhangJustin D LathiaLihui YinJeremy N RichEric C OlsonJohn A KesslerAnjen ChennPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e70962 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jessica D Schulte Maya Srikanth Sunit Das Jianing Zhang Justin D Lathia Lihui Yin Jeremy N Rich Eric C Olson John A Kessler Anjen Chenn Cadherin-11 regulates motility in normal cortical neural precursors and glioblastoma.
description	Metastasizing tumor cells undergo a transformation that resembles a process in normal development when non-migratory epithelial cells modulate the expression of cytoskeletal and adhesion proteins to promote cell motility. Here we find a mesenchymal cadherin, Cadherin-11 (CDH11), is increased in cells exiting the ventricular zone (VZ) neuroepithelium during normal cerebral cortical development. When overexpressed in cortical progenitors in vivo, CDH11 causes premature exit from the neuroepithelium and increased cell migration. CDH11 expression is elevated in human brain tumors, correlating with higher tumor grade and decreased patient survival. In glioblastoma, CDH11-expressing tumor cells can be found localized near tumor vasculature. Endothelial cells stimulate TGFβ signaling and CDH11 expression in glioblastoma cells. TGFβ promotes glioblastoma cell motility, and knockdown of CDH11 expression in primary human glioblastoma cells inhibits TGFβ-stimulated migration. Together, these findings show that Cadherin-11 can promote cell migration in neural precursors and glioblastoma cells and suggest that endothelial cells increase tumor aggressiveness by co-opting mechanisms that regulate normal neural development.
format	article
author	Jessica D Schulte Maya Srikanth Sunit Das Jianing Zhang Justin D Lathia Lihui Yin Jeremy N Rich Eric C Olson John A Kessler Anjen Chenn
author_facet	Jessica D Schulte Maya Srikanth Sunit Das Jianing Zhang Justin D Lathia Lihui Yin Jeremy N Rich Eric C Olson John A Kessler Anjen Chenn
author_sort	Jessica D Schulte
title	Cadherin-11 regulates motility in normal cortical neural precursors and glioblastoma.
title_short	Cadherin-11 regulates motility in normal cortical neural precursors and glioblastoma.
title_full	Cadherin-11 regulates motility in normal cortical neural precursors and glioblastoma.
title_fullStr	Cadherin-11 regulates motility in normal cortical neural precursors and glioblastoma.
title_full_unstemmed	Cadherin-11 regulates motility in normal cortical neural precursors and glioblastoma.
title_sort	cadherin-11 regulates motility in normal cortical neural precursors and glioblastoma.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f3916978a33a4f88ba4791c5f7797657
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Cadherin-11 regulates motility in normal cortical neural precursors and glioblastoma.

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