Autoantibody profiles and clinical association in Thai patients with autoimmune retinopathy

Abstract Autoimmune retinopathy (AIR) is a rare immune-mediated inflammation of the retina. The autoantibodies against retinal proteins and glycolytic enzymes were reported to be involved in the pathogenesis. This retrospective cohort study assessed the antiretinal autoantibody profiles and their as...

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Autores principales:	Aulia Rahmi Pawestri, Niracha Arjkongharn, Ragkit Suvannaboon, Aekkachai Tuekprakhon, Vichien Srimuninnimit, Suthipol Udompunthurak, La-ongsri Atchaneeyasakul, Ajchara Koolvisoot, Adisak Trinavarat
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f3966f32f8cd438bbabeca4a7dca4e9f
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spelling	oai:doaj.org-article:f3966f32f8cd438bbabeca4a7dca4e9f2021-12-02T16:17:28ZAutoantibody profiles and clinical association in Thai patients with autoimmune retinopathy10.1038/s41598-021-94377-02045-2322https://doaj.org/article/f3966f32f8cd438bbabeca4a7dca4e9f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94377-0https://doaj.org/toc/2045-2322Abstract Autoimmune retinopathy (AIR) is a rare immune-mediated inflammation of the retina. The autoantibodies against retinal proteins and glycolytic enzymes were reported to be involved in the pathogenesis. This retrospective cohort study assessed the antiretinal autoantibody profiles and their association with clinical outcomes of AIR patients in Thailand. We included 44 patients, 75% were females, with the overall median age of onset of 48 (17–74, IQR 40–55.5) years. Common clinical presentations were nyctalopia (65.9%), blurred vision (52.3%), constricted visual field (43.2%), and nonrecordable electroretinography (65.9%). Underlying malignancy and autoimmune diseases were found in 2 and 12 female patients, respectively. We found 41 autoantibodies, with anti-α-enolase (65.9%) showing the highest prevalence, followed by anti-CAII (43.2%), anti-aldolase (40.9%), and anti-GAPDH (36.4%). Anti-aldolase was associated with male gender (P = 0.012, OR 7.11, 95% CI 1.54–32.91). Anti-CAII showed significant association with age of onset (P = 0.025, 95% CI − 17.28 to − 1.24), while anti-α-enolase (P = 0.002, OR 4.37, 95% CI 1.83–10.37) and anti-GAPDH (P = 0.001, OR 1.87, 95% CI 1.32–2.64) were significantly associated with nonrecordable electroretinography. Association between the antibody profiles and clinical outcomes may be used to direct and adjust the treatment plans and provide insights in the pathogenesis of AIR.Aulia Rahmi PawestriNiracha ArjkongharnRagkit SuvannaboonAekkachai TuekprakhonVichien SrimuninnimitSuthipol UdompunthurakLa-ongsri AtchaneeyasakulAjchara KoolvisootAdisak TrinavaratNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aulia Rahmi Pawestri Niracha Arjkongharn Ragkit Suvannaboon Aekkachai Tuekprakhon Vichien Srimuninnimit Suthipol Udompunthurak La-ongsri Atchaneeyasakul Ajchara Koolvisoot Adisak Trinavarat Autoantibody profiles and clinical association in Thai patients with autoimmune retinopathy
description	Abstract Autoimmune retinopathy (AIR) is a rare immune-mediated inflammation of the retina. The autoantibodies against retinal proteins and glycolytic enzymes were reported to be involved in the pathogenesis. This retrospective cohort study assessed the antiretinal autoantibody profiles and their association with clinical outcomes of AIR patients in Thailand. We included 44 patients, 75% were females, with the overall median age of onset of 48 (17–74, IQR 40–55.5) years. Common clinical presentations were nyctalopia (65.9%), blurred vision (52.3%), constricted visual field (43.2%), and nonrecordable electroretinography (65.9%). Underlying malignancy and autoimmune diseases were found in 2 and 12 female patients, respectively. We found 41 autoantibodies, with anti-α-enolase (65.9%) showing the highest prevalence, followed by anti-CAII (43.2%), anti-aldolase (40.9%), and anti-GAPDH (36.4%). Anti-aldolase was associated with male gender (P = 0.012, OR 7.11, 95% CI 1.54–32.91). Anti-CAII showed significant association with age of onset (P = 0.025, 95% CI − 17.28 to − 1.24), while anti-α-enolase (P = 0.002, OR 4.37, 95% CI 1.83–10.37) and anti-GAPDH (P = 0.001, OR 1.87, 95% CI 1.32–2.64) were significantly associated with nonrecordable electroretinography. Association between the antibody profiles and clinical outcomes may be used to direct and adjust the treatment plans and provide insights in the pathogenesis of AIR.
format	article
author	Aulia Rahmi Pawestri Niracha Arjkongharn Ragkit Suvannaboon Aekkachai Tuekprakhon Vichien Srimuninnimit Suthipol Udompunthurak La-ongsri Atchaneeyasakul Ajchara Koolvisoot Adisak Trinavarat
author_facet	Aulia Rahmi Pawestri Niracha Arjkongharn Ragkit Suvannaboon Aekkachai Tuekprakhon Vichien Srimuninnimit Suthipol Udompunthurak La-ongsri Atchaneeyasakul Ajchara Koolvisoot Adisak Trinavarat
author_sort	Aulia Rahmi Pawestri
title	Autoantibody profiles and clinical association in Thai patients with autoimmune retinopathy
title_short	Autoantibody profiles and clinical association in Thai patients with autoimmune retinopathy
title_full	Autoantibody profiles and clinical association in Thai patients with autoimmune retinopathy
title_fullStr	Autoantibody profiles and clinical association in Thai patients with autoimmune retinopathy
title_full_unstemmed	Autoantibody profiles and clinical association in Thai patients with autoimmune retinopathy
title_sort	autoantibody profiles and clinical association in thai patients with autoimmune retinopathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f3966f32f8cd438bbabeca4a7dca4e9f
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Autoantibody profiles and clinical association in Thai patients with autoimmune retinopathy

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