A prototype device of microliter volume voltammetric pH sensor based on carbazole–quinone redox-probe tethered MWCNT modified three-in-one screen-printed electrode

Abstract As an alternate for the conventional glass-based pH sensor which is associated with problems like fragile nature, alkaline error, and potential drift, the development of a new redox-sensitive pH probe-modified electrode that could show potential, current-drift and surface-fouling free volta...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sakthivel Srinivas, Krishnan Ashokkumar, Kamaraj Sriraghavan, Annamalai Senthil Kumar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f397a541fd36477dae278f12c2d59b1c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f397a541fd36477dae278f12c2d59b1c
record_format	dspace
spelling	oai:doaj.org-article:f397a541fd36477dae278f12c2d59b1c2021-12-02T18:34:06ZA prototype device of microliter volume voltammetric pH sensor based on carbazole–quinone redox-probe tethered MWCNT modified three-in-one screen-printed electrode10.1038/s41598-021-93368-52045-2322https://doaj.org/article/f397a541fd36477dae278f12c2d59b1c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93368-5https://doaj.org/toc/2045-2322Abstract As an alternate for the conventional glass-based pH sensor which is associated with problems like fragile nature, alkaline error, and potential drift, the development of a new redox-sensitive pH probe-modified electrode that could show potential, current-drift and surface-fouling free voltammetric pH sensing is a demanding research interest, recently. Herein, we report a substituted carbazole-quinone (Car-HQ) based new redox-active pH-sensitive probe that contains benzyl and bromo-substituents, immobilized multiwalled carbon nanotube modified glassy carbon (GCE/MWCNT@Car-HQ) and screen-printed three-in-one (SPE/MWCNT@Car-HQ) electrodes for selective, surface-fouling free pH sensor application. This new system showed a well-defined surface-confined redox peak at an apparent standard electrode potential, E o′ = − 0.160 V versus Ag/AgCl with surface-excess value, Γ = 47 n mol cm−2 in pH 7 phosphate buffer solution. When tested with various electroactive chemicals and biochemicals such as cysteine, hydrazine, NADH, uric acid, and ascorbic acid, MWCNT@Car-HQ showed an unaltered redox-peak potential and current values without mediated oxidation/reduction behavior unlike the conventional hydroquinone, anthraquinone and other redox mediators based voltammetry sensors with serious electrocatalytic effects and in turn potential and current drifts. A strong π–π interaction, nitrogen-atom assisted surface orientation and C–C bond formation on the graphitic structure of MWCNT are the plausible reasons for stable and selective voltammetric pH sensing application of MWCNT@Car-HQ system. Using a programed/in-built three-in-one screen printed compatible potentiostat system, voltammetric pH sensing of 3 μL sample of urine, saliva, and orange juice samples with pH values comparable to that of milliliter volume-based pH-glass electrode measurements has been demonstrated.Sakthivel SrinivasKrishnan AshokkumarKamaraj SriraghavanAnnamalai Senthil KumarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sakthivel Srinivas Krishnan Ashokkumar Kamaraj Sriraghavan Annamalai Senthil Kumar A prototype device of microliter volume voltammetric pH sensor based on carbazole–quinone redox-probe tethered MWCNT modified three-in-one screen-printed electrode
description	Abstract As an alternate for the conventional glass-based pH sensor which is associated with problems like fragile nature, alkaline error, and potential drift, the development of a new redox-sensitive pH probe-modified electrode that could show potential, current-drift and surface-fouling free voltammetric pH sensing is a demanding research interest, recently. Herein, we report a substituted carbazole-quinone (Car-HQ) based new redox-active pH-sensitive probe that contains benzyl and bromo-substituents, immobilized multiwalled carbon nanotube modified glassy carbon (GCE/MWCNT@Car-HQ) and screen-printed three-in-one (SPE/MWCNT@Car-HQ) electrodes for selective, surface-fouling free pH sensor application. This new system showed a well-defined surface-confined redox peak at an apparent standard electrode potential, E o′ = − 0.160 V versus Ag/AgCl with surface-excess value, Γ = 47 n mol cm−2 in pH 7 phosphate buffer solution. When tested with various electroactive chemicals and biochemicals such as cysteine, hydrazine, NADH, uric acid, and ascorbic acid, MWCNT@Car-HQ showed an unaltered redox-peak potential and current values without mediated oxidation/reduction behavior unlike the conventional hydroquinone, anthraquinone and other redox mediators based voltammetry sensors with serious electrocatalytic effects and in turn potential and current drifts. A strong π–π interaction, nitrogen-atom assisted surface orientation and C–C bond formation on the graphitic structure of MWCNT are the plausible reasons for stable and selective voltammetric pH sensing application of MWCNT@Car-HQ system. Using a programed/in-built three-in-one screen printed compatible potentiostat system, voltammetric pH sensing of 3 μL sample of urine, saliva, and orange juice samples with pH values comparable to that of milliliter volume-based pH-glass electrode measurements has been demonstrated.
format	article
author	Sakthivel Srinivas Krishnan Ashokkumar Kamaraj Sriraghavan Annamalai Senthil Kumar
author_facet	Sakthivel Srinivas Krishnan Ashokkumar Kamaraj Sriraghavan Annamalai Senthil Kumar
author_sort	Sakthivel Srinivas
title	A prototype device of microliter volume voltammetric pH sensor based on carbazole–quinone redox-probe tethered MWCNT modified three-in-one screen-printed electrode
title_short	A prototype device of microliter volume voltammetric pH sensor based on carbazole–quinone redox-probe tethered MWCNT modified three-in-one screen-printed electrode
title_full	A prototype device of microliter volume voltammetric pH sensor based on carbazole–quinone redox-probe tethered MWCNT modified three-in-one screen-printed electrode
title_fullStr	A prototype device of microliter volume voltammetric pH sensor based on carbazole–quinone redox-probe tethered MWCNT modified three-in-one screen-printed electrode
title_full_unstemmed	A prototype device of microliter volume voltammetric pH sensor based on carbazole–quinone redox-probe tethered MWCNT modified three-in-one screen-printed electrode
title_sort	prototype device of microliter volume voltammetric ph sensor based on carbazole–quinone redox-probe tethered mwcnt modified three-in-one screen-printed electrode
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f397a541fd36477dae278f12c2d59b1c
work_keys_str_mv	AT sakthivelsrinivas aprototypedeviceofmicrolitervolumevoltammetricphsensorbasedoncarbazolequinoneredoxprobetetheredmwcntmodifiedthreeinonescreenprintedelectrode AT krishnanashokkumar aprototypedeviceofmicrolitervolumevoltammetricphsensorbasedoncarbazolequinoneredoxprobetetheredmwcntmodifiedthreeinonescreenprintedelectrode AT kamarajsriraghavan aprototypedeviceofmicrolitervolumevoltammetricphsensorbasedoncarbazolequinoneredoxprobetetheredmwcntmodifiedthreeinonescreenprintedelectrode AT annamalaisenthilkumar aprototypedeviceofmicrolitervolumevoltammetricphsensorbasedoncarbazolequinoneredoxprobetetheredmwcntmodifiedthreeinonescreenprintedelectrode AT sakthivelsrinivas prototypedeviceofmicrolitervolumevoltammetricphsensorbasedoncarbazolequinoneredoxprobetetheredmwcntmodifiedthreeinonescreenprintedelectrode AT krishnanashokkumar prototypedeviceofmicrolitervolumevoltammetricphsensorbasedoncarbazolequinoneredoxprobetetheredmwcntmodifiedthreeinonescreenprintedelectrode AT kamarajsriraghavan prototypedeviceofmicrolitervolumevoltammetricphsensorbasedoncarbazolequinoneredoxprobetetheredmwcntmodifiedthreeinonescreenprintedelectrode AT annamalaisenthilkumar prototypedeviceofmicrolitervolumevoltammetricphsensorbasedoncarbazolequinoneredoxprobetetheredmwcntmodifiedthreeinonescreenprintedelectrode
_version_	1718377954802663424

A prototype device of microliter volume voltammetric pH sensor based on carbazole–quinone redox-probe tethered MWCNT modified three-in-one screen-printed electrode

Ejemplares similares