Auditory verbal hallucinations in schizophrenia: current perspectives in brain stimulation treatments

Clément Nathou,1,2 Olivier Etard,2,3 Sonia Dollfus1,21Normandie Univ, UNICAEN, CHU de Caen, Service de Psychiatrie Adulte, Caen, F-14000, France; 2Normandie Univ, UNICAEN, ISTS, EA 7466, GIP Cyceron, Caen 14000, France; 3Normandie Univ, UNICAEN, CHU de Caen, Service des...

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Autores principales:	Nathou C, Etard O, Dollfus S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	electroconvulsive therapy repetitive transcranial magnetic stimulation transcranial direct current stimulation auditory hallucinations schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f39882205d8a4e80946f585396d83108
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spelling	oai:doaj.org-article:f39882205d8a4e80946f585396d831082021-12-02T05:50:57ZAuditory verbal hallucinations in schizophrenia: current perspectives in brain stimulation treatments1178-2021https://doaj.org/article/f39882205d8a4e80946f585396d831082019-07-01T00:00:00Zhttps://www.dovepress.com/auditory-verbal-hallucinations-in-schizophrenia-current-perspectives-i-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Clément Nathou,1,2 Olivier Etard,2,3 Sonia Dollfus1,21Normandie Univ, UNICAEN, CHU de Caen, Service de Psychiatrie Adulte, Caen, F-14000, France; 2Normandie Univ, UNICAEN, ISTS, EA 7466, GIP Cyceron, Caen 14000, France; 3Normandie Univ, UNICAEN, CHU de Caen, Service des Explorations Fonctionnelles du Système Nerveux, CHU de Caen, Caen, F-14000, FrancePurpose: This review reports the current perspectives of brain stimulation techniques in the treatment of auditory verbal hallucinations (AVH) in schizophrenia.Methods: A systematic search of the literature in the PubMed database revealed that the most studied techniques are noninvasive techniques (NIBS), including electroconvulsive therapy (ECT), transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS).Results: The results showed that ECT could have great clinical efficacy but is currently underused in practice perhaps due to the costs associated with its limited implementation and potential associated risks. tDCS is still poorly studied and does not demonstrate sufficiently homogeneous or conclusive results yet to prove its efficacy in the treatment of AVH. However, its safe and simple implementation allows us to recommend it to patients who are refractory to other stimulation techniques. Finally, rTMS seems to be the most efficacious NIBS to offer patients with persistent AVH as an add-on therapeutic strategy. Its implementation has a non negligible cost but can be performed by a single practitioner. Great evolution in these techniques with technological progress, robotics and computer science are currently being tested and will undoubtedly improve the clinical efficacy of these procedures, particularly towards more personalized treatments such as individual rTMS targets and intensities. There are also new techniques for deep brain stimulation based on focused ultrasound that could provide much insight into the treatment of AVH in schizophrenia.Conclusion: This review suggests that add-on brain stimulation treatments could play a key role among the therapeutic strategies for auditory hallucinations reduction in schizophrenia.Keywords: electroconvulsive therapy, repetitive transcranial magnetic stimulation, transcranial direct current stimulation, auditory hallucinations, schizophreniaNathou CEtard ODollfus SDove Medical Pressarticleelectroconvulsive therapyrepetitive transcranial magnetic stimulationtranscranial direct current stimulationauditory hallucinationsschizophreniaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2105-2117 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	electroconvulsive therapy repetitive transcranial magnetic stimulation transcranial direct current stimulation auditory hallucinations schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	electroconvulsive therapy repetitive transcranial magnetic stimulation transcranial direct current stimulation auditory hallucinations schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Nathou C Etard O Dollfus S Auditory verbal hallucinations in schizophrenia: current perspectives in brain stimulation treatments
description	Clément Nathou,1,2 Olivier Etard,2,3 Sonia Dollfus1,21Normandie Univ, UNICAEN, CHU de Caen, Service de Psychiatrie Adulte, Caen, F-14000, France; 2Normandie Univ, UNICAEN, ISTS, EA 7466, GIP Cyceron, Caen 14000, France; 3Normandie Univ, UNICAEN, CHU de Caen, Service des Explorations Fonctionnelles du Système Nerveux, CHU de Caen, Caen, F-14000, FrancePurpose: This review reports the current perspectives of brain stimulation techniques in the treatment of auditory verbal hallucinations (AVH) in schizophrenia.Methods: A systematic search of the literature in the PubMed database revealed that the most studied techniques are noninvasive techniques (NIBS), including electroconvulsive therapy (ECT), transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS).Results: The results showed that ECT could have great clinical efficacy but is currently underused in practice perhaps due to the costs associated with its limited implementation and potential associated risks. tDCS is still poorly studied and does not demonstrate sufficiently homogeneous or conclusive results yet to prove its efficacy in the treatment of AVH. However, its safe and simple implementation allows us to recommend it to patients who are refractory to other stimulation techniques. Finally, rTMS seems to be the most efficacious NIBS to offer patients with persistent AVH as an add-on therapeutic strategy. Its implementation has a non negligible cost but can be performed by a single practitioner. Great evolution in these techniques with technological progress, robotics and computer science are currently being tested and will undoubtedly improve the clinical efficacy of these procedures, particularly towards more personalized treatments such as individual rTMS targets and intensities. There are also new techniques for deep brain stimulation based on focused ultrasound that could provide much insight into the treatment of AVH in schizophrenia.Conclusion: This review suggests that add-on brain stimulation treatments could play a key role among the therapeutic strategies for auditory hallucinations reduction in schizophrenia.Keywords: electroconvulsive therapy, repetitive transcranial magnetic stimulation, transcranial direct current stimulation, auditory hallucinations, schizophrenia
format	article
author	Nathou C Etard O Dollfus S
author_facet	Nathou C Etard O Dollfus S
author_sort	Nathou C
title	Auditory verbal hallucinations in schizophrenia: current perspectives in brain stimulation treatments
title_short	Auditory verbal hallucinations in schizophrenia: current perspectives in brain stimulation treatments
title_full	Auditory verbal hallucinations in schizophrenia: current perspectives in brain stimulation treatments
title_fullStr	Auditory verbal hallucinations in schizophrenia: current perspectives in brain stimulation treatments
title_full_unstemmed	Auditory verbal hallucinations in schizophrenia: current perspectives in brain stimulation treatments
title_sort	auditory verbal hallucinations in schizophrenia: current perspectives in brain stimulation treatments
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/f39882205d8a4e80946f585396d83108
work_keys_str_mv	AT nathouc auditoryverbalhallucinationsinschizophreniacurrentperspectivesinbrainstimulationtreatments AT etardo auditoryverbalhallucinationsinschizophreniacurrentperspectivesinbrainstimulationtreatments AT dollfuss auditoryverbalhallucinationsinschizophreniacurrentperspectivesinbrainstimulationtreatments
_version_	1718400209212407808

Auditory verbal hallucinations in schizophrenia: current perspectives in brain stimulation treatments

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