Bidirectional introgressive hybridization between a cattle and human schistosome species.

Schistosomiasis is a disease of great medical and veterinary importance in tropical and subtropical regions, caused by parasitic flatworms of the genus Schistosoma (subclass Digenea). Following major water development schemes in the 1980s, schistosomiasis has become an important parasitic disease of...

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Autores principales:	Tine Huyse, Bonnie L Webster, Sarah Geldof, J Russell Stothard, Oumar T Diaw, Katja Polman, David Rollinson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f39ae6dda33e49e68fe3594c05f4bcf2
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spelling	oai:doaj.org-article:f39ae6dda33e49e68fe3594c05f4bcf22021-11-25T05:47:39ZBidirectional introgressive hybridization between a cattle and human schistosome species.1553-73661553-737410.1371/journal.ppat.1000571https://doaj.org/article/f39ae6dda33e49e68fe3594c05f4bcf22009-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19730700/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Schistosomiasis is a disease of great medical and veterinary importance in tropical and subtropical regions, caused by parasitic flatworms of the genus Schistosoma (subclass Digenea). Following major water development schemes in the 1980s, schistosomiasis has become an important parasitic disease of children living in the Senegal River Basin (SRB). During molecular parasitological surveys, nuclear and mitochondrial markers revealed unexpected natural interactions between a bovine and human Schistosoma species: S. bovis and S. haematobium, respectively. Hybrid schistosomes recovered from the urine and faeces of children and the intermediate snail hosts of both parental species, Bulinus truncatus and B. globosus, presented a nuclear ITS rRNA sequence identical to S. haematobium, while the partial mitochondrial cox1 sequence was identified as S. bovis. Molecular data suggest that the hybrids are not 1st generation and are a result of parental and/or hybrid backcrosses, indicating a stable hybrid zone. Larval stages with the reverse genetic profile were also found and are suggested to be F1 progeny. The data provide indisputable evidence for the occurrence of bidirectional introgressive hybridization between a bovine and a human Schistosoma species. Hybrid species have been found infecting B. truncatus, a snail species that is now very abundant throughout the SRB. The recent increase in urinary schistosomiasis in the villages along the SRB could therefore be a direct effect of the increased transmission through B. truncatus. Hybridization between schistosomes under laboratory conditions has been shown to result in heterosis (higher fecundity, faster maturation time, wider intermediate host spectrum), having important implications on disease prevalence, pathology and treatment. If this new hybrid exhibits the same hybrid vigour, it could develop into an emerging pathogen, necessitating further control strategies in zones where both parental species overlap.Tine HuyseBonnie L WebsterSarah GeldofJ Russell StothardOumar T DiawKatja PolmanDavid RollinsonPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 5, Iss 9, p e1000571 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Tine Huyse Bonnie L Webster Sarah Geldof J Russell Stothard Oumar T Diaw Katja Polman David Rollinson Bidirectional introgressive hybridization between a cattle and human schistosome species.
description	Schistosomiasis is a disease of great medical and veterinary importance in tropical and subtropical regions, caused by parasitic flatworms of the genus Schistosoma (subclass Digenea). Following major water development schemes in the 1980s, schistosomiasis has become an important parasitic disease of children living in the Senegal River Basin (SRB). During molecular parasitological surveys, nuclear and mitochondrial markers revealed unexpected natural interactions between a bovine and human Schistosoma species: S. bovis and S. haematobium, respectively. Hybrid schistosomes recovered from the urine and faeces of children and the intermediate snail hosts of both parental species, Bulinus truncatus and B. globosus, presented a nuclear ITS rRNA sequence identical to S. haematobium, while the partial mitochondrial cox1 sequence was identified as S. bovis. Molecular data suggest that the hybrids are not 1st generation and are a result of parental and/or hybrid backcrosses, indicating a stable hybrid zone. Larval stages with the reverse genetic profile were also found and are suggested to be F1 progeny. The data provide indisputable evidence for the occurrence of bidirectional introgressive hybridization between a bovine and a human Schistosoma species. Hybrid species have been found infecting B. truncatus, a snail species that is now very abundant throughout the SRB. The recent increase in urinary schistosomiasis in the villages along the SRB could therefore be a direct effect of the increased transmission through B. truncatus. Hybridization between schistosomes under laboratory conditions has been shown to result in heterosis (higher fecundity, faster maturation time, wider intermediate host spectrum), having important implications on disease prevalence, pathology and treatment. If this new hybrid exhibits the same hybrid vigour, it could develop into an emerging pathogen, necessitating further control strategies in zones where both parental species overlap.
format	article
author	Tine Huyse Bonnie L Webster Sarah Geldof J Russell Stothard Oumar T Diaw Katja Polman David Rollinson
author_facet	Tine Huyse Bonnie L Webster Sarah Geldof J Russell Stothard Oumar T Diaw Katja Polman David Rollinson
author_sort	Tine Huyse
title	Bidirectional introgressive hybridization between a cattle and human schistosome species.
title_short	Bidirectional introgressive hybridization between a cattle and human schistosome species.
title_full	Bidirectional introgressive hybridization between a cattle and human schistosome species.
title_fullStr	Bidirectional introgressive hybridization between a cattle and human schistosome species.
title_full_unstemmed	Bidirectional introgressive hybridization between a cattle and human schistosome species.
title_sort	bidirectional introgressive hybridization between a cattle and human schistosome species.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/f39ae6dda33e49e68fe3594c05f4bcf2
work_keys_str_mv	AT tinehuyse bidirectionalintrogressivehybridizationbetweenacattleandhumanschistosomespecies AT bonnielwebster bidirectionalintrogressivehybridizationbetweenacattleandhumanschistosomespecies AT sarahgeldof bidirectionalintrogressivehybridizationbetweenacattleandhumanschistosomespecies AT jrussellstothard bidirectionalintrogressivehybridizationbetweenacattleandhumanschistosomespecies AT oumartdiaw bidirectionalintrogressivehybridizationbetweenacattleandhumanschistosomespecies AT katjapolman bidirectionalintrogressivehybridizationbetweenacattleandhumanschistosomespecies AT davidrollinson bidirectionalintrogressivehybridizationbetweenacattleandhumanschistosomespecies
_version_	1718414494488592384

Bidirectional introgressive hybridization between a cattle and human schistosome species.

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