Elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits

Abstract Background Despite inconsistent findings, accumulative evidence has shown abnormalities of the key antioxidant enzyme, superoxide dismutase (SOD), in patients with schizophrenia. However, few studies explored SOD in late-life schizophrenia (LLS). Our work aimed to investigate changes in SOD...

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Autores principales:	Lijuan Huo, Xiaobing Lu, Fengchun Wu, Catherine Chang, Yuping Ning, Xiang Yang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Geriatric schizophrenia Oxidative stress Plasma Cognition Negative symptoms Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/f39b38a2199c41218b67b24944a6e6c2
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spelling	oai:doaj.org-article:f39b38a2199c41218b67b24944a6e6c22021-12-05T12:06:03ZElevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits10.1186/s12888-021-03604-51471-244Xhttps://doaj.org/article/f39b38a2199c41218b67b24944a6e6c22021-12-01T00:00:00Zhttps://doi.org/10.1186/s12888-021-03604-5https://doaj.org/toc/1471-244XAbstract Background Despite inconsistent findings, accumulative evidence has shown abnormalities of the key antioxidant enzyme, superoxide dismutase (SOD), in patients with schizophrenia. However, few studies explored SOD in late-life schizophrenia (LLS). Our work aimed to investigate changes in SOD activity and the relationship between SOD activity and psychotic symptoms or cognitive deficits in LLS. Methods 32 geriatric male patients with schizophrenia (age ≥ 60) and 28 age-matched male normal controls were recruited in the study. We assessed cognitive functions with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), evaluated the severity of clinical symptoms with the Positive and Negative Syndrome Scale (PANSS), and measured the plasma levels of SOD. Results Patients with LLS presented with higher total levels of SOD compared to the controls (81.70 vs. 65.26 U/ml, p < .001). Except for the visuospatial index, the cognitive performance was significantly worse on RBANS total and other domain scores in the schizophrenia group than the control group. In the schizophrenia group, SOD levels were positively correlated with subscores of general psychopathology and negative symptoms and total scores of the PANSS (all p < .05), and inversely associated with performance in immediate memory, language, and RBANS total scores (all p < .05). Conclusions Our findings suggest that patients with LLS display disturbances in the antioxidant system, which may underlie the pathological process of cognitive impairments and negative symptoms in the late stage of schizophrenia. Supplementing with antioxidants could be a potential treatment.Lijuan HuoXiaobing LuFengchun WuCatherine ChangYuping NingXiang Yang ZhangBMCarticleGeriatric schizophreniaOxidative stressPlasmaCognitionNegative symptomsPsychiatryRC435-571ENBMC Psychiatry, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatric schizophrenia Oxidative stress Plasma Cognition Negative symptoms Psychiatry RC435-571
spellingShingle	Geriatric schizophrenia Oxidative stress Plasma Cognition Negative symptoms Psychiatry RC435-571 Lijuan Huo Xiaobing Lu Fengchun Wu Catherine Chang Yuping Ning Xiang Yang Zhang Elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits
description	Abstract Background Despite inconsistent findings, accumulative evidence has shown abnormalities of the key antioxidant enzyme, superoxide dismutase (SOD), in patients with schizophrenia. However, few studies explored SOD in late-life schizophrenia (LLS). Our work aimed to investigate changes in SOD activity and the relationship between SOD activity and psychotic symptoms or cognitive deficits in LLS. Methods 32 geriatric male patients with schizophrenia (age ≥ 60) and 28 age-matched male normal controls were recruited in the study. We assessed cognitive functions with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), evaluated the severity of clinical symptoms with the Positive and Negative Syndrome Scale (PANSS), and measured the plasma levels of SOD. Results Patients with LLS presented with higher total levels of SOD compared to the controls (81.70 vs. 65.26 U/ml, p < .001). Except for the visuospatial index, the cognitive performance was significantly worse on RBANS total and other domain scores in the schizophrenia group than the control group. In the schizophrenia group, SOD levels were positively correlated with subscores of general psychopathology and negative symptoms and total scores of the PANSS (all p < .05), and inversely associated with performance in immediate memory, language, and RBANS total scores (all p < .05). Conclusions Our findings suggest that patients with LLS display disturbances in the antioxidant system, which may underlie the pathological process of cognitive impairments and negative symptoms in the late stage of schizophrenia. Supplementing with antioxidants could be a potential treatment.
format	article
author	Lijuan Huo Xiaobing Lu Fengchun Wu Catherine Chang Yuping Ning Xiang Yang Zhang
author_facet	Lijuan Huo Xiaobing Lu Fengchun Wu Catherine Chang Yuping Ning Xiang Yang Zhang
author_sort	Lijuan Huo
title	Elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits
title_short	Elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits
title_full	Elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits
title_fullStr	Elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits
title_full_unstemmed	Elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits
title_sort	elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f39b38a2199c41218b67b24944a6e6c2
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Elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits

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