Saccharomyces boulardii modulates oxidative stress and renin angiotensin system attenuating diabetes-induced liver injury in mice

Abstract Type 1 diabetes (T1DM) is a chronic disease characterized by hyperglycemia due to a deficiency in endogenous insulin production, resulting from pancreatic beta cell death. Persistent hyperglycemia leads to enhanced oxidative stress and liver injury. Several studies have evaluated the anti-d...

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Autores principales:	Leticia Barssotti, Isabel C. M. E. Abreu, Ana Beatriz P. Brandão, Raquel C. M. F. Albuquerque, Fabiana G. Ferreira, Miguel A. C. Salgado, Danielle D. S. Dias, Kátia De Angelis, Rodrigo Yokota, Dulce E. Casarini, Lívia B. Souza, Carla R. Taddei, Tatiana S. Cunha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f39bc0da65604549b5e66622ef9aa72b
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spelling	oai:doaj.org-article:f39bc0da65604549b5e66622ef9aa72b2021-12-02T13:41:43ZSaccharomyces boulardii modulates oxidative stress and renin angiotensin system attenuating diabetes-induced liver injury in mice10.1038/s41598-021-88497-w2045-2322https://doaj.org/article/f39bc0da65604549b5e66622ef9aa72b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88497-whttps://doaj.org/toc/2045-2322Abstract Type 1 diabetes (T1DM) is a chronic disease characterized by hyperglycemia due to a deficiency in endogenous insulin production, resulting from pancreatic beta cell death. Persistent hyperglycemia leads to enhanced oxidative stress and liver injury. Several studies have evaluated the anti-diabetic and protective effects of probiotic strains in animal models. In the present study, we investigated, through histopathological and biochemical analyses, the effects of eight weeks of administration of Saccharomyces boulardii (S. boulardii) yeast on the liver of streptozotocin (STZ) induced diabetic C57BL/6 mice. Our results demonstrated that S. boulardii attenuates hepatocytes hydropic degeneration and hepatic vessels congestion in STZ-induced diabetic mice. The treatment attenuated the oxidative stress in diabetic mice leading to a reduction of carbonylated protein concentration and increased activity of antioxidant enzymes superoxide dismutase and glutathione peroxidase, compared to untreated diabetic animals. The results also show the beneficial influence of S. boulardii in regulating the hepatic concentration of renin angiotensin system (RAS) peptides. Therefore, our results demonstrated that S. boulardii administration to STZ-induced diabetic mice reduces oxidative stress and normalizes the concentration of RAS peptides, supporting the hypothesis that this yeast may have a role as a potential adjunctive therapy to attenuate diabetes-induced liver injury.Leticia BarssottiIsabel C. M. E. AbreuAna Beatriz P. BrandãoRaquel C. M. F. AlbuquerqueFabiana G. FerreiraMiguel A. C. SalgadoDanielle D. S. DiasKátia De AngelisRodrigo YokotaDulce E. CasariniLívia B. SouzaCarla R. TaddeiTatiana S. CunhaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leticia Barssotti Isabel C. M. E. Abreu Ana Beatriz P. Brandão Raquel C. M. F. Albuquerque Fabiana G. Ferreira Miguel A. C. Salgado Danielle D. S. Dias Kátia De Angelis Rodrigo Yokota Dulce E. Casarini Lívia B. Souza Carla R. Taddei Tatiana S. Cunha Saccharomyces boulardii modulates oxidative stress and renin angiotensin system attenuating diabetes-induced liver injury in mice
description	Abstract Type 1 diabetes (T1DM) is a chronic disease characterized by hyperglycemia due to a deficiency in endogenous insulin production, resulting from pancreatic beta cell death. Persistent hyperglycemia leads to enhanced oxidative stress and liver injury. Several studies have evaluated the anti-diabetic and protective effects of probiotic strains in animal models. In the present study, we investigated, through histopathological and biochemical analyses, the effects of eight weeks of administration of Saccharomyces boulardii (S. boulardii) yeast on the liver of streptozotocin (STZ) induced diabetic C57BL/6 mice. Our results demonstrated that S. boulardii attenuates hepatocytes hydropic degeneration and hepatic vessels congestion in STZ-induced diabetic mice. The treatment attenuated the oxidative stress in diabetic mice leading to a reduction of carbonylated protein concentration and increased activity of antioxidant enzymes superoxide dismutase and glutathione peroxidase, compared to untreated diabetic animals. The results also show the beneficial influence of S. boulardii in regulating the hepatic concentration of renin angiotensin system (RAS) peptides. Therefore, our results demonstrated that S. boulardii administration to STZ-induced diabetic mice reduces oxidative stress and normalizes the concentration of RAS peptides, supporting the hypothesis that this yeast may have a role as a potential adjunctive therapy to attenuate diabetes-induced liver injury.
format	article
author	Leticia Barssotti Isabel C. M. E. Abreu Ana Beatriz P. Brandão Raquel C. M. F. Albuquerque Fabiana G. Ferreira Miguel A. C. Salgado Danielle D. S. Dias Kátia De Angelis Rodrigo Yokota Dulce E. Casarini Lívia B. Souza Carla R. Taddei Tatiana S. Cunha
author_facet	Leticia Barssotti Isabel C. M. E. Abreu Ana Beatriz P. Brandão Raquel C. M. F. Albuquerque Fabiana G. Ferreira Miguel A. C. Salgado Danielle D. S. Dias Kátia De Angelis Rodrigo Yokota Dulce E. Casarini Lívia B. Souza Carla R. Taddei Tatiana S. Cunha
author_sort	Leticia Barssotti
title	Saccharomyces boulardii modulates oxidative stress and renin angiotensin system attenuating diabetes-induced liver injury in mice
title_short	Saccharomyces boulardii modulates oxidative stress and renin angiotensin system attenuating diabetes-induced liver injury in mice
title_full	Saccharomyces boulardii modulates oxidative stress and renin angiotensin system attenuating diabetes-induced liver injury in mice
title_fullStr	Saccharomyces boulardii modulates oxidative stress and renin angiotensin system attenuating diabetes-induced liver injury in mice
title_full_unstemmed	Saccharomyces boulardii modulates oxidative stress and renin angiotensin system attenuating diabetes-induced liver injury in mice
title_sort	saccharomyces boulardii modulates oxidative stress and renin angiotensin system attenuating diabetes-induced liver injury in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f39bc0da65604549b5e66622ef9aa72b
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Saccharomyces boulardii modulates oxidative stress and renin angiotensin system attenuating diabetes-induced liver injury in mice

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