Therapeutic vaccine BRII-179 restores HBV-specific immune responses in patients with chronic HBV in a phase Ib/IIa study

Background & Aims: Functional cure of chronic HBV infection (CHB) without life-long treatment requires the restoration of defective HBV-specific humoral and cellular immunity. Therapeutic vaccines based on the major structural and non-structural proteins have been tested in patients with CHB...

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Autores principales:	Haiyan Ma, Tien Huey Lim, Apinya Leerapun, Martin Weltman, Jidong Jia, Young-suk Lim, Pisit Tangkijvanich, Wattana Sukeepaisarnjaroen, Yun Ji, Nina Le Bert, Dong Li, Yao Zhang, Robert Hamatake, Nicole Tan, Chunming Li, Simone I. Strasser, Huiguo Ding, Jung-Hwan Yoon, Nigel H. Stace, Tanvir Ahmed, Dave E. Anderson, Li Yan, Antonio Bertoletti, Qing Zhu, Man-Fung Yuen
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	CHB BRII-179 immunotherapy IFN-alpha HBV-specific immune response Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/f39d5e3a799b485ca22dc42380e0af66
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Therapeutic vaccine BRII-179 restores HBV-specific immune responses in patients with chronic HBV in a phase Ib/IIa study

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