Therapeutic vaccine BRII-179 restores HBV-specific immune responses in patients with chronic HBV in a phase Ib/IIa study

Therapeutic vaccine BRII-179 restores HBV-specific immune responses in patients with chronic HBV in a phase Ib/IIa study

Background & Aims: Functional cure of chronic HBV infection (CHB) without life-long treatment requires the restoration of defective HBV-specific humoral and cellular immunity. Therapeutic vaccines based on the major structural and non-structural proteins have been tested in patients with CHB...

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Main Authors: Haiyan Ma, Tien Huey Lim, Apinya Leerapun, Martin Weltman, Jidong Jia, Young-suk Lim, Pisit Tangkijvanich, Wattana Sukeepaisarnjaroen, Yun Ji, Nina Le Bert, Dong Li, Yao Zhang, Robert Hamatake, Nicole Tan, Chunming Li, Simone I. Strasser, Huiguo Ding, Jung-Hwan Yoon, Nigel H. Stace, Tanvir Ahmed, Dave E. Anderson, Li Yan, Antonio Bertoletti, Qing Zhu, Man-Fung Yuen
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
CHB
BRII-179
immunotherapy
IFN-alpha
HBV-specific immune response
Diseases of the digestive system. Gastroenterology
RC799-869
Online Access:https://doaj.org/article/f39d5e3a799b485ca22dc42380e0af66
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https://doaj.org/article/f39d5e3a799b485ca22dc42380e0af66

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