Potential role of M2 TAMs around lymphatic vessels during lymphatic invasion in papillary thyroid carcinoma

Abstract The aim of this study was to examine whether lymphatic invasion in papillary thyroid carcinoma (PTC) occurs when tumour-associated macrophages (TAMs) injure lymphatic vessels together with cancer cells. While there was no difference in the lymphatic vessel density in PTC and follicular thyr...

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Autores principales:	Takanobu Kabasawa, Rintaro Ohe, Naing Ye Aung, Yuka Urano, Takumi Kitaoka, Nobuyuki Tamazawa, Aya Utsunomiya, Mitsunori Yamakawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f39dc127a746419c8cd90fdadf6f3604
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spelling	oai:doaj.org-article:f39dc127a746419c8cd90fdadf6f36042021-12-02T14:01:24ZPotential role of M2 TAMs around lymphatic vessels during lymphatic invasion in papillary thyroid carcinoma10.1038/s41598-020-80694-32045-2322https://doaj.org/article/f39dc127a746419c8cd90fdadf6f36042021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80694-3https://doaj.org/toc/2045-2322Abstract The aim of this study was to examine whether lymphatic invasion in papillary thyroid carcinoma (PTC) occurs when tumour-associated macrophages (TAMs) injure lymphatic vessels together with cancer cells. While there was no difference in the lymphatic vessel density in PTC and follicular thyroid carcinoma (FTC), the number of TAMs around the lymphatic vessels was increased in PTC compared to that in FTC. In particular, TAMs were observed together with cancer cells in lymphatic invasive lesions, and the number of M2 cells inside and outside the lymphatic vessels showed a significant correlation. MMP-2 mRNA was expressed in nonneoplastic stromal cells as well as cancer cells, and double immunofluorescence staining confirmed M2 positivity. Consequently, this study reveals that M2 TAMs around lymphatic vessels within the tumour border of PTC may be associated with the lymphatic invasion of cancer cells. This study represents a step forward in elucidating the mechanism of lymphatic invasion.Takanobu KabasawaRintaro OheNaing Ye AungYuka UranoTakumi KitaokaNobuyuki TamazawaAya UtsunomiyaMitsunori YamakawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takanobu Kabasawa Rintaro Ohe Naing Ye Aung Yuka Urano Takumi Kitaoka Nobuyuki Tamazawa Aya Utsunomiya Mitsunori Yamakawa Potential role of M2 TAMs around lymphatic vessels during lymphatic invasion in papillary thyroid carcinoma
description	Abstract The aim of this study was to examine whether lymphatic invasion in papillary thyroid carcinoma (PTC) occurs when tumour-associated macrophages (TAMs) injure lymphatic vessels together with cancer cells. While there was no difference in the lymphatic vessel density in PTC and follicular thyroid carcinoma (FTC), the number of TAMs around the lymphatic vessels was increased in PTC compared to that in FTC. In particular, TAMs were observed together with cancer cells in lymphatic invasive lesions, and the number of M2 cells inside and outside the lymphatic vessels showed a significant correlation. MMP-2 mRNA was expressed in nonneoplastic stromal cells as well as cancer cells, and double immunofluorescence staining confirmed M2 positivity. Consequently, this study reveals that M2 TAMs around lymphatic vessels within the tumour border of PTC may be associated with the lymphatic invasion of cancer cells. This study represents a step forward in elucidating the mechanism of lymphatic invasion.
format	article
author	Takanobu Kabasawa Rintaro Ohe Naing Ye Aung Yuka Urano Takumi Kitaoka Nobuyuki Tamazawa Aya Utsunomiya Mitsunori Yamakawa
author_facet	Takanobu Kabasawa Rintaro Ohe Naing Ye Aung Yuka Urano Takumi Kitaoka Nobuyuki Tamazawa Aya Utsunomiya Mitsunori Yamakawa
author_sort	Takanobu Kabasawa
title	Potential role of M2 TAMs around lymphatic vessels during lymphatic invasion in papillary thyroid carcinoma
title_short	Potential role of M2 TAMs around lymphatic vessels during lymphatic invasion in papillary thyroid carcinoma
title_full	Potential role of M2 TAMs around lymphatic vessels during lymphatic invasion in papillary thyroid carcinoma
title_fullStr	Potential role of M2 TAMs around lymphatic vessels during lymphatic invasion in papillary thyroid carcinoma
title_full_unstemmed	Potential role of M2 TAMs around lymphatic vessels during lymphatic invasion in papillary thyroid carcinoma
title_sort	potential role of m2 tams around lymphatic vessels during lymphatic invasion in papillary thyroid carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f39dc127a746419c8cd90fdadf6f3604
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Potential role of M2 TAMs around lymphatic vessels during lymphatic invasion in papillary thyroid carcinoma

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