Responsiveness to ripasudil may be a potential outcome marker for selective laser trabeculoplasty in patients with primary open-angle glaucoma

Abstract We examined responsiveness to ripasudil as a potential factor for predicting the effect of selective laser trabeculoplasty (SLT) when performed for primary open-angle glaucoma (POAG). A total of 70 eyes with no history of glaucoma surgery underwent SLT between January 2015 and June 2019. Pa...

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Autores principales:	Taro Baba, Kazuyuki Hirooka, Hiroki Nii, Yoshiaki Kiuchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f39f838d49e24625a550fb868120912c
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spelling	oai:doaj.org-article:f39f838d49e24625a550fb868120912c2021-12-02T15:52:21ZResponsiveness to ripasudil may be a potential outcome marker for selective laser trabeculoplasty in patients with primary open-angle glaucoma10.1038/s41598-021-85271-w2045-2322https://doaj.org/article/f39f838d49e24625a550fb868120912c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85271-whttps://doaj.org/toc/2045-2322Abstract We examined responsiveness to ripasudil as a potential factor for predicting the effect of selective laser trabeculoplasty (SLT) when performed for primary open-angle glaucoma (POAG). A total of 70 eyes with no history of glaucoma surgery underwent SLT between January 2015 and June 2019. Patients were divided into two groups, with an intraocular pressure (IOP) decrease of 15% or more due to ripasudil administration before SLT defined as the effective group, while an IOP decrease of less than 15% was defined as the non-effective group. Kaplan–Meier survival analysis was performed. A Cox proportional hazards model assessed the influence of baseline factors on the success. Of the 70 eyes evaluated, treatments were effective in 22 and non-effective in 48. Postoperatively, both groups exhibited IOP reductions for up to 24 months. Success ratios at 12 and 24 months after SLT were 43.5% and 18.5% in the effective versus 24.9% and 9.3% in the non-effective group, which were significantly higher in the effective group (P = 0.03). Presence of a ripasudil effective eye (P = 0.03) was associated with treatment success. Responsiveness to ripasudil may be useful in predicting the therapeutic effect of SLT.Taro BabaKazuyuki HirookaHiroki NiiYoshiaki KiuchiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Taro Baba Kazuyuki Hirooka Hiroki Nii Yoshiaki Kiuchi Responsiveness to ripasudil may be a potential outcome marker for selective laser trabeculoplasty in patients with primary open-angle glaucoma
description	Abstract We examined responsiveness to ripasudil as a potential factor for predicting the effect of selective laser trabeculoplasty (SLT) when performed for primary open-angle glaucoma (POAG). A total of 70 eyes with no history of glaucoma surgery underwent SLT between January 2015 and June 2019. Patients were divided into two groups, with an intraocular pressure (IOP) decrease of 15% or more due to ripasudil administration before SLT defined as the effective group, while an IOP decrease of less than 15% was defined as the non-effective group. Kaplan–Meier survival analysis was performed. A Cox proportional hazards model assessed the influence of baseline factors on the success. Of the 70 eyes evaluated, treatments were effective in 22 and non-effective in 48. Postoperatively, both groups exhibited IOP reductions for up to 24 months. Success ratios at 12 and 24 months after SLT were 43.5% and 18.5% in the effective versus 24.9% and 9.3% in the non-effective group, which were significantly higher in the effective group (P = 0.03). Presence of a ripasudil effective eye (P = 0.03) was associated with treatment success. Responsiveness to ripasudil may be useful in predicting the therapeutic effect of SLT.
format	article
author	Taro Baba Kazuyuki Hirooka Hiroki Nii Yoshiaki Kiuchi
author_facet	Taro Baba Kazuyuki Hirooka Hiroki Nii Yoshiaki Kiuchi
author_sort	Taro Baba
title	Responsiveness to ripasudil may be a potential outcome marker for selective laser trabeculoplasty in patients with primary open-angle glaucoma
title_short	Responsiveness to ripasudil may be a potential outcome marker for selective laser trabeculoplasty in patients with primary open-angle glaucoma
title_full	Responsiveness to ripasudil may be a potential outcome marker for selective laser trabeculoplasty in patients with primary open-angle glaucoma
title_fullStr	Responsiveness to ripasudil may be a potential outcome marker for selective laser trabeculoplasty in patients with primary open-angle glaucoma
title_full_unstemmed	Responsiveness to ripasudil may be a potential outcome marker for selective laser trabeculoplasty in patients with primary open-angle glaucoma
title_sort	responsiveness to ripasudil may be a potential outcome marker for selective laser trabeculoplasty in patients with primary open-angle glaucoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f39f838d49e24625a550fb868120912c
work_keys_str_mv	AT tarobaba responsivenesstoripasudilmaybeapotentialoutcomemarkerforselectivelasertrabeculoplastyinpatientswithprimaryopenangleglaucoma AT kazuyukihirooka responsivenesstoripasudilmaybeapotentialoutcomemarkerforselectivelasertrabeculoplastyinpatientswithprimaryopenangleglaucoma AT hirokinii responsivenesstoripasudilmaybeapotentialoutcomemarkerforselectivelasertrabeculoplastyinpatientswithprimaryopenangleglaucoma AT yoshiakikiuchi responsivenesstoripasudilmaybeapotentialoutcomemarkerforselectivelasertrabeculoplastyinpatientswithprimaryopenangleglaucoma
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Responsiveness to ripasudil may be a potential outcome marker for selective laser trabeculoplasty in patients with primary open-angle glaucoma

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