Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4

Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4

Nontyphoidal Salmonella (NTS) is a major cause of bacteraemia in children and HIV-infected adults in Africa. Here, Gilchrist et al. conduct a genome-wide association study and show that genetic variation in STAT4 is a determinant of NTS in Kenyan and Malawian children.

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Detalles Bibliográficos
Autores principales: James J. Gilchrist, Anna Rautanen, Benjamin P. Fairfax, Tara C. Mills, Vivek Naranbhai, Holly Trochet, Matti Pirinen, Esther Muthumbi, Salim Mwarumba, Patricia Njuguna, Neema Mturi, Chisomo L. Msefula, Esther N. Gondwe, Jenny M. MacLennan, Stephen J. Chapman, Malcolm E. Molyneux, Julian C. Knight, Chris C. A. Spencer, Thomas N. Williams, Calman A. MacLennan, J. Anthony G. Scott, Adrian V. S. Hill
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/f39fdec2fbbb4ab0bac55463ac8b21f7
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Sumario:Nontyphoidal Salmonella (NTS) is a major cause of bacteraemia in children and HIV-infected adults in Africa. Here, Gilchrist et al. conduct a genome-wide association study and show that genetic variation in STAT4 is a determinant of NTS in Kenyan and Malawian children.

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