Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α

Synaptic organizers are cell-adhesion molecules capable of inducing synaptic differentiation through transsynaptic interactions. Here the authors present the crystal structure of the intracellular interaction between the synaptic organizer PTPδ and Liprin-α to reveal the structural mechanism of intr...

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Autores principales:	Maiko Wakita, Atsushi Yamagata, Tomoko Shiroshima, Hironori Izumi, Asami Maeda, Mizuki Sendo, Ayako Imai, Keiko Kubota, Sakurako Goto-Ito, Yusuke Sato, Hisashi Mori, Tomoyuki Yoshida, Shuya Fukai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f3a3b04487b0410792c518a75d28e75e
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spelling	oai:doaj.org-article:f3a3b04487b0410792c518a75d28e75e2021-12-02T14:40:30ZStructural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α10.1038/s41467-020-14516-52041-1723https://doaj.org/article/f3a3b04487b0410792c518a75d28e75e2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14516-5https://doaj.org/toc/2041-1723Synaptic organizers are cell-adhesion molecules capable of inducing synaptic differentiation through transsynaptic interactions. Here the authors present the crystal structure of the intracellular interaction between the synaptic organizer PTPδ and Liprin-α to reveal the structural mechanism of intracellular molecular interactions for IIa-RPTP-mediated synapse formation.Maiko WakitaAtsushi YamagataTomoko ShiroshimaHironori IzumiAsami MaedaMizuki SendoAyako ImaiKeiko KubotaSakurako Goto-ItoYusuke SatoHisashi MoriTomoyuki YoshidaShuya FukaiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maiko Wakita Atsushi Yamagata Tomoko Shiroshima Hironori Izumi Asami Maeda Mizuki Sendo Ayako Imai Keiko Kubota Sakurako Goto-Ito Yusuke Sato Hisashi Mori Tomoyuki Yoshida Shuya Fukai Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α
description	Synaptic organizers are cell-adhesion molecules capable of inducing synaptic differentiation through transsynaptic interactions. Here the authors present the crystal structure of the intracellular interaction between the synaptic organizer PTPδ and Liprin-α to reveal the structural mechanism of intracellular molecular interactions for IIa-RPTP-mediated synapse formation.
format	article
author	Maiko Wakita Atsushi Yamagata Tomoko Shiroshima Hironori Izumi Asami Maeda Mizuki Sendo Ayako Imai Keiko Kubota Sakurako Goto-Ito Yusuke Sato Hisashi Mori Tomoyuki Yoshida Shuya Fukai
author_facet	Maiko Wakita Atsushi Yamagata Tomoko Shiroshima Hironori Izumi Asami Maeda Mizuki Sendo Ayako Imai Keiko Kubota Sakurako Goto-Ito Yusuke Sato Hisashi Mori Tomoyuki Yoshida Shuya Fukai
author_sort	Maiko Wakita
title	Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α
title_short	Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α
title_full	Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α
title_fullStr	Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α
title_full_unstemmed	Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α
title_sort	structural insights into selective interaction between type iia receptor protein tyrosine phosphatases and liprin-α
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f3a3b04487b0410792c518a75d28e75e
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Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α

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