Impact of parasitic infection with Ascaris lumbricoides on pulmonary function tests in asthmatic and non-asthmatic children

Background: There is strong evidence for a causal relationship between helminthes infection and allergic disease like asthma due to the similarity in the way they respond. This study aimed to investigate the effects of Ascaris infection on pulmonary function tests (PFTs) to reveal the relationship b...

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Autores principales:	Suha Haithem Mohammed, Azza Sajid Jabbr, Nawal Khalil Ibrahim
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Ascaris lumbriocoides Asthma Pulmonary function tests Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/f3a66a5cf3ad416b9cd5632687af0dd1
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spelling	oai:doaj.org-article:f3a66a5cf3ad416b9cd5632687af0dd12021-11-12T04:32:45ZImpact of parasitic infection with Ascaris lumbricoides on pulmonary function tests in asthmatic and non-asthmatic children2213-007110.1016/j.rmcr.2021.101552https://doaj.org/article/f3a66a5cf3ad416b9cd5632687af0dd12021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213007121002148https://doaj.org/toc/2213-0071Background: There is strong evidence for a causal relationship between helminthes infection and allergic disease like asthma due to the similarity in the way they respond. This study aimed to investigate the effects of Ascaris infection on pulmonary function tests (PFTs) to reveal the relationship between ascariasis and asthma in children. Patients and methods: This a randomized-control study conducted in Basrah City, Iraq, in which four groups of a total of 490 children were enrolled: Group1 included 120 normal children; Group 2 included 135 asthmatic children; Group 3 who were 150 Ascaris infected children and group G4 included 85 asthmatic and Ascaris infected. PFTs, IgE level, differential blood count and parasitic examination were done for all groups. Results: Both group2 and 4, which included asthmatic children showed a significant decrease in PFT (P > 0.05),while the PFT of parasitic infected group was not affected. There were no significant changes in WBC, eosinophils and IgE between asthmatic and parasitic infected groups. Conclusion: Ascaris infection could induce the inflammatory immune response in children, but couldn't cause a significant effect on pulmonary function tests in these children; The impairment in PFT was due to asthma disease and not correlated to ascariasis.Suha Haithem MohammedAzza Sajid JabbrNawal Khalil IbrahimElsevierarticleAscaris lumbriocoidesAsthmaPulmonary function testsDiseases of the respiratory systemRC705-779ENRespiratory Medicine Case Reports, Vol 34, Iss , Pp 101552- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ascaris lumbriocoides Asthma Pulmonary function tests Diseases of the respiratory system RC705-779
spellingShingle	Ascaris lumbriocoides Asthma Pulmonary function tests Diseases of the respiratory system RC705-779 Suha Haithem Mohammed Azza Sajid Jabbr Nawal Khalil Ibrahim Impact of parasitic infection with Ascaris lumbricoides on pulmonary function tests in asthmatic and non-asthmatic children
description	Background: There is strong evidence for a causal relationship between helminthes infection and allergic disease like asthma due to the similarity in the way they respond. This study aimed to investigate the effects of Ascaris infection on pulmonary function tests (PFTs) to reveal the relationship between ascariasis and asthma in children. Patients and methods: This a randomized-control study conducted in Basrah City, Iraq, in which four groups of a total of 490 children were enrolled: Group1 included 120 normal children; Group 2 included 135 asthmatic children; Group 3 who were 150 Ascaris infected children and group G4 included 85 asthmatic and Ascaris infected. PFTs, IgE level, differential blood count and parasitic examination were done for all groups. Results: Both group2 and 4, which included asthmatic children showed a significant decrease in PFT (P > 0.05),while the PFT of parasitic infected group was not affected. There were no significant changes in WBC, eosinophils and IgE between asthmatic and parasitic infected groups. Conclusion: Ascaris infection could induce the inflammatory immune response in children, but couldn't cause a significant effect on pulmonary function tests in these children; The impairment in PFT was due to asthma disease and not correlated to ascariasis.
format	article
author	Suha Haithem Mohammed Azza Sajid Jabbr Nawal Khalil Ibrahim
author_facet	Suha Haithem Mohammed Azza Sajid Jabbr Nawal Khalil Ibrahim
author_sort	Suha Haithem Mohammed
title	Impact of parasitic infection with Ascaris lumbricoides on pulmonary function tests in asthmatic and non-asthmatic children
title_short	Impact of parasitic infection with Ascaris lumbricoides on pulmonary function tests in asthmatic and non-asthmatic children
title_full	Impact of parasitic infection with Ascaris lumbricoides on pulmonary function tests in asthmatic and non-asthmatic children
title_fullStr	Impact of parasitic infection with Ascaris lumbricoides on pulmonary function tests in asthmatic and non-asthmatic children
title_full_unstemmed	Impact of parasitic infection with Ascaris lumbricoides on pulmonary function tests in asthmatic and non-asthmatic children
title_sort	impact of parasitic infection with ascaris lumbricoides on pulmonary function tests in asthmatic and non-asthmatic children
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f3a66a5cf3ad416b9cd5632687af0dd1
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Impact of parasitic infection with Ascaris lumbricoides on pulmonary function tests in asthmatic and non-asthmatic children

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