TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells

Antiviral immune responses involve clustering of plasmacytoid dendritic cells (pDC) in response to endosomal TLR7-mediated sensing of viral RNA. Here the authors show the GTPase Arl8b controls translocation of TLR7+ endosomes to the periphery of the cell via microtubule interactions, thus enabling p...

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Autores principales:	Shin-Ichiroh Saitoh, Fumiko Abe, Atsuo Kanno, Natsuko Tanimura, Yoshiko Mori Saitoh, Ryutaro Fukui, Takuma Shibata, Katsuaki Sato, Takeshi Ichinohe, Mayumi Hayashi, Kazuishi Kubota, Hiroko Kozuka-Hata, Masaaki Oyama, Yorifumi Kikko, Toshiaki Katada, Kenji Kontani, Kensuke Miyake
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f3a96501c2b548c493e42bf4711580c2
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spelling	oai:doaj.org-article:f3a96501c2b548c493e42bf4711580c22021-12-02T17:06:08ZTLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells10.1038/s41467-017-01687-x2041-1723https://doaj.org/article/f3a96501c2b548c493e42bf4711580c22017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01687-xhttps://doaj.org/toc/2041-1723Antiviral immune responses involve clustering of plasmacytoid dendritic cells (pDC) in response to endosomal TLR7-mediated sensing of viral RNA. Here the authors show the GTPase Arl8b controls translocation of TLR7+ endosomes to the periphery of the cell via microtubule interactions, thus enabling pDC clustering and type I interferon production.Shin-Ichiroh SaitohFumiko AbeAtsuo KannoNatsuko TanimuraYoshiko Mori SaitohRyutaro FukuiTakuma ShibataKatsuaki SatoTakeshi IchinoheMayumi HayashiKazuishi KubotaHiroko Kozuka-HataMasaaki OyamaYorifumi KikkoToshiaki KatadaKenji KontaniKensuke MiyakeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shin-Ichiroh Saitoh Fumiko Abe Atsuo Kanno Natsuko Tanimura Yoshiko Mori Saitoh Ryutaro Fukui Takuma Shibata Katsuaki Sato Takeshi Ichinohe Mayumi Hayashi Kazuishi Kubota Hiroko Kozuka-Hata Masaaki Oyama Yorifumi Kikko Toshiaki Katada Kenji Kontani Kensuke Miyake TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells
description	Antiviral immune responses involve clustering of plasmacytoid dendritic cells (pDC) in response to endosomal TLR7-mediated sensing of viral RNA. Here the authors show the GTPase Arl8b controls translocation of TLR7+ endosomes to the periphery of the cell via microtubule interactions, thus enabling pDC clustering and type I interferon production.
format	article
author	Shin-Ichiroh Saitoh Fumiko Abe Atsuo Kanno Natsuko Tanimura Yoshiko Mori Saitoh Ryutaro Fukui Takuma Shibata Katsuaki Sato Takeshi Ichinohe Mayumi Hayashi Kazuishi Kubota Hiroko Kozuka-Hata Masaaki Oyama Yorifumi Kikko Toshiaki Katada Kenji Kontani Kensuke Miyake
author_facet	Shin-Ichiroh Saitoh Fumiko Abe Atsuo Kanno Natsuko Tanimura Yoshiko Mori Saitoh Ryutaro Fukui Takuma Shibata Katsuaki Sato Takeshi Ichinohe Mayumi Hayashi Kazuishi Kubota Hiroko Kozuka-Hata Masaaki Oyama Yorifumi Kikko Toshiaki Katada Kenji Kontani Kensuke Miyake
author_sort	Shin-Ichiroh Saitoh
title	TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells
title_short	TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells
title_full	TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells
title_fullStr	TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells
title_full_unstemmed	TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells
title_sort	tlr7 mediated viral recognition results in focal type i interferon secretion by dendritic cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f3a96501c2b548c493e42bf4711580c2
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TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells

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