TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells

TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells

Antiviral immune responses involve clustering of plasmacytoid dendritic cells (pDC) in response to endosomal TLR7-mediated sensing of viral RNA. Here the authors show the GTPase Arl8b controls translocation of TLR7+ endosomes to the periphery of the cell via microtubule interactions, thus enabling p...

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Main Authors: Shin-Ichiroh Saitoh, Fumiko Abe, Atsuo Kanno, Natsuko Tanimura, Yoshiko Mori Saitoh, Ryutaro Fukui, Takuma Shibata, Katsuaki Sato, Takeshi Ichinohe, Mayumi Hayashi, Kazuishi Kubota, Hiroko Kozuka-Hata, Masaaki Oyama, Yorifumi Kikko, Toshiaki Katada, Kenji Kontani, Kensuke Miyake
Format: article
Language:EN
Published: Nature Portfolio 2017
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Science
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Online Access:https://doaj.org/article/f3a96501c2b548c493e42bf4711580c2
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