PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis

Dendritic cells initiate and regulate adaptive immunity and differ according to gut anatomical location. Here the authors show that DC residing in the upper and lower intestines show differential PD-L1 and XCR1 expression and drive specific T cell responses to prevent gut inflammation.

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Autores principales:	Thais G. Moreira, Davide Mangani, Laura M. Cox, Jeffrey Leibowitz, Eduardo. L. C. Lobo, Mariana A. Oliveira, Christian D. Gauthier, Brenda N. Nakagaki, Valerie Willocq, Anya Song, Lydia Guo, David C. A. Lima, Gopal Murugaiyan, Oleg Butovsky, Galina Gabriely, Ana C. Anderson, Rafael M. Rezende, Ana Maria C. Faria, Howard L. Weiner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f3a9efe8e82843f4aa28ca11b29546aa
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spelling	oai:doaj.org-article:f3a9efe8e82843f4aa28ca11b29546aa2021-12-02T19:06:33ZPD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis10.1038/s41467-021-25115-32041-1723https://doaj.org/article/f3a9efe8e82843f4aa28ca11b29546aa2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25115-3https://doaj.org/toc/2041-1723Dendritic cells initiate and regulate adaptive immunity and differ according to gut anatomical location. Here the authors show that DC residing in the upper and lower intestines show differential PD-L1 and XCR1 expression and drive specific T cell responses to prevent gut inflammation.Thais G. MoreiraDavide ManganiLaura M. CoxJeffrey LeibowitzEduardo. L. C. LoboMariana A. OliveiraChristian D. GauthierBrenda N. NakagakiValerie WillocqAnya SongLydia GuoDavid C. A. LimaGopal MurugaiyanOleg ButovskyGalina GabrielyAna C. AndersonRafael M. RezendeAna Maria C. FariaHoward L. WeinerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thais G. Moreira Davide Mangani Laura M. Cox Jeffrey Leibowitz Eduardo. L. C. Lobo Mariana A. Oliveira Christian D. Gauthier Brenda N. Nakagaki Valerie Willocq Anya Song Lydia Guo David C. A. Lima Gopal Murugaiyan Oleg Butovsky Galina Gabriely Ana C. Anderson Rafael M. Rezende Ana Maria C. Faria Howard L. Weiner PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis
description	Dendritic cells initiate and regulate adaptive immunity and differ according to gut anatomical location. Here the authors show that DC residing in the upper and lower intestines show differential PD-L1 and XCR1 expression and drive specific T cell responses to prevent gut inflammation.
format	article
author	Thais G. Moreira Davide Mangani Laura M. Cox Jeffrey Leibowitz Eduardo. L. C. Lobo Mariana A. Oliveira Christian D. Gauthier Brenda N. Nakagaki Valerie Willocq Anya Song Lydia Guo David C. A. Lima Gopal Murugaiyan Oleg Butovsky Galina Gabriely Ana C. Anderson Rafael M. Rezende Ana Maria C. Faria Howard L. Weiner
author_facet	Thais G. Moreira Davide Mangani Laura M. Cox Jeffrey Leibowitz Eduardo. L. C. Lobo Mariana A. Oliveira Christian D. Gauthier Brenda N. Nakagaki Valerie Willocq Anya Song Lydia Guo David C. A. Lima Gopal Murugaiyan Oleg Butovsky Galina Gabriely Ana C. Anderson Rafael M. Rezende Ana Maria C. Faria Howard L. Weiner
author_sort	Thais G. Moreira
title	PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis
title_short	PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis
title_full	PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis
title_fullStr	PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis
title_full_unstemmed	PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis
title_sort	pd-l1+ and xcr1+ dendritic cells are region-specific regulators of gut homeostasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f3a9efe8e82843f4aa28ca11b29546aa
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PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis

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