mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

Glutathione peroxidase 4 (GPX4) inhibits ferroptosis, but protein synthesis is inefficient and costly. Here, the authors reveal that cystine uptake promotes GPX4 synthesis by activating mTORC1 and show that cancer cells are sensitized to ferroptosis by mTORC1 inhibition.

Guardado en:

Detalles Bibliográficos
Autores principales:	Yilei Zhang, Robert V. Swanda, Litong Nie, Xiaoguang Liu, Chao Wang, Hyemin Lee, Guang Lei, Chao Mao, Pranavi Koppula, Weijie Cheng, Jie Zhang, Zhenna Xiao, Li Zhuang, Bingliang Fang, Junjie Chen, Shu-Bing Qian, Boyi Gan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f3ac49c7fb974751a3e7aab804b7d325
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f3ac49c7fb974751a3e7aab804b7d325
record_format	dspace
spelling	oai:doaj.org-article:f3ac49c7fb974751a3e7aab804b7d3252021-12-02T13:35:00ZmTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation10.1038/s41467-021-21841-w2041-1723https://doaj.org/article/f3ac49c7fb974751a3e7aab804b7d3252021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21841-whttps://doaj.org/toc/2041-1723Glutathione peroxidase 4 (GPX4) inhibits ferroptosis, but protein synthesis is inefficient and costly. Here, the authors reveal that cystine uptake promotes GPX4 synthesis by activating mTORC1 and show that cancer cells are sensitized to ferroptosis by mTORC1 inhibition.Yilei ZhangRobert V. SwandaLitong NieXiaoguang LiuChao WangHyemin LeeGuang LeiChao MaoPranavi KoppulaWeijie ChengJie ZhangZhenna XiaoLi ZhuangBingliang FangJunjie ChenShu-Bing QianBoyi GanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yilei Zhang Robert V. Swanda Litong Nie Xiaoguang Liu Chao Wang Hyemin Lee Guang Lei Chao Mao Pranavi Koppula Weijie Cheng Jie Zhang Zhenna Xiao Li Zhuang Bingliang Fang Junjie Chen Shu-Bing Qian Boyi Gan mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
description	Glutathione peroxidase 4 (GPX4) inhibits ferroptosis, but protein synthesis is inefficient and costly. Here, the authors reveal that cystine uptake promotes GPX4 synthesis by activating mTORC1 and show that cancer cells are sensitized to ferroptosis by mTORC1 inhibition.
format	article
author	Yilei Zhang Robert V. Swanda Litong Nie Xiaoguang Liu Chao Wang Hyemin Lee Guang Lei Chao Mao Pranavi Koppula Weijie Cheng Jie Zhang Zhenna Xiao Li Zhuang Bingliang Fang Junjie Chen Shu-Bing Qian Boyi Gan
author_facet	Yilei Zhang Robert V. Swanda Litong Nie Xiaoguang Liu Chao Wang Hyemin Lee Guang Lei Chao Mao Pranavi Koppula Weijie Cheng Jie Zhang Zhenna Xiao Li Zhuang Bingliang Fang Junjie Chen Shu-Bing Qian Boyi Gan
author_sort	Yilei Zhang
title	mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
title_short	mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
title_full	mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
title_fullStr	mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
title_full_unstemmed	mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
title_sort	mtorc1 couples cyst(e)ine availability with gpx4 protein synthesis and ferroptosis regulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f3ac49c7fb974751a3e7aab804b7d325
work_keys_str_mv	AT yileizhang mtorc1couplescysteineavailabilitywithgpx4proteinsynthesisandferroptosisregulation AT robertvswanda mtorc1couplescysteineavailabilitywithgpx4proteinsynthesisandferroptosisregulation AT litongnie mtorc1couplescysteineavailabilitywithgpx4proteinsynthesisandferroptosisregulation AT xiaoguangliu mtorc1couplescysteineavailabilitywithgpx4proteinsynthesisandferroptosisregulation AT chaowang mtorc1couplescysteineavailabilitywithgpx4proteinsynthesisandferroptosisregulation AT hyeminlee mtorc1couplescysteineavailabilitywithgpx4proteinsynthesisandferroptosisregulation AT guanglei mtorc1couplescysteineavailabilitywithgpx4proteinsynthesisandferroptosisregulation AT chaomao mtorc1couplescysteineavailabilitywithgpx4proteinsynthesisandferroptosisregulation AT pranavikoppula mtorc1couplescysteineavailabilitywithgpx4proteinsynthesisandferroptosisregulation AT weijiecheng mtorc1couplescysteineavailabilitywithgpx4proteinsynthesisandferroptosisregulation AT jiezhang mtorc1couplescysteineavailabilitywithgpx4proteinsynthesisandferroptosisregulation AT zhennaxiao mtorc1couplescysteineavailabilitywithgpx4proteinsynthesisandferroptosisregulation AT lizhuang mtorc1couplescysteineavailabilitywithgpx4proteinsynthesisandferroptosisregulation AT bingliangfang mtorc1couplescysteineavailabilitywithgpx4proteinsynthesisandferroptosisregulation AT junjiechen mtorc1couplescysteineavailabilitywithgpx4proteinsynthesisandferroptosisregulation AT shubingqian mtorc1couplescysteineavailabilitywithgpx4proteinsynthesisandferroptosisregulation AT boyigan mtorc1couplescysteineavailabilitywithgpx4proteinsynthesisandferroptosisregulation
_version_	1718392771433201664

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

Ejemplares similares