Disturbed spontaneous brain-activity pattern in patients with optic neuritis using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study

Xin Huang,1,2,* Feng-Qin Cai,3,* Pei-Hong Hu,1 Yu-Lin Zhong,1 Ying Zhang,1 Rong Wei,1 Chong-Gang Pei,1 Fu-Qing Zhou,3 Yi Shao1 1Department of Ophthalmology, Jiangxi Province Clinical Ophthalmology Institute, First Affiliated Hospital of Nanchang University, Nanchang, 2Department of Ophthalmology, F...

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Autores principales:	Huang X, Cai FQ, Hu PH, Zhong YL, Zhang Y, Wei R, Pei CG, Zhou FQ, Shao Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	amplitude of low-frequency fluctuation functional magnetic resonance imaging optic neuritis resting state spontaneous activity visual evoked potential Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f3acc7470e954f28bb3ecfc8d82228e5
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spelling	oai:doaj.org-article:f3acc7470e954f28bb3ecfc8d82228e52021-12-02T02:40:36ZDisturbed spontaneous brain-activity pattern in patients with optic neuritis using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study1178-2021https://doaj.org/article/f3acc7470e954f28bb3ecfc8d82228e52015-12-01T00:00:00Zhttps://www.dovepress.com/disturbed-spontaneous-brain-activity-pattern-in-patients-with-optic-ne-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xin Huang,1,2,* Feng-Qin Cai,3,* Pei-Hong Hu,1 Yu-Lin Zhong,1 Ying Zhang,1 Rong Wei,1 Chong-Gang Pei,1 Fu-Qing Zhou,3 Yi Shao1 1Department of Ophthalmology, Jiangxi Province Clinical Ophthalmology Institute, First Affiliated Hospital of Nanchang University, Nanchang, 2Department of Ophthalmology, First People’s Hospital of Jiujiang, Jiujiang, 3Department of Radiology, First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China *These authors contributed equally to this work Objective: To use the amplitude of low-frequency fluctuation (ALFF) technique to investigate the local features of spontaneous brain activity in optic neuritis (ON) and their relationship with behavioral performance.Materials and methods: Twelve patients with ON (four male, eight female) and twelve age-, sex-, and education status-matched healthy controls (HCs) (four male, eight female) underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. The ALFF technique was used to assess local features of spontaneous brain activity. Correlation analysis was used to explore the relationship between the observed mean ALFF values of the different areas and visual evoked potentials (VEPs) in patients with ON.Results: Compared with HCs, patients with ON had significantly decreased ALFF values in the posterior and anterior lobes of the right cerebellum, right putamen, right inferior frontal gyrus, right insula, right supramarginal gyrus, right inferior parietal lobule, left medial frontal gyrus, left superior temporal gyrus, bilateral anterior cingulate/medial frontal gyrus, and bilateral precuneus, and significantly increased ALFF values in the posterior lobes of the left and right cerebellum, right inferior temporal gyrus, right inferior temporal/fusiform gyrus, left parahippocampal gyrus, left fusiform gyrus, left calcarine fissure, left inferior parietal lobule, and left cuneus. We found negative correlations between the mean ALFF signal value of the left parahippocampal gyrus and the VEP amplitude of the right eye in ON (r=-0.584, P=0.046), and a positive correlation between the mean ALFF signal value of the bilateral precuneus and the best-corrected visual acuity of the left eye (r=0.579, P=0.048) in patients with ON.Conclusion: ON mainly seems to involve dysfunction in the default-mode network, cerebellum, and limbic system, which may reflect the underlying pathologic mechanism of ON. Keywords: ALFF, fMRI, optic neuritis, resting state, spontaneous activity, visual evoked potential Huang XCai FQHu PHZhong YLZhang YWei RPei CGZhou FQShao YDove Medical Pressarticleamplitude of low-frequency fluctuationfunctional magnetic resonance imagingoptic neuritisresting statespontaneous activityvisual evoked potentialNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss Issue 1, Pp 3075-3083 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	amplitude of low-frequency fluctuation functional magnetic resonance imaging optic neuritis resting state spontaneous activity visual evoked potential Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	amplitude of low-frequency fluctuation functional magnetic resonance imaging optic neuritis resting state spontaneous activity visual evoked potential Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Huang X Cai FQ Hu PH Zhong YL Zhang Y Wei R Pei CG Zhou FQ Shao Y Disturbed spontaneous brain-activity pattern in patients with optic neuritis using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study
description	Xin Huang,1,2,* Feng-Qin Cai,3,* Pei-Hong Hu,1 Yu-Lin Zhong,1 Ying Zhang,1 Rong Wei,1 Chong-Gang Pei,1 Fu-Qing Zhou,3 Yi Shao1 1Department of Ophthalmology, Jiangxi Province Clinical Ophthalmology Institute, First Affiliated Hospital of Nanchang University, Nanchang, 2Department of Ophthalmology, First People’s Hospital of Jiujiang, Jiujiang, 3Department of Radiology, First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China *These authors contributed equally to this work Objective: To use the amplitude of low-frequency fluctuation (ALFF) technique to investigate the local features of spontaneous brain activity in optic neuritis (ON) and their relationship with behavioral performance.Materials and methods: Twelve patients with ON (four male, eight female) and twelve age-, sex-, and education status-matched healthy controls (HCs) (four male, eight female) underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. The ALFF technique was used to assess local features of spontaneous brain activity. Correlation analysis was used to explore the relationship between the observed mean ALFF values of the different areas and visual evoked potentials (VEPs) in patients with ON.Results: Compared with HCs, patients with ON had significantly decreased ALFF values in the posterior and anterior lobes of the right cerebellum, right putamen, right inferior frontal gyrus, right insula, right supramarginal gyrus, right inferior parietal lobule, left medial frontal gyrus, left superior temporal gyrus, bilateral anterior cingulate/medial frontal gyrus, and bilateral precuneus, and significantly increased ALFF values in the posterior lobes of the left and right cerebellum, right inferior temporal gyrus, right inferior temporal/fusiform gyrus, left parahippocampal gyrus, left fusiform gyrus, left calcarine fissure, left inferior parietal lobule, and left cuneus. We found negative correlations between the mean ALFF signal value of the left parahippocampal gyrus and the VEP amplitude of the right eye in ON (r=-0.584, P=0.046), and a positive correlation between the mean ALFF signal value of the bilateral precuneus and the best-corrected visual acuity of the left eye (r=0.579, P=0.048) in patients with ON.Conclusion: ON mainly seems to involve dysfunction in the default-mode network, cerebellum, and limbic system, which may reflect the underlying pathologic mechanism of ON. Keywords: ALFF, fMRI, optic neuritis, resting state, spontaneous activity, visual evoked potential
format	article
author	Huang X Cai FQ Hu PH Zhong YL Zhang Y Wei R Pei CG Zhou FQ Shao Y
author_facet	Huang X Cai FQ Hu PH Zhong YL Zhang Y Wei R Pei CG Zhou FQ Shao Y
author_sort	Huang X
title	Disturbed spontaneous brain-activity pattern in patients with optic neuritis using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study
title_short	Disturbed spontaneous brain-activity pattern in patients with optic neuritis using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study
title_full	Disturbed spontaneous brain-activity pattern in patients with optic neuritis using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study
title_fullStr	Disturbed spontaneous brain-activity pattern in patients with optic neuritis using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study
title_full_unstemmed	Disturbed spontaneous brain-activity pattern in patients with optic neuritis using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study
title_sort	disturbed spontaneous brain-activity pattern in patients with optic neuritis using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/f3acc7470e954f28bb3ecfc8d82228e5
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Disturbed spontaneous brain-activity pattern in patients with optic neuritis using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study

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