Association between High Doses Consumption of Niacin and Type 2 Diabetes

BACKGROUND AND OBJECTIVE: Type 2 diabetes, characterized by insulin resistance, impaired insulin secretion, hyperglycemia and oxidative stress. Increasing prevalence of type 2 diabetes in parallel with expanding of food fortification with niacin has observed in developed and developing countries, so...

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Autores principales:	M Niknam, Z Paknahad
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2012
Materias:	niacin diabetes insulin resistance oxidative stress obesity Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f3ad14cebfe249ec905c2fe7f6f4e9c1
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spelling	oai:doaj.org-article:f3ad14cebfe249ec905c2fe7f6f4e9c12021-11-10T08:53:33ZAssociation between High Doses Consumption of Niacin and Type 2 Diabetes1561-41072251-7170https://doaj.org/article/f3ad14cebfe249ec905c2fe7f6f4e9c12012-11-01T00:00:00Zhttp://jbums.org/article-1-4228-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Type 2 diabetes, characterized by insulin resistance, impaired insulin secretion, hyperglycemia and oxidative stress. Increasing prevalence of type 2 diabetes in parallel with expanding of food fortification with niacin has observed in developed and developing countries, so it is possible that intake of high doses of niacin may play a role as an environmental risk factor in type 2 diabetes. The purpose of the present study was to assess the association between consumption of high doses of niacin and the risk of type 2 diabetes.METHODS: The present study is a literature search in PubMed and Science direct with the use of niacin, diabetes, oxidative stress, insulin resistance and obesity as keywords. The results of animal and human studies published until 2011 in this field were considered. FINDINGS: Niacin by elevation of oxidative stress indices increases insulin resistance and leads to hyperinsulinemia, thereafter, improvement of oxidative stress indices by the antioxidant systems leads to elevation of insulin sensitivity that followed by hypoglycemia. Postprandial hypoglycemia induces excess energy intake and obesity. The elevation of oxidative stress indices, insulin resistance and obesity in long-term by continuous stimulation of pancreatic ? cells can lead to type 2 diabetes.CONCLUSION: Reducing niacin intake through reduction of niacin-rich foods and niacin fortified foods may be a useful preventive and therapeutic intervention in type 2 diabetes.M Niknam,Z PaknahadBabol University of Medical Sciencesarticleniacindiabetesinsulin resistanceoxidative stressobesityMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 6, Pp 45-54 (2012)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	niacin diabetes insulin resistance oxidative stress obesity Medicine R Medicine (General) R5-920
spellingShingle	niacin diabetes insulin resistance oxidative stress obesity Medicine R Medicine (General) R5-920 M Niknam, Z Paknahad Association between High Doses Consumption of Niacin and Type 2 Diabetes
description	BACKGROUND AND OBJECTIVE: Type 2 diabetes, characterized by insulin resistance, impaired insulin secretion, hyperglycemia and oxidative stress. Increasing prevalence of type 2 diabetes in parallel with expanding of food fortification with niacin has observed in developed and developing countries, so it is possible that intake of high doses of niacin may play a role as an environmental risk factor in type 2 diabetes. The purpose of the present study was to assess the association between consumption of high doses of niacin and the risk of type 2 diabetes.METHODS: The present study is a literature search in PubMed and Science direct with the use of niacin, diabetes, oxidative stress, insulin resistance and obesity as keywords. The results of animal and human studies published until 2011 in this field were considered. FINDINGS: Niacin by elevation of oxidative stress indices increases insulin resistance and leads to hyperinsulinemia, thereafter, improvement of oxidative stress indices by the antioxidant systems leads to elevation of insulin sensitivity that followed by hypoglycemia. Postprandial hypoglycemia induces excess energy intake and obesity. The elevation of oxidative stress indices, insulin resistance and obesity in long-term by continuous stimulation of pancreatic ? cells can lead to type 2 diabetes.CONCLUSION: Reducing niacin intake through reduction of niacin-rich foods and niacin fortified foods may be a useful preventive and therapeutic intervention in type 2 diabetes.
format	article
author	M Niknam, Z Paknahad
author_facet	M Niknam, Z Paknahad
author_sort	M Niknam,
title	Association between High Doses Consumption of Niacin and Type 2 Diabetes
title_short	Association between High Doses Consumption of Niacin and Type 2 Diabetes
title_full	Association between High Doses Consumption of Niacin and Type 2 Diabetes
title_fullStr	Association between High Doses Consumption of Niacin and Type 2 Diabetes
title_full_unstemmed	Association between High Doses Consumption of Niacin and Type 2 Diabetes
title_sort	association between high doses consumption of niacin and type 2 diabetes
publisher	Babol University of Medical Sciences
publishDate	2012
url	https://doaj.org/article/f3ad14cebfe249ec905c2fe7f6f4e9c1
work_keys_str_mv	AT mniknam associationbetweenhighdosesconsumptionofniacinandtype2diabetes AT zpaknahad associationbetweenhighdosesconsumptionofniacinandtype2diabetes
_version_	1718440430368980992

Association between High Doses Consumption of Niacin and Type 2 Diabetes

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