The interferon response inhibits HIV particle production by induction of TRIM22.

Treatment of human cells with Type 1 interferons restricts HIV replication. Here we report that the tripartite motif protein TRIM22 is a key mediator. We used transcriptional profiling to identify cellular genes that were induced by interferon treatment and identified TRIM22 as one of the most stron...

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Autores principales: Stephen D Barr, James R Smiley, Frederic D Bushman
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2008
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Acceso en línea:https://doaj.org/article/f3b3335734414ad680f757a4f2b52cf0
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