Clinicopathologic profiling and oncologic outcomes of secretory carcinoma of the breast

Abstract Secretory carcinoma of the breast (SCB) is a rather rare entity of invasive breast cancer, the clinicopathologic characteristics and survival outcomes remain to be elaborated. A retrospective review was conducted in SEER database. A total of 190 SCB patients identified in SEER were eligible...

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Autores principales:	Piguo Gong, Chen Xia, Yifeng Yang, Wang Lei, Weiping Yang, Junhua Yu, Yishun Ji, Lijun Ren, Fugui Ye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f3b40a76f8bc4b22b613e65c7049e9ff
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spelling	oai:doaj.org-article:f3b40a76f8bc4b22b613e65c7049e9ff2021-12-02T16:26:22ZClinicopathologic profiling and oncologic outcomes of secretory carcinoma of the breast10.1038/s41598-021-94351-w2045-2322https://doaj.org/article/f3b40a76f8bc4b22b613e65c7049e9ff2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94351-whttps://doaj.org/toc/2045-2322Abstract Secretory carcinoma of the breast (SCB) is a rather rare entity of invasive breast cancer, the clinicopathologic characteristics and survival outcomes remain to be elaborated. A retrospective review was conducted in SEER database. A total of 190 SCB patients identified in SEER were eligible for inclusion in the analysis. Median age at diagnosis was 56 years (range 2–96 years). Both sexes and bilateral breast could be affected. Intriguingly, the incidence of SCB tended towards to decreasing in recent decades. Small tumor burden was observed with a mean tumor size of 2.13 cm. In a subgroup with sufficient details, positive staining of estrogen receptor (ER) and progesterone receptor (PR) was 58% and 40%, respectively. The vast majority of patients were of well to moderate differentiation (86.86%) and negative regional lymph nodes involvement (70.71%). Nearly half of the patients took radiotherapy and chemotherapy. Seniors were inclined to have an inferior breast cancer specific survival (BCSS) than their younger counterparts (P = 0.018). Patients underwent breast conserving surgery (BCS) and radiotherapy had much better BCSS than its mastectomy counterparts (P = 0.014). Collectively, SCB is a clinical indolent invasive breast cancer with excellent prognosis. BCS in conjunction with radiotherapy would be a rational alternative for this distinct entity.Piguo GongChen XiaYifeng YangWang LeiWeiping YangJunhua YuYishun JiLijun RenFugui YeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Piguo Gong Chen Xia Yifeng Yang Wang Lei Weiping Yang Junhua Yu Yishun Ji Lijun Ren Fugui Ye Clinicopathologic profiling and oncologic outcomes of secretory carcinoma of the breast
description	Abstract Secretory carcinoma of the breast (SCB) is a rather rare entity of invasive breast cancer, the clinicopathologic characteristics and survival outcomes remain to be elaborated. A retrospective review was conducted in SEER database. A total of 190 SCB patients identified in SEER were eligible for inclusion in the analysis. Median age at diagnosis was 56 years (range 2–96 years). Both sexes and bilateral breast could be affected. Intriguingly, the incidence of SCB tended towards to decreasing in recent decades. Small tumor burden was observed with a mean tumor size of 2.13 cm. In a subgroup with sufficient details, positive staining of estrogen receptor (ER) and progesterone receptor (PR) was 58% and 40%, respectively. The vast majority of patients were of well to moderate differentiation (86.86%) and negative regional lymph nodes involvement (70.71%). Nearly half of the patients took radiotherapy and chemotherapy. Seniors were inclined to have an inferior breast cancer specific survival (BCSS) than their younger counterparts (P = 0.018). Patients underwent breast conserving surgery (BCS) and radiotherapy had much better BCSS than its mastectomy counterparts (P = 0.014). Collectively, SCB is a clinical indolent invasive breast cancer with excellent prognosis. BCS in conjunction with radiotherapy would be a rational alternative for this distinct entity.
format	article
author	Piguo Gong Chen Xia Yifeng Yang Wang Lei Weiping Yang Junhua Yu Yishun Ji Lijun Ren Fugui Ye
author_facet	Piguo Gong Chen Xia Yifeng Yang Wang Lei Weiping Yang Junhua Yu Yishun Ji Lijun Ren Fugui Ye
author_sort	Piguo Gong
title	Clinicopathologic profiling and oncologic outcomes of secretory carcinoma of the breast
title_short	Clinicopathologic profiling and oncologic outcomes of secretory carcinoma of the breast
title_full	Clinicopathologic profiling and oncologic outcomes of secretory carcinoma of the breast
title_fullStr	Clinicopathologic profiling and oncologic outcomes of secretory carcinoma of the breast
title_full_unstemmed	Clinicopathologic profiling and oncologic outcomes of secretory carcinoma of the breast
title_sort	clinicopathologic profiling and oncologic outcomes of secretory carcinoma of the breast
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f3b40a76f8bc4b22b613e65c7049e9ff
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Clinicopathologic profiling and oncologic outcomes of secretory carcinoma of the breast

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