Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging

Red-shifted bioluminescence emission is needed to improve deep tissue imaging resolution. Here, the authors develop a click beetle red luciferase mutant and two naphthyl-luciferin substrates, and show the ability of the new luciferin/luciferase pairing for deep tissue multispectral tomography in mic...

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Bibliographic Details
Main Authors:	Mary P. Hall, Carolyn C. Woodroofe, Monika G. Wood, Ivo Que, Moniek van’t Root, Yanto Ridwan, Ce Shi, Thomas A. Kirkland, Lance P. Encell, Keith V. Wood, Clemens Löwik, Laura Mezzanotte
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/f3b823b85af24f64b68c08d10040b682
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spelling	oai:doaj.org-article:f3b823b85af24f64b68c08d10040b6822021-12-02T17:33:18ZClick beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging10.1038/s41467-017-02542-92041-1723https://doaj.org/article/f3b823b85af24f64b68c08d10040b6822018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02542-9https://doaj.org/toc/2041-1723Red-shifted bioluminescence emission is needed to improve deep tissue imaging resolution. Here, the authors develop a click beetle red luciferase mutant and two naphthyl-luciferin substrates, and show the ability of the new luciferin/luciferase pairing for deep tissue multispectral tomography in mice.Mary P. HallCarolyn C. WoodroofeMonika G. WoodIvo QueMoniek van’t RootYanto RidwanCe ShiThomas A. KirklandLance P. EncellKeith V. WoodClemens LöwikLaura MezzanotteNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mary P. Hall Carolyn C. Woodroofe Monika G. Wood Ivo Que Moniek van’t Root Yanto Ridwan Ce Shi Thomas A. Kirkland Lance P. Encell Keith V. Wood Clemens Löwik Laura Mezzanotte Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging
description	Red-shifted bioluminescence emission is needed to improve deep tissue imaging resolution. Here, the authors develop a click beetle red luciferase mutant and two naphthyl-luciferin substrates, and show the ability of the new luciferin/luciferase pairing for deep tissue multispectral tomography in mice.
format	article
author	Mary P. Hall Carolyn C. Woodroofe Monika G. Wood Ivo Que Moniek van’t Root Yanto Ridwan Ce Shi Thomas A. Kirkland Lance P. Encell Keith V. Wood Clemens Löwik Laura Mezzanotte
author_facet	Mary P. Hall Carolyn C. Woodroofe Monika G. Wood Ivo Que Moniek van’t Root Yanto Ridwan Ce Shi Thomas A. Kirkland Lance P. Encell Keith V. Wood Clemens Löwik Laura Mezzanotte
author_sort	Mary P. Hall
title	Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging
title_short	Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging
title_full	Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging
title_fullStr	Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging
title_full_unstemmed	Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging
title_sort	click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f3b823b85af24f64b68c08d10040b682
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Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging

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