Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A

Avian influenza polymerase undergoes host adaptation in order to efficiently replicate in human cells. Here, the authors use NMR spectroscopy and quantitative ensemble modelling to describe the highly dynamic assemblies formed by the human-adapted or avian-adapted C-terminal domains with the respect...

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Auteurs principaux: Aldo R. Camacho-Zarco, Sissy Kalayil, Damien Maurin, Nicola Salvi, Elise Delaforge, Sigrid Milles, Malene Ringkjøbing Jensen, Darren J. Hart, Stephen Cusack, Martin Blackledge
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/f3b9b8f89aab4c209ce56f87f7cfa567
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