Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa

Abstract Anorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell...

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Autores principales:	Jana Freff, Kathrin Schwarte, Lisa Bröker, Judith Bühlmeier, Isabelle Kraft, Dana Öztürk, Anke Hinney, Volker Arolt, Udo Dannlowski, Georg Romer, Bernhard T. Baune, Johannes Hebebrand, Manuel Föcker, Judith Alferink
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f3bc205679ba442ea7f572bacbab22c5
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spelling	oai:doaj.org-article:f3bc205679ba442ea7f572bacbab22c52021-12-02T14:01:36ZAlterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa10.1038/s41598-020-80693-42045-2322https://doaj.org/article/f3bc205679ba442ea7f572bacbab22c52021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80693-4https://doaj.org/toc/2045-2322Abstract Anorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell parameters are also not fully understood. Here we investigated the phenotype of circulating B cell subsets and the relationship with body composition in adolescents with AN before (T0, n = 24) and after 6 weeks (T1, n = 20) of treatment. Using multi-parameter flow cytometry, we found increased percentages of antigen-experienced B cells and plasmablasts in patients with AN compared to healthy controls (n = 20). In contrast, percentages of CD1d+CD5+ B cells and transitional B cells with immunoregulatory roles were reduced at T0 and T1. These B cell frequencies correlated positively with fat mass, fat mass index (FMI), free fat mass index, and body mass index standard deviation score. In addition, scavenger-like receptor CD5 expression levels were downregulated on transitional B cells and correlated with fat mass and FMI in AN. Our findings that regulatory B cell subgroups were reduced in AN and their strong relationship with body composition parameters point toward an impact of immunoregulatory B cells in the pathogenesis of AN.Jana FreffKathrin SchwarteLisa BrökerJudith BühlmeierIsabelle KraftDana ÖztürkAnke HinneyVolker AroltUdo DannlowskiGeorg RomerBernhard T. BauneJohannes HebebrandManuel FöckerJudith AlferinkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jana Freff Kathrin Schwarte Lisa Bröker Judith Bühlmeier Isabelle Kraft Dana Öztürk Anke Hinney Volker Arolt Udo Dannlowski Georg Romer Bernhard T. Baune Johannes Hebebrand Manuel Föcker Judith Alferink Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa
description	Abstract Anorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell parameters are also not fully understood. Here we investigated the phenotype of circulating B cell subsets and the relationship with body composition in adolescents with AN before (T0, n = 24) and after 6 weeks (T1, n = 20) of treatment. Using multi-parameter flow cytometry, we found increased percentages of antigen-experienced B cells and plasmablasts in patients with AN compared to healthy controls (n = 20). In contrast, percentages of CD1d+CD5+ B cells and transitional B cells with immunoregulatory roles were reduced at T0 and T1. These B cell frequencies correlated positively with fat mass, fat mass index (FMI), free fat mass index, and body mass index standard deviation score. In addition, scavenger-like receptor CD5 expression levels were downregulated on transitional B cells and correlated with fat mass and FMI in AN. Our findings that regulatory B cell subgroups were reduced in AN and their strong relationship with body composition parameters point toward an impact of immunoregulatory B cells in the pathogenesis of AN.
format	article
author	Jana Freff Kathrin Schwarte Lisa Bröker Judith Bühlmeier Isabelle Kraft Dana Öztürk Anke Hinney Volker Arolt Udo Dannlowski Georg Romer Bernhard T. Baune Johannes Hebebrand Manuel Föcker Judith Alferink
author_facet	Jana Freff Kathrin Schwarte Lisa Bröker Judith Bühlmeier Isabelle Kraft Dana Öztürk Anke Hinney Volker Arolt Udo Dannlowski Georg Romer Bernhard T. Baune Johannes Hebebrand Manuel Föcker Judith Alferink
author_sort	Jana Freff
title	Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa
title_short	Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa
title_full	Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa
title_fullStr	Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa
title_full_unstemmed	Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa
title_sort	alterations in b cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f3bc205679ba442ea7f572bacbab22c5
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Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa

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