Plasma lipid composition and risk of developing cardiovascular disease.

<h4>Aims</h4>We tested whether characteristic changes of the plasma lipidome in individuals with comparable total lipids level associate with future cardiovascular disease (CVD) outcome and whether 23 validated gene variants associated with coronary artery disease (CAD) affect CVD associ...

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Autores principales:	Celine Fernandez, Marianne Sandin, Julio L Sampaio, Peter Almgren, Krzysztof Narkiewicz, Michal Hoffmann, Thomas Hedner, Björn Wahlstrand, Kai Simons, Andrej Shevchenko, Peter James, Olle Melander
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f3c1638dc78c40abb15c9feaf0729d48
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spelling	oai:doaj.org-article:f3c1638dc78c40abb15c9feaf0729d482021-11-18T08:59:30ZPlasma lipid composition and risk of developing cardiovascular disease.1932-620310.1371/journal.pone.0071846https://doaj.org/article/f3c1638dc78c40abb15c9feaf0729d482013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23967253/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Aims</h4>We tested whether characteristic changes of the plasma lipidome in individuals with comparable total lipids level associate with future cardiovascular disease (CVD) outcome and whether 23 validated gene variants associated with coronary artery disease (CAD) affect CVD associated lipid species.<h4>Methods and results</h4>Screening of the fasted plasma lipidome was performed by top-down shotgun analysis and lipidome compositions compared between incident CVD cases (n = 211) and controls (n = 216) from the prospective population-based MDC study using logistic regression adjusting for Framingham risk factors. Associations with incident CVD were seen for eight lipid species (0.21≤q≤0.23). Each standard deviation unit higher baseline levels of two lysophosphatidylcholine species (LPC), LPC16∶0 and LPC20∶4, was associated with a decreased risk for CVD (P = 0.024-0.028). Sphingomyelin (SM) 38∶2 was associated with increased odds of CVD (P = 0.057). Five triglyceride (TAG) species were associated with protection (P = 0.031-0.049). LPC16∶0 was negatively correlated with the carotid intima-media thickness (P = 0.010) and with HbA1c (P = 0.012) whereas SM38∶2 was positively correlated with LDL-cholesterol (P = 0.0*10(-6)) and the q-values were good (q≤0.03). The risk allele of 8 CAD-associated gene variants showed significant association with the plasma level of several lipid species. However, the q-values were high for many of the associations (0.015≤q≤0.75). Risk allele carriers of 3 CAD-loci had reduced level of LPC16∶0 and/or LPC 20∶4 (P≤0.056).<h4>Conclusion</h4>Our study suggests that CVD development is preceded by reduced levels of LPC16∶0, LPC20∶4 and some specific TAG species and by increased levels of SM38∶2. It also indicates that certain lipid species are intermediate phenotypes between genetic susceptibility and overt CVD. But it is a preliminary study that awaits replication in a larger population because statistical significance was lost for the associations between lipid species and future cardiovascular events when correcting for multiple testing.Celine FernandezMarianne SandinJulio L SampaioPeter AlmgrenKrzysztof NarkiewiczMichal HoffmannThomas HednerBjörn WahlstrandKai SimonsAndrej ShevchenkoPeter JamesOlle MelanderPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e71846 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Celine Fernandez Marianne Sandin Julio L Sampaio Peter Almgren Krzysztof Narkiewicz Michal Hoffmann Thomas Hedner Björn Wahlstrand Kai Simons Andrej Shevchenko Peter James Olle Melander Plasma lipid composition and risk of developing cardiovascular disease.
description	<h4>Aims</h4>We tested whether characteristic changes of the plasma lipidome in individuals with comparable total lipids level associate with future cardiovascular disease (CVD) outcome and whether 23 validated gene variants associated with coronary artery disease (CAD) affect CVD associated lipid species.<h4>Methods and results</h4>Screening of the fasted plasma lipidome was performed by top-down shotgun analysis and lipidome compositions compared between incident CVD cases (n = 211) and controls (n = 216) from the prospective population-based MDC study using logistic regression adjusting for Framingham risk factors. Associations with incident CVD were seen for eight lipid species (0.21≤q≤0.23). Each standard deviation unit higher baseline levels of two lysophosphatidylcholine species (LPC), LPC16∶0 and LPC20∶4, was associated with a decreased risk for CVD (P = 0.024-0.028). Sphingomyelin (SM) 38∶2 was associated with increased odds of CVD (P = 0.057). Five triglyceride (TAG) species were associated with protection (P = 0.031-0.049). LPC16∶0 was negatively correlated with the carotid intima-media thickness (P = 0.010) and with HbA1c (P = 0.012) whereas SM38∶2 was positively correlated with LDL-cholesterol (P = 0.0*10(-6)) and the q-values were good (q≤0.03). The risk allele of 8 CAD-associated gene variants showed significant association with the plasma level of several lipid species. However, the q-values were high for many of the associations (0.015≤q≤0.75). Risk allele carriers of 3 CAD-loci had reduced level of LPC16∶0 and/or LPC 20∶4 (P≤0.056).<h4>Conclusion</h4>Our study suggests that CVD development is preceded by reduced levels of LPC16∶0, LPC20∶4 and some specific TAG species and by increased levels of SM38∶2. It also indicates that certain lipid species are intermediate phenotypes between genetic susceptibility and overt CVD. But it is a preliminary study that awaits replication in a larger population because statistical significance was lost for the associations between lipid species and future cardiovascular events when correcting for multiple testing.
format	article
author	Celine Fernandez Marianne Sandin Julio L Sampaio Peter Almgren Krzysztof Narkiewicz Michal Hoffmann Thomas Hedner Björn Wahlstrand Kai Simons Andrej Shevchenko Peter James Olle Melander
author_facet	Celine Fernandez Marianne Sandin Julio L Sampaio Peter Almgren Krzysztof Narkiewicz Michal Hoffmann Thomas Hedner Björn Wahlstrand Kai Simons Andrej Shevchenko Peter James Olle Melander
author_sort	Celine Fernandez
title	Plasma lipid composition and risk of developing cardiovascular disease.
title_short	Plasma lipid composition and risk of developing cardiovascular disease.
title_full	Plasma lipid composition and risk of developing cardiovascular disease.
title_fullStr	Plasma lipid composition and risk of developing cardiovascular disease.
title_full_unstemmed	Plasma lipid composition and risk of developing cardiovascular disease.
title_sort	plasma lipid composition and risk of developing cardiovascular disease.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f3c1638dc78c40abb15c9feaf0729d48
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Plasma lipid composition and risk of developing cardiovascular disease.

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