SEROLOGICAL VERUS HISTOLOGICAL DIAGNOSIS IN PEDIATRIC CELIAC DISEASE: IS THERE A NEED FOR SMALL BOWEL BIOPSY?

Objective: To evaluate the role of tissue transglutaminase IgA antibody (TTG IgA Ab) in diagnosis of pediatric celiac disease (CD) taking small bowel biopsy as gold standard. Study Design: Cross-sectional study. Place and Duration of Study: Department of Pediatric Gastroenterology, the Childre...

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Autores principales:	Aftab Anwar, Huma Arshad Cheema, Anjum Saeed
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	pediatric celiac disease tissue transglutaminase iga small bowel biopsy Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f3c2e63e7ce54e339b3d4227b4e683d2
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spelling	oai:doaj.org-article:f3c2e63e7ce54e339b3d4227b4e683d22021-12-02T19:03:20ZSEROLOGICAL VERUS HISTOLOGICAL DIAGNOSIS IN PEDIATRIC CELIAC DISEASE: IS THERE A NEED FOR SMALL BOWEL BIOPSY?0030-96482411-8842https://doaj.org/article/f3c2e63e7ce54e339b3d4227b4e683d22021-02-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/6380https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To evaluate the role of tissue transglutaminase IgA antibody (TTG IgA Ab) in diagnosis of pediatric celiac disease (CD) taking small bowel biopsy as gold standard. Study Design: Cross-sectional study. Place and Duration of Study: Department of Pediatric Gastroenterology, the Children’s Hospital & the Institute of Child Health, Lahore, from Jan 2018 to Jun 2018. Methodology: Sixty patients aged 2-18 years, with suspicion of CD, having at least 3 presenting features from chronic diarrhea, malnutrition, short stature, anemia, abdominal distention and digital clubbing, were included. TTG IgA Ab titre, small bowel biopsy (SBB) and histopathology were done in all cases. Results: Of the 60 participants, 22 (36.7%) were male and 38 (63.3%) were female with mean age of 6.56 ± 3.78 years. The calculated sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy are 94.1%, 96.1%, 96.9%, 92.5% & 95% respectively. TTG IgA Ab value more than 90 U/ml corresponds to Marsh 3b or higher grade lesion with 94.73% positive predictive value. Conclusion: There is a strong correlation between TTG titres and degree of duodenal damage in patients suspected of CD. Biopsy can be avoided when TTG level is more than 9 times the manufacturer’s cut off value.Aftab AnwarHuma Arshad CheemaAnjum SaeedArmy Medical College Rawalpindiarticlepediatric celiac diseasetissue transglutaminase igasmall bowel biopsyMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 1, Pp 323-327 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pediatric celiac disease tissue transglutaminase iga small bowel biopsy Medicine R Medicine (General) R5-920
spellingShingle	pediatric celiac disease tissue transglutaminase iga small bowel biopsy Medicine R Medicine (General) R5-920 Aftab Anwar Huma Arshad Cheema Anjum Saeed SEROLOGICAL VERUS HISTOLOGICAL DIAGNOSIS IN PEDIATRIC CELIAC DISEASE: IS THERE A NEED FOR SMALL BOWEL BIOPSY?
description	Objective: To evaluate the role of tissue transglutaminase IgA antibody (TTG IgA Ab) in diagnosis of pediatric celiac disease (CD) taking small bowel biopsy as gold standard. Study Design: Cross-sectional study. Place and Duration of Study: Department of Pediatric Gastroenterology, the Children’s Hospital & the Institute of Child Health, Lahore, from Jan 2018 to Jun 2018. Methodology: Sixty patients aged 2-18 years, with suspicion of CD, having at least 3 presenting features from chronic diarrhea, malnutrition, short stature, anemia, abdominal distention and digital clubbing, were included. TTG IgA Ab titre, small bowel biopsy (SBB) and histopathology were done in all cases. Results: Of the 60 participants, 22 (36.7%) were male and 38 (63.3%) were female with mean age of 6.56 ± 3.78 years. The calculated sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy are 94.1%, 96.1%, 96.9%, 92.5% & 95% respectively. TTG IgA Ab value more than 90 U/ml corresponds to Marsh 3b or higher grade lesion with 94.73% positive predictive value. Conclusion: There is a strong correlation between TTG titres and degree of duodenal damage in patients suspected of CD. Biopsy can be avoided when TTG level is more than 9 times the manufacturer’s cut off value.
format	article
author	Aftab Anwar Huma Arshad Cheema Anjum Saeed
author_facet	Aftab Anwar Huma Arshad Cheema Anjum Saeed
author_sort	Aftab Anwar
title	SEROLOGICAL VERUS HISTOLOGICAL DIAGNOSIS IN PEDIATRIC CELIAC DISEASE: IS THERE A NEED FOR SMALL BOWEL BIOPSY?
title_short	SEROLOGICAL VERUS HISTOLOGICAL DIAGNOSIS IN PEDIATRIC CELIAC DISEASE: IS THERE A NEED FOR SMALL BOWEL BIOPSY?
title_full	SEROLOGICAL VERUS HISTOLOGICAL DIAGNOSIS IN PEDIATRIC CELIAC DISEASE: IS THERE A NEED FOR SMALL BOWEL BIOPSY?
title_fullStr	SEROLOGICAL VERUS HISTOLOGICAL DIAGNOSIS IN PEDIATRIC CELIAC DISEASE: IS THERE A NEED FOR SMALL BOWEL BIOPSY?
title_full_unstemmed	SEROLOGICAL VERUS HISTOLOGICAL DIAGNOSIS IN PEDIATRIC CELIAC DISEASE: IS THERE A NEED FOR SMALL BOWEL BIOPSY?
title_sort	serological verus histological diagnosis in pediatric celiac disease: is there a need for small bowel biopsy?
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/f3c2e63e7ce54e339b3d4227b4e683d2
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SEROLOGICAL VERUS HISTOLOGICAL DIAGNOSIS IN PEDIATRIC CELIAC DISEASE: IS THERE A NEED FOR SMALL BOWEL BIOPSY?

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