Associations between fecal short-chain fatty acids and sleep continuity in older adults with insomnia symptoms

Abstract Insomnia is a disorder characterized by difficulty falling asleep and poor sleep continuity and is associated with increased risks for physical and cognitive decline. Insomnia with short sleep duration is considered the most biologically severe phenotype of the disorder. Evidence suggests t...

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Autores principales:	Faiga Magzal, Carmel Even, Iris Haimov, Maayan Agmon, Kfir Asraf, Tamar Shochat, Snait Tamir
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f3c594c6634d4d6a90bac017232e73dd
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spelling	oai:doaj.org-article:f3c594c6634d4d6a90bac017232e73dd2021-12-02T12:11:28ZAssociations between fecal short-chain fatty acids and sleep continuity in older adults with insomnia symptoms10.1038/s41598-021-83389-52045-2322https://doaj.org/article/f3c594c6634d4d6a90bac017232e73dd2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83389-5https://doaj.org/toc/2045-2322Abstract Insomnia is a disorder characterized by difficulty falling asleep and poor sleep continuity and is associated with increased risks for physical and cognitive decline. Insomnia with short sleep duration is considered the most biologically severe phenotype of the disorder. Evidence suggests that short-chain fatty acids (SCFAs), the main byproducts of fiber fermentation in the gut, may affect sleep via gut–brain communications. This study explores associations between SCFAs and sleep continuity and compares SCFA concentrations in short vs. normal sleep insomnia phenotypes in older adults. Fifty-nine participants with insomnia symptoms (≥ 65 years), completed 2 weeks of objective sleep monitoring (actigraphy), and were divided into short and normal sleep duration phenotypes via cluster analysis. Sleep measures included total sleep time (TST), sleep onset latency (SOL), sleep efficiency (SE), and wake after sleep onset (WASO). Stool samples were collected and fecal SCFA concentrations were determined by gas-chromatography-mass-spectrometry (GCMS). Higher concentrations of acetate, butyrate, and propionate, and total SCFAs, were associated with lower SE and longer SOL after controlling for Body Mass Index (BMI). Concentrations were higher in the short sleep duration phenotype. Age, BMI, TST, and SOL explained 40.7% of the variance in total SCFAs. Findings contribute to understanding pathways along the gut–brain axis and may lead to the use of SCFAs as biomarkers of insomnia phenotypes.Faiga MagzalCarmel EvenIris HaimovMaayan AgmonKfir AsrafTamar ShochatSnait TamirNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Faiga Magzal Carmel Even Iris Haimov Maayan Agmon Kfir Asraf Tamar Shochat Snait Tamir Associations between fecal short-chain fatty acids and sleep continuity in older adults with insomnia symptoms
description	Abstract Insomnia is a disorder characterized by difficulty falling asleep and poor sleep continuity and is associated with increased risks for physical and cognitive decline. Insomnia with short sleep duration is considered the most biologically severe phenotype of the disorder. Evidence suggests that short-chain fatty acids (SCFAs), the main byproducts of fiber fermentation in the gut, may affect sleep via gut–brain communications. This study explores associations between SCFAs and sleep continuity and compares SCFA concentrations in short vs. normal sleep insomnia phenotypes in older adults. Fifty-nine participants with insomnia symptoms (≥ 65 years), completed 2 weeks of objective sleep monitoring (actigraphy), and were divided into short and normal sleep duration phenotypes via cluster analysis. Sleep measures included total sleep time (TST), sleep onset latency (SOL), sleep efficiency (SE), and wake after sleep onset (WASO). Stool samples were collected and fecal SCFA concentrations were determined by gas-chromatography-mass-spectrometry (GCMS). Higher concentrations of acetate, butyrate, and propionate, and total SCFAs, were associated with lower SE and longer SOL after controlling for Body Mass Index (BMI). Concentrations were higher in the short sleep duration phenotype. Age, BMI, TST, and SOL explained 40.7% of the variance in total SCFAs. Findings contribute to understanding pathways along the gut–brain axis and may lead to the use of SCFAs as biomarkers of insomnia phenotypes.
format	article
author	Faiga Magzal Carmel Even Iris Haimov Maayan Agmon Kfir Asraf Tamar Shochat Snait Tamir
author_facet	Faiga Magzal Carmel Even Iris Haimov Maayan Agmon Kfir Asraf Tamar Shochat Snait Tamir
author_sort	Faiga Magzal
title	Associations between fecal short-chain fatty acids and sleep continuity in older adults with insomnia symptoms
title_short	Associations between fecal short-chain fatty acids and sleep continuity in older adults with insomnia symptoms
title_full	Associations between fecal short-chain fatty acids and sleep continuity in older adults with insomnia symptoms
title_fullStr	Associations between fecal short-chain fatty acids and sleep continuity in older adults with insomnia symptoms
title_full_unstemmed	Associations between fecal short-chain fatty acids and sleep continuity in older adults with insomnia symptoms
title_sort	associations between fecal short-chain fatty acids and sleep continuity in older adults with insomnia symptoms
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f3c594c6634d4d6a90bac017232e73dd
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Associations between fecal short-chain fatty acids and sleep continuity in older adults with insomnia symptoms

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