Decreasing auditory input induces neurogenesis impairment in the hippocampus

Abstract Hearing loss is associated with cognitive decline and dementia risk. Sensorineural hearing loss suppresses hippocampal neurogenesis, resulting in cognitive decline. However, the underlying mechanism of impaired neurogenesis and the role of microglial activation and stress responses related...

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Autores principales:	Takaomi Kurioka, Sachiyo Mogi, Taku Yamashita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f3c8644fc6f9421aac6f095eb6ef58bf
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spelling	oai:doaj.org-article:f3c8644fc6f9421aac6f095eb6ef58bf2021-12-02T15:23:00ZDecreasing auditory input induces neurogenesis impairment in the hippocampus10.1038/s41598-020-80218-z2045-2322https://doaj.org/article/f3c8644fc6f9421aac6f095eb6ef58bf2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80218-zhttps://doaj.org/toc/2045-2322Abstract Hearing loss is associated with cognitive decline and dementia risk. Sensorineural hearing loss suppresses hippocampal neurogenesis, resulting in cognitive decline. However, the underlying mechanism of impaired neurogenesis and the role of microglial activation and stress responses related to hearing loss in the hippocampus remains unknown. Using a conductive hearing loss (CHL) model, we investigated whether a decrease in sound level could induce impairment of hippocampal neurogenesis and examined the differences between unilateral CHL (uCHL) and bilateral CHL (bCHL). To establish the CHL mouse model, ears were unilaterally or bilaterally occluded for five weeks by auditory canal ligation. Although hearing thresholds were significantly increased following CHL, CHL mice exhibited no significant loss of spiral ganglion or hippocampal neurons. Hippocampal neurogenesis was significantly and equally decreased in both sides following uCHL. More severe decreases in hippocampal neurogenesis were observed in both sides in bCHL mice compared with that in uCHL mice. Furthermore, microglial invasion significantly increased following CHL. Serum cortisol levels, which indicate stress response, significantly increased following bCHL. Therefore, auditory deprivation could lead to increased microglial invasion and stress responses and might be a risk factor for hippocampal neurogenesis impairment.Takaomi KuriokaSachiyo MogiTaku YamashitaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takaomi Kurioka Sachiyo Mogi Taku Yamashita Decreasing auditory input induces neurogenesis impairment in the hippocampus
description	Abstract Hearing loss is associated with cognitive decline and dementia risk. Sensorineural hearing loss suppresses hippocampal neurogenesis, resulting in cognitive decline. However, the underlying mechanism of impaired neurogenesis and the role of microglial activation and stress responses related to hearing loss in the hippocampus remains unknown. Using a conductive hearing loss (CHL) model, we investigated whether a decrease in sound level could induce impairment of hippocampal neurogenesis and examined the differences between unilateral CHL (uCHL) and bilateral CHL (bCHL). To establish the CHL mouse model, ears were unilaterally or bilaterally occluded for five weeks by auditory canal ligation. Although hearing thresholds were significantly increased following CHL, CHL mice exhibited no significant loss of spiral ganglion or hippocampal neurons. Hippocampal neurogenesis was significantly and equally decreased in both sides following uCHL. More severe decreases in hippocampal neurogenesis were observed in both sides in bCHL mice compared with that in uCHL mice. Furthermore, microglial invasion significantly increased following CHL. Serum cortisol levels, which indicate stress response, significantly increased following bCHL. Therefore, auditory deprivation could lead to increased microglial invasion and stress responses and might be a risk factor for hippocampal neurogenesis impairment.
format	article
author	Takaomi Kurioka Sachiyo Mogi Taku Yamashita
author_facet	Takaomi Kurioka Sachiyo Mogi Taku Yamashita
author_sort	Takaomi Kurioka
title	Decreasing auditory input induces neurogenesis impairment in the hippocampus
title_short	Decreasing auditory input induces neurogenesis impairment in the hippocampus
title_full	Decreasing auditory input induces neurogenesis impairment in the hippocampus
title_fullStr	Decreasing auditory input induces neurogenesis impairment in the hippocampus
title_full_unstemmed	Decreasing auditory input induces neurogenesis impairment in the hippocampus
title_sort	decreasing auditory input induces neurogenesis impairment in the hippocampus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f3c8644fc6f9421aac6f095eb6ef58bf
work_keys_str_mv	AT takaomikurioka decreasingauditoryinputinducesneurogenesisimpairmentinthehippocampus AT sachiyomogi decreasingauditoryinputinducesneurogenesisimpairmentinthehippocampus AT takuyamashita decreasingauditoryinputinducesneurogenesisimpairmentinthehippocampus
_version_	1718387362170404864

Decreasing auditory input induces neurogenesis impairment in the hippocampus

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