New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB

Activation of the complement component 5a (C5a) and nuclear factor κB (NF-κB) signaling is an important feature of myocardial ischemia/reperfusion (I/R) injury and recent studies show that morphine postconditioning (MP) attenuates the myocardial injury. However, the mediating cardioprotective mechan...

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Autores principales:	Tu Rong-Hui, Wang Dong-Xiao, Zhong Guo-Qiang, Meng Jian-Jun, Wen Hong, Jie-Feng, Bi Qi, He Yan
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	morphine postconditioning hsp90 akt c5a nf-κb Medicine R
Acceso en línea:	https://doaj.org/article/f3c9954ccaf74f9fa9eaf9b042022c32
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spelling	oai:doaj.org-article:f3c9954ccaf74f9fa9eaf9b042022c322021-12-05T14:10:55ZNew targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB2391-546310.1515/med-2021-0340https://doaj.org/article/f3c9954ccaf74f9fa9eaf9b042022c322021-10-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0340https://doaj.org/toc/2391-5463Activation of the complement component 5a (C5a) and nuclear factor κB (NF-κB) signaling is an important feature of myocardial ischemia/reperfusion (I/R) injury and recent studies show that morphine postconditioning (MP) attenuates the myocardial injury. However, the mediating cardioprotective mechanisms remain unclear. The present study explores the role and interaction of heat shock protein 90 (HSP90), Akt, C5a, and NF-κB in MP-induced cardioprotection.Tu Rong-HuiWang Dong-XiaoZhong Guo-QiangMeng Jian-JunWen HongJie-FengBi QiHe YanDe Gruyterarticlemorphine postconditioninghsp90aktc5anf-κbMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 1552-1563 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	morphine postconditioning hsp90 akt c5a nf-κb Medicine R
spellingShingle	morphine postconditioning hsp90 akt c5a nf-κb Medicine R Tu Rong-Hui Wang Dong-Xiao Zhong Guo-Qiang Meng Jian-Jun Wen Hong Jie-Feng Bi Qi He Yan New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB
description	Activation of the complement component 5a (C5a) and nuclear factor κB (NF-κB) signaling is an important feature of myocardial ischemia/reperfusion (I/R) injury and recent studies show that morphine postconditioning (MP) attenuates the myocardial injury. However, the mediating cardioprotective mechanisms remain unclear. The present study explores the role and interaction of heat shock protein 90 (HSP90), Akt, C5a, and NF-κB in MP-induced cardioprotection.
format	article
author	Tu Rong-Hui Wang Dong-Xiao Zhong Guo-Qiang Meng Jian-Jun Wen Hong Jie-Feng Bi Qi He Yan
author_facet	Tu Rong-Hui Wang Dong-Xiao Zhong Guo-Qiang Meng Jian-Jun Wen Hong Jie-Feng Bi Qi He Yan
author_sort	Tu Rong-Hui
title	New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB
title_short	New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB
title_full	New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB
title_fullStr	New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB
title_full_unstemmed	New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB
title_sort	new targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: involvement of hsp90/akt and c5a/nf-κb
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/f3c9954ccaf74f9fa9eaf9b042022c32
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New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB

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