Risk Factors for the Mortality in Hospitalized Patients with COVID-19: A Brief Report

The cumulative rate of death of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has necessitated better recognizing the risk factors of the disease and the COVID-19-induced mortality. This cross-sectional study aimed to determine the potential risk factors that predict COVID-19-related mortali...

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Autores principales:	Ramin Sami, Mohammad-Reza Hajian, Babak Amra, Forogh Soltaninejad, Marjan Mansourian, Sam Mirfendereski, Raheleh Sadegh, Nilufar Khademi, Soheila Jalali, Nafiseh Shokri-Mashhadi
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2021
Materias:	covid-19 risk factors mortality medical laboratory science Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f3cca7eef7a744158b37ef52d7fb3ec7
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spelling	oai:doaj.org-article:f3cca7eef7a744158b37ef52d7fb3ec72021-11-09T06:23:38ZRisk Factors for the Mortality in Hospitalized Patients with COVID-19: A Brief Report0253-07161735-368810.30476/ijms.2021.47835https://doaj.org/article/f3cca7eef7a744158b37ef52d7fb3ec72021-11-01T00:00:00Zhttps://ijms.sums.ac.ir/article_47835_fd04ec7d6021820c99b9e5a4f258fb5a.pdfhttps://doaj.org/toc/0253-0716https://doaj.org/toc/1735-3688The cumulative rate of death of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has necessitated better recognizing the risk factors of the disease and the COVID-19-induced mortality. This cross-sectional study aimed to determine the potential risk factors that predict COVID-19-related mortality concentrating on the initial recorded laboratory tests. We extracted admission’s medical records of a total of 136 deaths related to COVID-19 and 272 discharged adult inpatients (≥18 years old) related to four referral centers from February 24th to April 12th, 2020, in Isfahan, Iran, to figure out the relationship between the laboratory findings and mortality beyond demographic and clinical findings. We applied the independent sample t test and a chichi square test with SPSS software to compare the differences between the survivor and non-survivor patients. A P value of less than 0.05 was considered significant. Our results showed that greater length of hospitalization (P≤0.001), pre-existing chronic obstructive pulmonary disease (P≤0.001), high pulse rate, hypoxia (P≤0.001), and high computed tomography scan score (P<0.001), in addition to high values of some laboratory parameters, increase the risk of mortality. Moreover, high neutrophil/lymphocyte ratio (OR, 1.890; 95% CI, 1.074-3.325, P=0.027), increased creatinine levels (OR, 15.488; 95% CI, 0.801-299.479, P=0.07), and elevated potassium levels (OR, 13.400; 95% CI, 1.084-165.618, P=0.043) independently predicted in-hospital death related to COVID-19 infection. These results emphasized the potential role of impaired laboratory parameters for the prognosis of fatal outcomes in adult inpatients.Ramin SamiMohammad-Reza HajianBabak AmraForogh SoltaninejadMarjan MansourianSam MirfendereskiRaheleh SadeghNilufar KhademiSoheila JalaliNafiseh Shokri-MashhadiShiraz University of Medical Sciencesarticlecovid-19risk factorsmortalitymedical laboratory scienceMedicine (General)R5-920ENIranian Journal of Medical Sciences, Vol 46, Iss 6, Pp 487-492 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 risk factors mortality medical laboratory science Medicine (General) R5-920
spellingShingle	covid-19 risk factors mortality medical laboratory science Medicine (General) R5-920 Ramin Sami Mohammad-Reza Hajian Babak Amra Forogh Soltaninejad Marjan Mansourian Sam Mirfendereski Raheleh Sadegh Nilufar Khademi Soheila Jalali Nafiseh Shokri-Mashhadi Risk Factors for the Mortality in Hospitalized Patients with COVID-19: A Brief Report
description	The cumulative rate of death of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has necessitated better recognizing the risk factors of the disease and the COVID-19-induced mortality. This cross-sectional study aimed to determine the potential risk factors that predict COVID-19-related mortality concentrating on the initial recorded laboratory tests. We extracted admission’s medical records of a total of 136 deaths related to COVID-19 and 272 discharged adult inpatients (≥18 years old) related to four referral centers from February 24th to April 12th, 2020, in Isfahan, Iran, to figure out the relationship between the laboratory findings and mortality beyond demographic and clinical findings. We applied the independent sample t test and a chichi square test with SPSS software to compare the differences between the survivor and non-survivor patients. A P value of less than 0.05 was considered significant. Our results showed that greater length of hospitalization (P≤0.001), pre-existing chronic obstructive pulmonary disease (P≤0.001), high pulse rate, hypoxia (P≤0.001), and high computed tomography scan score (P<0.001), in addition to high values of some laboratory parameters, increase the risk of mortality. Moreover, high neutrophil/lymphocyte ratio (OR, 1.890; 95% CI, 1.074-3.325, P=0.027), increased creatinine levels (OR, 15.488; 95% CI, 0.801-299.479, P=0.07), and elevated potassium levels (OR, 13.400; 95% CI, 1.084-165.618, P=0.043) independently predicted in-hospital death related to COVID-19 infection. These results emphasized the potential role of impaired laboratory parameters for the prognosis of fatal outcomes in adult inpatients.
format	article
author	Ramin Sami Mohammad-Reza Hajian Babak Amra Forogh Soltaninejad Marjan Mansourian Sam Mirfendereski Raheleh Sadegh Nilufar Khademi Soheila Jalali Nafiseh Shokri-Mashhadi
author_facet	Ramin Sami Mohammad-Reza Hajian Babak Amra Forogh Soltaninejad Marjan Mansourian Sam Mirfendereski Raheleh Sadegh Nilufar Khademi Soheila Jalali Nafiseh Shokri-Mashhadi
author_sort	Ramin Sami
title	Risk Factors for the Mortality in Hospitalized Patients with COVID-19: A Brief Report
title_short	Risk Factors for the Mortality in Hospitalized Patients with COVID-19: A Brief Report
title_full	Risk Factors for the Mortality in Hospitalized Patients with COVID-19: A Brief Report
title_fullStr	Risk Factors for the Mortality in Hospitalized Patients with COVID-19: A Brief Report
title_full_unstemmed	Risk Factors for the Mortality in Hospitalized Patients with COVID-19: A Brief Report
title_sort	risk factors for the mortality in hospitalized patients with covid-19: a brief report
publisher	Shiraz University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/f3cca7eef7a744158b37ef52d7fb3ec7
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Risk Factors for the Mortality in Hospitalized Patients with COVID-19: A Brief Report

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