Epigenetic Modifications and Therapy in Uveitis
Uveitis is a sight-threatening intraocular inflammation, and the exact pathogenesis of uveitis is not yet clear. Recent studies, including multiple genome-wide association studies (GWASs), have identified genetic variations associated with the onset and progression of different types of uveitis, suc...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:f3cd572027ae4c15b08b8c625414b2ce2021-11-18T05:51:43ZEpigenetic Modifications and Therapy in Uveitis2296-634X10.3389/fcell.2021.758240https://doaj.org/article/f3cd572027ae4c15b08b8c625414b2ce2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.758240/fullhttps://doaj.org/toc/2296-634XUveitis is a sight-threatening intraocular inflammation, and the exact pathogenesis of uveitis is not yet clear. Recent studies, including multiple genome-wide association studies (GWASs), have identified genetic variations associated with the onset and progression of different types of uveitis, such as Vogt–Koyanagi–Harada (VKH) disease and Behcet’s disease (BD). However, epigenetic regulation has been shown to play key roles in the immunoregulation of uveitis, and epigenetic therapies are promising treatments for intraocular inflammation. In this review, we summarize recent advances in identifying epigenetic programs that cooperate with the physiology of intraocular immune responses and the pathology of intraocular inflammation. These attempts to understand the epigenetic mechanisms of uveitis may provide hope for the future development of epigenetic therapies for these devastating intraocular inflammatory conditions.Yanli ZouYanli ZouJing Jing LiWei XueXiangbin KongHucheng DuanYiqun LiLai WeiFrontiers Media S.A.articleuveitisepigenetic regulationDNA methylationmicroRNAsepigenetic therapyBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
uveitis epigenetic regulation DNA methylation microRNAs epigenetic therapy Biology (General) QH301-705.5 |
| spellingShingle |
uveitis epigenetic regulation DNA methylation microRNAs epigenetic therapy Biology (General) QH301-705.5 Yanli Zou Yanli Zou Jing Jing Li Wei Xue Xiangbin Kong Hucheng Duan Yiqun Li Lai Wei Epigenetic Modifications and Therapy in Uveitis |
| description |
Uveitis is a sight-threatening intraocular inflammation, and the exact pathogenesis of uveitis is not yet clear. Recent studies, including multiple genome-wide association studies (GWASs), have identified genetic variations associated with the onset and progression of different types of uveitis, such as Vogt–Koyanagi–Harada (VKH) disease and Behcet’s disease (BD). However, epigenetic regulation has been shown to play key roles in the immunoregulation of uveitis, and epigenetic therapies are promising treatments for intraocular inflammation. In this review, we summarize recent advances in identifying epigenetic programs that cooperate with the physiology of intraocular immune responses and the pathology of intraocular inflammation. These attempts to understand the epigenetic mechanisms of uveitis may provide hope for the future development of epigenetic therapies for these devastating intraocular inflammatory conditions. |
| format |
article |
| author |
Yanli Zou Yanli Zou Jing Jing Li Wei Xue Xiangbin Kong Hucheng Duan Yiqun Li Lai Wei |
| author_facet |
Yanli Zou Yanli Zou Jing Jing Li Wei Xue Xiangbin Kong Hucheng Duan Yiqun Li Lai Wei |
| author_sort |
Yanli Zou |
| title |
Epigenetic Modifications and Therapy in Uveitis |
| title_short |
Epigenetic Modifications and Therapy in Uveitis |
| title_full |
Epigenetic Modifications and Therapy in Uveitis |
| title_fullStr |
Epigenetic Modifications and Therapy in Uveitis |
| title_full_unstemmed |
Epigenetic Modifications and Therapy in Uveitis |
| title_sort |
epigenetic modifications and therapy in uveitis |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/f3cd572027ae4c15b08b8c625414b2ce |
| work_keys_str_mv |
AT yanlizou epigeneticmodificationsandtherapyinuveitis AT yanlizou epigeneticmodificationsandtherapyinuveitis AT jingjingli epigeneticmodificationsandtherapyinuveitis AT weixue epigeneticmodificationsandtherapyinuveitis AT xiangbinkong epigeneticmodificationsandtherapyinuveitis AT huchengduan epigeneticmodificationsandtherapyinuveitis AT yiqunli epigeneticmodificationsandtherapyinuveitis AT laiwei epigeneticmodificationsandtherapyinuveitis |
| _version_ |
1718424765051437056 |