Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice

The polyol pathway, which converts glucose into sorbitol and fructose, is active in chronic conditions like hepatic steatosis and chronic kidney disease. Here, Andres-Hernandoet al. show that fructose production promotes renal injury and fructokinase inhibition protects against kidney damage during...

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Autores principales:	Ana Andres-Hernando, Nanxing Li, Christina Cicerchi, Shinichiro Inaba, Wei Chen, Carlos Roncal-Jimenez, Myphuong T. Le, Michael F. Wempe, Tamara Milagres, Takuji Ishimoto, Mehdi Fini, Takahiko Nakagawa, Richard J. Johnson, Miguel A. Lanaspa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f3cdc5cee4a04d45865650ca82efee0f
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spelling	oai:doaj.org-article:f3cdc5cee4a04d45865650ca82efee0f2021-12-02T15:38:31ZProtective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice10.1038/ncomms141812041-1723https://doaj.org/article/f3cdc5cee4a04d45865650ca82efee0f2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14181https://doaj.org/toc/2041-1723The polyol pathway, which converts glucose into sorbitol and fructose, is active in chronic conditions like hepatic steatosis and chronic kidney disease. Here, Andres-Hernandoet al. show that fructose production promotes renal injury and fructokinase inhibition protects against kidney damage during ischaemic acute kidney disease.Ana Andres-HernandoNanxing LiChristina CicerchiShinichiro InabaWei ChenCarlos Roncal-JimenezMyphuong T. LeMichael F. WempeTamara MilagresTakuji IshimotoMehdi FiniTakahiko NakagawaRichard J. JohnsonMiguel A. LanaspaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ana Andres-Hernando Nanxing Li Christina Cicerchi Shinichiro Inaba Wei Chen Carlos Roncal-Jimenez Myphuong T. Le Michael F. Wempe Tamara Milagres Takuji Ishimoto Mehdi Fini Takahiko Nakagawa Richard J. Johnson Miguel A. Lanaspa Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice
description	The polyol pathway, which converts glucose into sorbitol and fructose, is active in chronic conditions like hepatic steatosis and chronic kidney disease. Here, Andres-Hernandoet al. show that fructose production promotes renal injury and fructokinase inhibition protects against kidney damage during ischaemic acute kidney disease.
format	article
author	Ana Andres-Hernando Nanxing Li Christina Cicerchi Shinichiro Inaba Wei Chen Carlos Roncal-Jimenez Myphuong T. Le Michael F. Wempe Tamara Milagres Takuji Ishimoto Mehdi Fini Takahiko Nakagawa Richard J. Johnson Miguel A. Lanaspa
author_facet	Ana Andres-Hernando Nanxing Li Christina Cicerchi Shinichiro Inaba Wei Chen Carlos Roncal-Jimenez Myphuong T. Le Michael F. Wempe Tamara Milagres Takuji Ishimoto Mehdi Fini Takahiko Nakagawa Richard J. Johnson Miguel A. Lanaspa
author_sort	Ana Andres-Hernando
title	Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice
title_short	Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice
title_full	Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice
title_fullStr	Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice
title_full_unstemmed	Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice
title_sort	protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f3cdc5cee4a04d45865650ca82efee0f
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Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice

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