Survey of pretreatment HIV drug resistance and the genetic transmission networks among HIV-positive individuals in southwestern China, 2014–2020

Abstract Background Pretreatment drug resistance (PDR) can limit the effectiveness of HIV antiretroviral therapy (ART). The aim of this study was to assess the prevalence of PDR among HIV-positive individuals that initiated antiretroviral therapy in 2014–2020 in southwestern China. Methods Consecuti...

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Autores principales:	Xiaoshan Xu, Liuhong Luo, Chang Song, Jianjun Li, Huanhuan Chen, Qiuying Zhu, Guanghua Lan, Shujia Liang, Zhiyong Shen, Zhiqiang Cao, Yi Feng, Lingjie Liao, Hui Xing, Yiming Shao, Yuhua Ruan
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	HIV Pretreatment drug resistance (PDR) Antiretroviral therapy (ART) Drug resistance mutations (DRMs) Genetic transmission networks Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/f3ceeb595f7345d3b0e70ccb0bc98457
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spelling	oai:doaj.org-article:f3ceeb595f7345d3b0e70ccb0bc984572021-11-14T12:44:19ZSurvey of pretreatment HIV drug resistance and the genetic transmission networks among HIV-positive individuals in southwestern China, 2014–202010.1186/s12879-021-06847-51471-2334https://doaj.org/article/f3ceeb595f7345d3b0e70ccb0bc984572021-11-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06847-5https://doaj.org/toc/1471-2334Abstract Background Pretreatment drug resistance (PDR) can limit the effectiveness of HIV antiretroviral therapy (ART). The aim of this study was to assess the prevalence of PDR among HIV-positive individuals that initiated antiretroviral therapy in 2014–2020 in southwestern China. Methods Consecutive cross-sectional surveys were conducted in Qinzhou, Guangxi. We obtained blood samples from individuals who were newly diagnosed with HIV in 2014–2020. PDR and genetic networks analyses were performed by HIV-1 pol sequences using the Stanford HIV-database algorithm and HIV-TRACE, respectively. Univariate and multivariate logistic regression models were used to explore the potential factors associated with PDR. Results In total, 3236 eligible HIV-positive individuals were included. The overall prevalence of PDR was 6.0% (194/3236). The PDR frequency to NNRTI (3.3%) was much higher than that of NRTI (1.7%, p < 0.001) and PI (1.2%, p < 0.001). A multivariate logistic regression analysis revealed that PDR was significantly higher among individuals aged 18–29 (adjusted odds ratio (aOR): 1.79, 95% CI 1.28–2.50) or 30–49 (aOR: 2.82, 95% CI 1.73–4.82), and harboring CRF08_BC (aOR: 3.23, 95% CI 1.58–6.59). A total of 1429 (43.8%) sequences were linked forming transmission clusters ranging in size from 2 to 119 individuals. Twenty-two individuals in 10 clusters had the same drug resistant mutations (DRMs), mostly to NNRTIs (50%, 5/10). Conclusions The overall prevalence of PDR was medium, numerous cases of the same DRMs among genetically linked individuals in networks further illustrated the importance of surveillance studies for mitigating PDR.Xiaoshan XuLiuhong LuoChang SongJianjun LiHuanhuan ChenQiuying ZhuGuanghua LanShujia LiangZhiyong ShenZhiqiang CaoYi FengLingjie LiaoHui XingYiming ShaoYuhua RuanBMCarticleHIVPretreatment drug resistance (PDR)Antiretroviral therapy (ART)Drug resistance mutations (DRMs)Genetic transmission networksInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HIV Pretreatment drug resistance (PDR) Antiretroviral therapy (ART) Drug resistance mutations (DRMs) Genetic transmission networks Infectious and parasitic diseases RC109-216
spellingShingle	HIV Pretreatment drug resistance (PDR) Antiretroviral therapy (ART) Drug resistance mutations (DRMs) Genetic transmission networks Infectious and parasitic diseases RC109-216 Xiaoshan Xu Liuhong Luo Chang Song Jianjun Li Huanhuan Chen Qiuying Zhu Guanghua Lan Shujia Liang Zhiyong Shen Zhiqiang Cao Yi Feng Lingjie Liao Hui Xing Yiming Shao Yuhua Ruan Survey of pretreatment HIV drug resistance and the genetic transmission networks among HIV-positive individuals in southwestern China, 2014–2020
description	Abstract Background Pretreatment drug resistance (PDR) can limit the effectiveness of HIV antiretroviral therapy (ART). The aim of this study was to assess the prevalence of PDR among HIV-positive individuals that initiated antiretroviral therapy in 2014–2020 in southwestern China. Methods Consecutive cross-sectional surveys were conducted in Qinzhou, Guangxi. We obtained blood samples from individuals who were newly diagnosed with HIV in 2014–2020. PDR and genetic networks analyses were performed by HIV-1 pol sequences using the Stanford HIV-database algorithm and HIV-TRACE, respectively. Univariate and multivariate logistic regression models were used to explore the potential factors associated with PDR. Results In total, 3236 eligible HIV-positive individuals were included. The overall prevalence of PDR was 6.0% (194/3236). The PDR frequency to NNRTI (3.3%) was much higher than that of NRTI (1.7%, p < 0.001) and PI (1.2%, p < 0.001). A multivariate logistic regression analysis revealed that PDR was significantly higher among individuals aged 18–29 (adjusted odds ratio (aOR): 1.79, 95% CI 1.28–2.50) or 30–49 (aOR: 2.82, 95% CI 1.73–4.82), and harboring CRF08_BC (aOR: 3.23, 95% CI 1.58–6.59). A total of 1429 (43.8%) sequences were linked forming transmission clusters ranging in size from 2 to 119 individuals. Twenty-two individuals in 10 clusters had the same drug resistant mutations (DRMs), mostly to NNRTIs (50%, 5/10). Conclusions The overall prevalence of PDR was medium, numerous cases of the same DRMs among genetically linked individuals in networks further illustrated the importance of surveillance studies for mitigating PDR.
format	article
author	Xiaoshan Xu Liuhong Luo Chang Song Jianjun Li Huanhuan Chen Qiuying Zhu Guanghua Lan Shujia Liang Zhiyong Shen Zhiqiang Cao Yi Feng Lingjie Liao Hui Xing Yiming Shao Yuhua Ruan
author_facet	Xiaoshan Xu Liuhong Luo Chang Song Jianjun Li Huanhuan Chen Qiuying Zhu Guanghua Lan Shujia Liang Zhiyong Shen Zhiqiang Cao Yi Feng Lingjie Liao Hui Xing Yiming Shao Yuhua Ruan
author_sort	Xiaoshan Xu
title	Survey of pretreatment HIV drug resistance and the genetic transmission networks among HIV-positive individuals in southwestern China, 2014–2020
title_short	Survey of pretreatment HIV drug resistance and the genetic transmission networks among HIV-positive individuals in southwestern China, 2014–2020
title_full	Survey of pretreatment HIV drug resistance and the genetic transmission networks among HIV-positive individuals in southwestern China, 2014–2020
title_fullStr	Survey of pretreatment HIV drug resistance and the genetic transmission networks among HIV-positive individuals in southwestern China, 2014–2020
title_full_unstemmed	Survey of pretreatment HIV drug resistance and the genetic transmission networks among HIV-positive individuals in southwestern China, 2014–2020
title_sort	survey of pretreatment hiv drug resistance and the genetic transmission networks among hiv-positive individuals in southwestern china, 2014–2020
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f3ceeb595f7345d3b0e70ccb0bc98457
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Survey of pretreatment HIV drug resistance and the genetic transmission networks among HIV-positive individuals in southwestern China, 2014–2020

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