Lighting up Individual Organelles With Fluorescent Carbon Dots

Cell organelles play crucial roles in the normal functioning of an organism, therefore the disruption of their operation is associated with diseases and in some cases death. Thus, the detection and monitoring of the activities within these organelles are of great importance. Several probes based on...

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Autores principales:	Haifang Liu, Jiancheng Guo, Aaron Albert Aryee, Linlin Hua, Yuanqiang Sun, Zhaohui Li, Jianbo Liu, Wenxue Tang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	carbon dots organelle targeted cell imaging fluorescence precursors Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f3ceedea8e7a44f3af35065fc6e63ca4
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id	oai:doaj.org-article:f3ceedea8e7a44f3af35065fc6e63ca4
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spelling	oai:doaj.org-article:f3ceedea8e7a44f3af35065fc6e63ca42021-12-01T04:32:28ZLighting up Individual Organelles With Fluorescent Carbon Dots2296-264610.3389/fchem.2021.784851https://doaj.org/article/f3ceedea8e7a44f3af35065fc6e63ca42021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.784851/fullhttps://doaj.org/toc/2296-2646Cell organelles play crucial roles in the normal functioning of an organism, therefore the disruption of their operation is associated with diseases and in some cases death. Thus, the detection and monitoring of the activities within these organelles are of great importance. Several probes based on graphene oxide, small molecules, and other nanomaterials have been developed for targeting specific organelles. Among these materials, organelle-targeted fluorescent probes based on carbon dots have attracted substantial attention in recent years owing to their superior characteristics, which include facile synthesis, good photostability, low cytotoxicity, and high selectivity. The ability of these probes to target specific organelles enables researchers to obtain valuable information for understanding the processes involved in their functions and/or malfunctions and may also aid in effective targeted drug delivery. This review highlights recently reported organelle-specific fluorescent probes based on carbon dots. The precursors of these carbon dots are also discussed because studies have shown that many of the intrinsic properties of these probes originate from the precursor used. An overview of the functions of the discussed organelles, the types of probes used, and their advantages and limitations are also provided. Organelles such as the mitochondria, nucleus, lysosomes, and endoplasmic reticulum have been the central focus of research to date, whereas the Golgi body, centrosome, vesicles, and others have received comparatively little attention. It is therefore the hope of the authors that further studies will be conducted in an effort to design probes with the ability to localize within these less studied organelles so as to fully elucidate the mechanisms underlying their function.Haifang LiuJiancheng GuoAaron Albert AryeeLinlin HuaYuanqiang SunZhaohui LiJianbo LiuWenxue TangFrontiers Media S.A.articlecarbon dotsorganelle targetedcell imagingfluorescenceprecursorsChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carbon dots organelle targeted cell imaging fluorescence precursors Chemistry QD1-999
spellingShingle	carbon dots organelle targeted cell imaging fluorescence precursors Chemistry QD1-999 Haifang Liu Jiancheng Guo Aaron Albert Aryee Linlin Hua Yuanqiang Sun Zhaohui Li Jianbo Liu Wenxue Tang Lighting up Individual Organelles With Fluorescent Carbon Dots
description	Cell organelles play crucial roles in the normal functioning of an organism, therefore the disruption of their operation is associated with diseases and in some cases death. Thus, the detection and monitoring of the activities within these organelles are of great importance. Several probes based on graphene oxide, small molecules, and other nanomaterials have been developed for targeting specific organelles. Among these materials, organelle-targeted fluorescent probes based on carbon dots have attracted substantial attention in recent years owing to their superior characteristics, which include facile synthesis, good photostability, low cytotoxicity, and high selectivity. The ability of these probes to target specific organelles enables researchers to obtain valuable information for understanding the processes involved in their functions and/or malfunctions and may also aid in effective targeted drug delivery. This review highlights recently reported organelle-specific fluorescent probes based on carbon dots. The precursors of these carbon dots are also discussed because studies have shown that many of the intrinsic properties of these probes originate from the precursor used. An overview of the functions of the discussed organelles, the types of probes used, and their advantages and limitations are also provided. Organelles such as the mitochondria, nucleus, lysosomes, and endoplasmic reticulum have been the central focus of research to date, whereas the Golgi body, centrosome, vesicles, and others have received comparatively little attention. It is therefore the hope of the authors that further studies will be conducted in an effort to design probes with the ability to localize within these less studied organelles so as to fully elucidate the mechanisms underlying their function.
format	article
author	Haifang Liu Jiancheng Guo Aaron Albert Aryee Linlin Hua Yuanqiang Sun Zhaohui Li Jianbo Liu Wenxue Tang
author_facet	Haifang Liu Jiancheng Guo Aaron Albert Aryee Linlin Hua Yuanqiang Sun Zhaohui Li Jianbo Liu Wenxue Tang
author_sort	Haifang Liu
title	Lighting up Individual Organelles With Fluorescent Carbon Dots
title_short	Lighting up Individual Organelles With Fluorescent Carbon Dots
title_full	Lighting up Individual Organelles With Fluorescent Carbon Dots
title_fullStr	Lighting up Individual Organelles With Fluorescent Carbon Dots
title_full_unstemmed	Lighting up Individual Organelles With Fluorescent Carbon Dots
title_sort	lighting up individual organelles with fluorescent carbon dots
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f3ceedea8e7a44f3af35065fc6e63ca4
work_keys_str_mv	AT haifangliu lightingupindividualorganelleswithfluorescentcarbondots AT jianchengguo lightingupindividualorganelleswithfluorescentcarbondots AT aaronalbertaryee lightingupindividualorganelleswithfluorescentcarbondots AT linlinhua lightingupindividualorganelleswithfluorescentcarbondots AT yuanqiangsun lightingupindividualorganelleswithfluorescentcarbondots AT zhaohuili lightingupindividualorganelleswithfluorescentcarbondots AT jianboliu lightingupindividualorganelleswithfluorescentcarbondots AT wenxuetang lightingupindividualorganelleswithfluorescentcarbondots
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Lighting up Individual Organelles With Fluorescent Carbon Dots

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