Prevalence and Factors Associated with Microalbuminuria in Pediatric Patients with Type 1 Diabetes Mellitus at a Large Tertiary-Level Hospital in Botswana

Tshireletso Ramaphane,1 Alemayehu M Gezmu,1 Endale Tefera,1 Lesego Gabaitiri,2 Seeletso Nchingane,3 Motlalekgomo Matsheng-Samuel,3 Dipesalema Joel1 1Department of Pediatrics and Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana; 2Department of Statistics, Faculty of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ramaphane T, Gezmu AM, Tefera E, Gabaitiri L, Nchingane S, Matsheng-Samuel M, Joel D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	microalbuminuria diabetic nephropathy type 1 diabetes mellitus pediatrics diabetes Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/f3d0351588ae479f90935efe1d3997af
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f3d0351588ae479f90935efe1d3997af
record_format	dspace
spelling	oai:doaj.org-article:f3d0351588ae479f90935efe1d3997af2021-12-02T17:25:13ZPrevalence and Factors Associated with Microalbuminuria in Pediatric Patients with Type 1 Diabetes Mellitus at a Large Tertiary-Level Hospital in Botswana1178-7007https://doaj.org/article/f3d0351588ae479f90935efe1d3997af2021-11-01T00:00:00Zhttps://www.dovepress.com/prevalence-and-factors-associated-with-microalbuminuria-in-pediatric-p-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Tshireletso Ramaphane,1 Alemayehu M Gezmu,1 Endale Tefera,1 Lesego Gabaitiri,2 Seeletso Nchingane,3 Motlalekgomo Matsheng-Samuel,3 Dipesalema Joel1 1Department of Pediatrics and Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana; 2Department of Statistics, Faculty of Social Sciences, University of Botswana, Gaborone, Botswana; 3Princess Marina Hospital, Department of Pediatrics, Gaborone, BotswanaCorrespondence: Alemayehu M GezmuDepartment of Pediatrics and Adolescent Health, Faculty of Medicine, University of Botswana, Bag UB00713, Gaborone, BotswanaEmail gezmuam@ub.ac.bwIntroduction: Microalbuminuria is considered the earliest sign of diabetic nephropathy among patients with type 1 diabetes mellitus (T1DM). The prevalence of microalbuminuria among African children with T1DM is reported to be high, yet its prevalence and population-specific risk factors in Botswana are not known.Aim: This study aimed to determine the prevalence of microalbuminuria among children and young adults with T1DM in Botswana and identify factors associated with microalbuminuria in this population.Methods: A retrospective cross-sectional study was conducted on 127 T1DM patients aged < 24 years followed at a pediatric endocrinology clinic in Botswana from 2010 to 2017. Clinical, laboratory, and demographic data were collected using chart review and patient surveys. Descriptive statistics were reported as mean and standard deviation for continuous variables, and frequency and percentage for categorical variables. Prevalence of microalbuminuria was calculated as a simple proportion. Group comparison was done using two-sample independent t-test, X2-test, or Fisher’s exact test and logistic regression to assess for associations. Level of significance was set at p< 0.05.Results: There were a total of 71 (55.9%) females. The mean age was 18.7 (± 5) years and mean duration of T1DM was 6.6 (± 4.6) years. Most study participants were of African descent. The prevalence of microalbuminuria was 28.3%. Group comparison revealed gender (p= 0.040), duration of diabetes (p= 0.002), systolic blood pressure (p=0.003), baseline glycated hemoglobin (HbA1c) (p=0.009) and Tanner’s stage (p=008) to be significantly associated with microalbuminuria. On binary logistic regression, only gender (p=0.039) and baseline HbA1c (p=0.039) were independently associated with the presences of microalbuminuria.Conclusion: This study identified a high prevalence of microalbuminuria among children and young adults with T1DM in Botswana and reaffirms the importance of early detection, glycemic control, and regular screening to prevent diabetic nephropathy.Keywords: microalbuminuria, diabetic nephropathy, type 1 diabetes mellitus, pediatrics diabetesRamaphane TGezmu AMTefera EGabaitiri LNchingane SMatsheng-Samuel MJoel DDove Medical Pressarticlemicroalbuminuriadiabetic nephropathytype 1 diabetes mellituspediatrics diabetesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 4415-4422 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microalbuminuria diabetic nephropathy type 1 diabetes mellitus pediatrics diabetes Specialties of internal medicine RC581-951
spellingShingle	microalbuminuria diabetic nephropathy type 1 diabetes mellitus pediatrics diabetes Specialties of internal medicine RC581-951 Ramaphane T Gezmu AM Tefera E Gabaitiri L Nchingane S Matsheng-Samuel M Joel D Prevalence and Factors Associated with Microalbuminuria in Pediatric Patients with Type 1 Diabetes Mellitus at a Large Tertiary-Level Hospital in Botswana
description	Tshireletso Ramaphane,1 Alemayehu M Gezmu,1 Endale Tefera,1 Lesego Gabaitiri,2 Seeletso Nchingane,3 Motlalekgomo Matsheng-Samuel,3 Dipesalema Joel1 1Department of Pediatrics and Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana; 2Department of Statistics, Faculty of Social Sciences, University of Botswana, Gaborone, Botswana; 3Princess Marina Hospital, Department of Pediatrics, Gaborone, BotswanaCorrespondence: Alemayehu M GezmuDepartment of Pediatrics and Adolescent Health, Faculty of Medicine, University of Botswana, Bag UB00713, Gaborone, BotswanaEmail gezmuam@ub.ac.bwIntroduction: Microalbuminuria is considered the earliest sign of diabetic nephropathy among patients with type 1 diabetes mellitus (T1DM). The prevalence of microalbuminuria among African children with T1DM is reported to be high, yet its prevalence and population-specific risk factors in Botswana are not known.Aim: This study aimed to determine the prevalence of microalbuminuria among children and young adults with T1DM in Botswana and identify factors associated with microalbuminuria in this population.Methods: A retrospective cross-sectional study was conducted on 127 T1DM patients aged < 24 years followed at a pediatric endocrinology clinic in Botswana from 2010 to 2017. Clinical, laboratory, and demographic data were collected using chart review and patient surveys. Descriptive statistics were reported as mean and standard deviation for continuous variables, and frequency and percentage for categorical variables. Prevalence of microalbuminuria was calculated as a simple proportion. Group comparison was done using two-sample independent t-test, X2-test, or Fisher’s exact test and logistic regression to assess for associations. Level of significance was set at p< 0.05.Results: There were a total of 71 (55.9%) females. The mean age was 18.7 (± 5) years and mean duration of T1DM was 6.6 (± 4.6) years. Most study participants were of African descent. The prevalence of microalbuminuria was 28.3%. Group comparison revealed gender (p= 0.040), duration of diabetes (p= 0.002), systolic blood pressure (p=0.003), baseline glycated hemoglobin (HbA1c) (p=0.009) and Tanner’s stage (p=008) to be significantly associated with microalbuminuria. On binary logistic regression, only gender (p=0.039) and baseline HbA1c (p=0.039) were independently associated with the presences of microalbuminuria.Conclusion: This study identified a high prevalence of microalbuminuria among children and young adults with T1DM in Botswana and reaffirms the importance of early detection, glycemic control, and regular screening to prevent diabetic nephropathy.Keywords: microalbuminuria, diabetic nephropathy, type 1 diabetes mellitus, pediatrics diabetes
format	article
author	Ramaphane T Gezmu AM Tefera E Gabaitiri L Nchingane S Matsheng-Samuel M Joel D
author_facet	Ramaphane T Gezmu AM Tefera E Gabaitiri L Nchingane S Matsheng-Samuel M Joel D
author_sort	Ramaphane T
title	Prevalence and Factors Associated with Microalbuminuria in Pediatric Patients with Type 1 Diabetes Mellitus at a Large Tertiary-Level Hospital in Botswana
title_short	Prevalence and Factors Associated with Microalbuminuria in Pediatric Patients with Type 1 Diabetes Mellitus at a Large Tertiary-Level Hospital in Botswana
title_full	Prevalence and Factors Associated with Microalbuminuria in Pediatric Patients with Type 1 Diabetes Mellitus at a Large Tertiary-Level Hospital in Botswana
title_fullStr	Prevalence and Factors Associated with Microalbuminuria in Pediatric Patients with Type 1 Diabetes Mellitus at a Large Tertiary-Level Hospital in Botswana
title_full_unstemmed	Prevalence and Factors Associated with Microalbuminuria in Pediatric Patients with Type 1 Diabetes Mellitus at a Large Tertiary-Level Hospital in Botswana
title_sort	prevalence and factors associated with microalbuminuria in pediatric patients with type 1 diabetes mellitus at a large tertiary-level hospital in botswana
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f3d0351588ae479f90935efe1d3997af
work_keys_str_mv	AT ramaphanet prevalenceandfactorsassociatedwithmicroalbuminuriainpediatricpatientswithtype1diabetesmellitusatalargetertiarylevelhospitalinbotswana AT gezmuam prevalenceandfactorsassociatedwithmicroalbuminuriainpediatricpatientswithtype1diabetesmellitusatalargetertiarylevelhospitalinbotswana AT teferae prevalenceandfactorsassociatedwithmicroalbuminuriainpediatricpatientswithtype1diabetesmellitusatalargetertiarylevelhospitalinbotswana AT gabaitiril prevalenceandfactorsassociatedwithmicroalbuminuriainpediatricpatientswithtype1diabetesmellitusatalargetertiarylevelhospitalinbotswana AT nchinganes prevalenceandfactorsassociatedwithmicroalbuminuriainpediatricpatientswithtype1diabetesmellitusatalargetertiarylevelhospitalinbotswana AT matshengsamuelm prevalenceandfactorsassociatedwithmicroalbuminuriainpediatricpatientswithtype1diabetesmellitusatalargetertiarylevelhospitalinbotswana AT joeld prevalenceandfactorsassociatedwithmicroalbuminuriainpediatricpatientswithtype1diabetesmellitusatalargetertiarylevelhospitalinbotswana
_version_	1718380943588196352

Prevalence and Factors Associated with Microalbuminuria in Pediatric Patients with Type 1 Diabetes Mellitus at a Large Tertiary-Level Hospital in Botswana

Ejemplares similares