Low levels of vitamin D in neuromyelitis optica spectrum disorder: association with disease disability.

Patients with autoimmune disorders often have low levels of 25-hydroxyvitamin D [25(OH)D3], which correlates with disability or disease activity. Vitamin D may play a role in neuromyelitis optica (NMO) or NMO spectrum disorder (NMOSD), as an important factor involved in immunological pathways. We in...

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Autores principales:	Ju-Hong Min, Patrick Waters, Angela Vincent, Hye-Jin Cho, Byung-Euk Joo, Sook-Young Woo, Soo-Youn Lee, Hee-Young Shin, Kwang Ho Lee, Byoung Joon Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f3d1bd32f0ec44c0b2f5a00fbd137763
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spelling	oai:doaj.org-article:f3d1bd32f0ec44c0b2f5a00fbd1377632021-11-25T06:01:00ZLow levels of vitamin D in neuromyelitis optica spectrum disorder: association with disease disability.1932-620310.1371/journal.pone.0107274https://doaj.org/article/f3d1bd32f0ec44c0b2f5a00fbd1377632014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0107274https://doaj.org/toc/1932-6203Patients with autoimmune disorders often have low levels of 25-hydroxyvitamin D [25(OH)D3], which correlates with disability or disease activity. Vitamin D may play a role in neuromyelitis optica (NMO) or NMO spectrum disorder (NMOSD), as an important factor involved in immunological pathways. We investigated the relationship between vitamin D levels and disease related disability and clinical activity in patients with NMOSD. Blood samples from 51 patients with NMOSD who were positive for anti-aquaporin4-antibody (AQP4-ab) and 204 healthy controls were collected for 25(OH)D3 measurement. Clinical parameters, including expanded disability status scale (EDSS) score, annualized relapse rate (ARR) and time of blood sampling relative to attack, were determined in patients with NMOSD. We found that 25(OH)D3 levels were significantly lower in patients with NMOSD compared to healthy controls. There was no difference between 25(OH)D3 levels in blood samples taken at relapse or remission, and no association between 25(OH)D3 levels and ARR, but there was an inverse correlation between 25(OH)D3 levels and EDSS scores in patients with NMOSD. It remains to be determined whether low vitamin D levels predispose to NMO and/or modify disease severity, or are secondary to neurological disability. In either case the results could also be of relevance to other neurological diseases such as multiple sclerosis as well as NMO.Ju-Hong MinPatrick WatersAngela VincentHye-Jin ChoByung-Euk JooSook-Young WooSoo-Youn LeeHee-Young ShinKwang Ho LeeByoung Joon KimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e107274 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ju-Hong Min Patrick Waters Angela Vincent Hye-Jin Cho Byung-Euk Joo Sook-Young Woo Soo-Youn Lee Hee-Young Shin Kwang Ho Lee Byoung Joon Kim Low levels of vitamin D in neuromyelitis optica spectrum disorder: association with disease disability.
description	Patients with autoimmune disorders often have low levels of 25-hydroxyvitamin D [25(OH)D3], which correlates with disability or disease activity. Vitamin D may play a role in neuromyelitis optica (NMO) or NMO spectrum disorder (NMOSD), as an important factor involved in immunological pathways. We investigated the relationship between vitamin D levels and disease related disability and clinical activity in patients with NMOSD. Blood samples from 51 patients with NMOSD who were positive for anti-aquaporin4-antibody (AQP4-ab) and 204 healthy controls were collected for 25(OH)D3 measurement. Clinical parameters, including expanded disability status scale (EDSS) score, annualized relapse rate (ARR) and time of blood sampling relative to attack, were determined in patients with NMOSD. We found that 25(OH)D3 levels were significantly lower in patients with NMOSD compared to healthy controls. There was no difference between 25(OH)D3 levels in blood samples taken at relapse or remission, and no association between 25(OH)D3 levels and ARR, but there was an inverse correlation between 25(OH)D3 levels and EDSS scores in patients with NMOSD. It remains to be determined whether low vitamin D levels predispose to NMO and/or modify disease severity, or are secondary to neurological disability. In either case the results could also be of relevance to other neurological diseases such as multiple sclerosis as well as NMO.
format	article
author	Ju-Hong Min Patrick Waters Angela Vincent Hye-Jin Cho Byung-Euk Joo Sook-Young Woo Soo-Youn Lee Hee-Young Shin Kwang Ho Lee Byoung Joon Kim
author_facet	Ju-Hong Min Patrick Waters Angela Vincent Hye-Jin Cho Byung-Euk Joo Sook-Young Woo Soo-Youn Lee Hee-Young Shin Kwang Ho Lee Byoung Joon Kim
author_sort	Ju-Hong Min
title	Low levels of vitamin D in neuromyelitis optica spectrum disorder: association with disease disability.
title_short	Low levels of vitamin D in neuromyelitis optica spectrum disorder: association with disease disability.
title_full	Low levels of vitamin D in neuromyelitis optica spectrum disorder: association with disease disability.
title_fullStr	Low levels of vitamin D in neuromyelitis optica spectrum disorder: association with disease disability.
title_full_unstemmed	Low levels of vitamin D in neuromyelitis optica spectrum disorder: association with disease disability.
title_sort	low levels of vitamin d in neuromyelitis optica spectrum disorder: association with disease disability.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/f3d1bd32f0ec44c0b2f5a00fbd137763
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Low levels of vitamin D in neuromyelitis optica spectrum disorder: association with disease disability.

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