A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state

Stormorken syndrome is associated with the R304W mutation in STIM1, which is a Calcium sensor in the endoplasmic reticulum. Here authors use FRET and electrophysiology to show that R304W induces STIM1 conformational extension by a dual mechanism resulting in constitutive activation of Ca2+ channels.

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Autores principales:	Marc Fahrner, Michael Stadlbauer, Martin Muik, Petr Rathner, Peter Stathopulos, Mitsu Ikura, Norbert Müller, Christoph Romanin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f3d205c02ef7403b8fda99785e3df276
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spelling	oai:doaj.org-article:f3d205c02ef7403b8fda99785e3df2762021-12-02T17:33:06ZA dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state10.1038/s41467-018-03062-w2041-1723https://doaj.org/article/f3d205c02ef7403b8fda99785e3df2762018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03062-whttps://doaj.org/toc/2041-1723Stormorken syndrome is associated with the R304W mutation in STIM1, which is a Calcium sensor in the endoplasmic reticulum. Here authors use FRET and electrophysiology to show that R304W induces STIM1 conformational extension by a dual mechanism resulting in constitutive activation of Ca2+ channels.Marc FahrnerMichael StadlbauerMartin MuikPetr RathnerPeter StathopulosMitsu IkuraNorbert MüllerChristoph RomaninNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marc Fahrner Michael Stadlbauer Martin Muik Petr Rathner Peter Stathopulos Mitsu Ikura Norbert Müller Christoph Romanin A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state
description	Stormorken syndrome is associated with the R304W mutation in STIM1, which is a Calcium sensor in the endoplasmic reticulum. Here authors use FRET and electrophysiology to show that R304W induces STIM1 conformational extension by a dual mechanism resulting in constitutive activation of Ca2+ channels.
format	article
author	Marc Fahrner Michael Stadlbauer Martin Muik Petr Rathner Peter Stathopulos Mitsu Ikura Norbert Müller Christoph Romanin
author_facet	Marc Fahrner Michael Stadlbauer Martin Muik Petr Rathner Peter Stathopulos Mitsu Ikura Norbert Müller Christoph Romanin
author_sort	Marc Fahrner
title	A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state
title_short	A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state
title_full	A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state
title_fullStr	A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state
title_full_unstemmed	A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state
title_sort	dual mechanism promotes switching of the stormorken stim1 r304w mutant into the activated state
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f3d205c02ef7403b8fda99785e3df276
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A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state

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