Sustained inflammation 1.5 years post-stroke is not associated with depression in elderly stroke survivors

Kate Noonan,1,2 Sheila G Crewther,1,2 Leeanne M Carey,2,4 Michaela C Pascoe,5 Thomas Linden2,31School of Psychological Science, La Trobe University, Bundoora, Victoria, Australia; 2Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, Heidelberg, Victoria, Australia; 3Institute...

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Autores principales:	Noonan K, Crewther SG, Carey LM, Pascoe MC, Linden T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Geriatric Inflammatory Ischemia Mood. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/f3d23d08a1e64ffe85b6c3b7602c6117
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spelling	oai:doaj.org-article:f3d23d08a1e64ffe85b6c3b7602c61172021-12-02T06:23:11ZSustained inflammation 1.5 years post-stroke is not associated with depression in elderly stroke survivors1178-1998https://doaj.org/article/f3d23d08a1e64ffe85b6c3b7602c61172013-01-01T00:00:00Zhttps://www.dovepress.com/sustained-inflammation-15-years-post-stroke-is-not-associated-with-dep-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Kate Noonan,1,2 Sheila G Crewther,1,2 Leeanne M Carey,2,4 Michaela C Pascoe,5 Thomas Linden2,31School of Psychological Science, La Trobe University, Bundoora, Victoria, Australia; 2Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, Heidelberg, Victoria, Australia; 3Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; 4Department of Occupational Therapy, School of Allied Health, La Trobe University, Bundoora, Victoria, Australia; 5Brain Sciences Institute, Swinburne University, Melbourne, AustraliaBackground: Depression is common in elderly stroke survivors and has been associated with systemic inflammation. We aimed to investigate an elderly population of Swedish stroke patients for evidence of sustained peripheral inflammation 18 months post-stroke and to identify if inflammation is associated with post-stroke depression at 18 months post-stroke.Methods: The Barthel Index was used to measure the level of impairment in activities of daily living at 3 days post-stroke. Serum concentrations of inflammation markers, ie, C-reactive protein and white cell count, were measured in 149 stroke patients (mean age 81 ± 5.33 years, 35% male) at 18 months post-stroke, and a comparison was made with an age-matched sample of elderly Swedish individuals who had not suffered a stroke. At the same visit, clinical depression was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, Third Edition-Revised criteria. Severity of depression was assessed using the Montgomery-Asberg Depression Rating Scale (MADRS).Results: Mean C-reactive protein and white cell count levels in stroke patients were significantly elevated at 18 months post-stroke compared with population probands. Disability scores were associated with MADRS depression scores, but C-reactive protein and white cell count were not.Conclusion: We found evidence for a sustained peripheral inflammatory response at 18 months post-stroke. C-reactive protein and white cell count were not associated with depression in this study.Keywords: geriatric, inflammatory, ischemia, moodNoonan KCrewther SGCarey LMPascoe MCLinden TDove Medical PressarticleGeriatricInflammatoryIschemiaMood.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 69-74 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatric Inflammatory Ischemia Mood. Geriatrics RC952-954.6
spellingShingle	Geriatric Inflammatory Ischemia Mood. Geriatrics RC952-954.6 Noonan K Crewther SG Carey LM Pascoe MC Linden T Sustained inflammation 1.5 years post-stroke is not associated with depression in elderly stroke survivors
description	Kate Noonan,1,2 Sheila G Crewther,1,2 Leeanne M Carey,2,4 Michaela C Pascoe,5 Thomas Linden2,31School of Psychological Science, La Trobe University, Bundoora, Victoria, Australia; 2Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, Heidelberg, Victoria, Australia; 3Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; 4Department of Occupational Therapy, School of Allied Health, La Trobe University, Bundoora, Victoria, Australia; 5Brain Sciences Institute, Swinburne University, Melbourne, AustraliaBackground: Depression is common in elderly stroke survivors and has been associated with systemic inflammation. We aimed to investigate an elderly population of Swedish stroke patients for evidence of sustained peripheral inflammation 18 months post-stroke and to identify if inflammation is associated with post-stroke depression at 18 months post-stroke.Methods: The Barthel Index was used to measure the level of impairment in activities of daily living at 3 days post-stroke. Serum concentrations of inflammation markers, ie, C-reactive protein and white cell count, were measured in 149 stroke patients (mean age 81 ± 5.33 years, 35% male) at 18 months post-stroke, and a comparison was made with an age-matched sample of elderly Swedish individuals who had not suffered a stroke. At the same visit, clinical depression was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, Third Edition-Revised criteria. Severity of depression was assessed using the Montgomery-Asberg Depression Rating Scale (MADRS).Results: Mean C-reactive protein and white cell count levels in stroke patients were significantly elevated at 18 months post-stroke compared with population probands. Disability scores were associated with MADRS depression scores, but C-reactive protein and white cell count were not.Conclusion: We found evidence for a sustained peripheral inflammatory response at 18 months post-stroke. C-reactive protein and white cell count were not associated with depression in this study.Keywords: geriatric, inflammatory, ischemia, mood
format	article
author	Noonan K Crewther SG Carey LM Pascoe MC Linden T
author_facet	Noonan K Crewther SG Carey LM Pascoe MC Linden T
author_sort	Noonan K
title	Sustained inflammation 1.5 years post-stroke is not associated with depression in elderly stroke survivors
title_short	Sustained inflammation 1.5 years post-stroke is not associated with depression in elderly stroke survivors
title_full	Sustained inflammation 1.5 years post-stroke is not associated with depression in elderly stroke survivors
title_fullStr	Sustained inflammation 1.5 years post-stroke is not associated with depression in elderly stroke survivors
title_full_unstemmed	Sustained inflammation 1.5 years post-stroke is not associated with depression in elderly stroke survivors
title_sort	sustained inflammation 1.5 years post-stroke is not associated with depression in elderly stroke survivors
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/f3d23d08a1e64ffe85b6c3b7602c6117
work_keys_str_mv	AT noonank sustainedinflammation15yearspoststrokeisnotassociatedwithdepressioninelderlystrokesurvivors AT crewthersg sustainedinflammation15yearspoststrokeisnotassociatedwithdepressioninelderlystrokesurvivors AT careylm sustainedinflammation15yearspoststrokeisnotassociatedwithdepressioninelderlystrokesurvivors AT pascoemc sustainedinflammation15yearspoststrokeisnotassociatedwithdepressioninelderlystrokesurvivors AT lindent sustainedinflammation15yearspoststrokeisnotassociatedwithdepressioninelderlystrokesurvivors
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Sustained inflammation 1.5 years post-stroke is not associated with depression in elderly stroke survivors

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