CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF DIABETES-ASSOCIATED OSTEOARTHRITIS

Osteoarthritis (OA) has been shown to be a heterogeneous disease. Diabetes mellitus (DM)associated represents a special OA subtype. Its clinical and immunological characteristics are poorly understood. To assess immune phenotype of the diabetes-associated OA and appropriate relationship between its...

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Autores principales:	I. V. Shirinsky, N. Yu. Kalinovskaya, V. S. Shirinsky
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	type 2 diabetes mellitus osteoarthritis cytokines comorbidity inflammation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f3d7ff7c3b4447028d8d5b33a0b518cb
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spelling	oai:doaj.org-article:f3d7ff7c3b4447028d8d5b33a0b518cb2021-11-18T08:03:44ZCLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF DIABETES-ASSOCIATED OSTEOARTHRITIS1563-06252313-741X10.15789/1563-0625-2015-1-87-92https://doaj.org/article/f3d7ff7c3b4447028d8d5b33a0b518cb2015-03-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/813https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XOsteoarthritis (OA) has been shown to be a heterogeneous disease. Diabetes mellitus (DM)associated represents a special OA subtype. Its clinical and immunological characteristics are poorly understood. To assess immune phenotype of the diabetes-associated OA and appropriate relationship between its clinical manifestations and cytokine concentrations in peripheral blood, we examined 78 patients with generalized OA including 52 patients in experimental group (82.6% females) who exhibited clinical manifestations of OA preceded by DM type II for, at least, 1 year, and 26 OA diabetes-free patients (84.6% females). We found that clinical manifestations of DM-associated OA were associated with increased body weight, more pronounced level of joint pains, longer duration of morning stiffness, decreased functionality of hands and large joints, impaired quality of life and more severe clinical pattern of the illness. Pronounced clinical manifestations in OA patients were more typical to the patients who required insulin therapy. The patients with DM type II-associated OA had elevated levels of proinflammatory (IL-6, IL-18) and reduced serum concentrations of anti-infammatory cytokines (IL-10, adiponectin), thus suggesting more pronounced systemic inflammation in patients of the first group. Concentrations of circulating IL-6 correlated with several functional indexes of OA severity. In conclusion, the DM-associated OA represents a special subtype of osteoarthritis, and deserves further studies of its immune pathogenesis and development of new treatment strategies.I. V. ShirinskyN. Yu. KalinovskayaV. S. ShirinskySPb RAACIarticletype 2 diabetes mellitusosteoarthritiscytokinescomorbidityinflammationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 1, Pp 87-92 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	type 2 diabetes mellitus osteoarthritis cytokines comorbidity inflammation Immunologic diseases. Allergy RC581-607
spellingShingle	type 2 diabetes mellitus osteoarthritis cytokines comorbidity inflammation Immunologic diseases. Allergy RC581-607 I. V. Shirinsky N. Yu. Kalinovskaya V. S. Shirinsky CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF DIABETES-ASSOCIATED OSTEOARTHRITIS
description	Osteoarthritis (OA) has been shown to be a heterogeneous disease. Diabetes mellitus (DM)associated represents a special OA subtype. Its clinical and immunological characteristics are poorly understood. To assess immune phenotype of the diabetes-associated OA and appropriate relationship between its clinical manifestations and cytokine concentrations in peripheral blood, we examined 78 patients with generalized OA including 52 patients in experimental group (82.6% females) who exhibited clinical manifestations of OA preceded by DM type II for, at least, 1 year, and 26 OA diabetes-free patients (84.6% females). We found that clinical manifestations of DM-associated OA were associated with increased body weight, more pronounced level of joint pains, longer duration of morning stiffness, decreased functionality of hands and large joints, impaired quality of life and more severe clinical pattern of the illness. Pronounced clinical manifestations in OA patients were more typical to the patients who required insulin therapy. The patients with DM type II-associated OA had elevated levels of proinflammatory (IL-6, IL-18) and reduced serum concentrations of anti-infammatory cytokines (IL-10, adiponectin), thus suggesting more pronounced systemic inflammation in patients of the first group. Concentrations of circulating IL-6 correlated with several functional indexes of OA severity. In conclusion, the DM-associated OA represents a special subtype of osteoarthritis, and deserves further studies of its immune pathogenesis and development of new treatment strategies.
format	article
author	I. V. Shirinsky N. Yu. Kalinovskaya V. S. Shirinsky
author_facet	I. V. Shirinsky N. Yu. Kalinovskaya V. S. Shirinsky
author_sort	I. V. Shirinsky
title	CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF DIABETES-ASSOCIATED OSTEOARTHRITIS
title_short	CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF DIABETES-ASSOCIATED OSTEOARTHRITIS
title_full	CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF DIABETES-ASSOCIATED OSTEOARTHRITIS
title_fullStr	CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF DIABETES-ASSOCIATED OSTEOARTHRITIS
title_full_unstemmed	CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF DIABETES-ASSOCIATED OSTEOARTHRITIS
title_sort	clinical and immunological characteristics of diabetes-associated osteoarthritis
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/f3d7ff7c3b4447028d8d5b33a0b518cb
work_keys_str_mv	AT ivshirinsky clinicalandimmunologicalcharacteristicsofdiabetesassociatedosteoarthritis AT nyukalinovskaya clinicalandimmunologicalcharacteristicsofdiabetesassociatedosteoarthritis AT vsshirinsky clinicalandimmunologicalcharacteristicsofdiabetesassociatedosteoarthritis
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CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF DIABETES-ASSOCIATED OSTEOARTHRITIS

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