Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling

The molecular mechanisms regulating adult neural stem/progenitor cell differentiation following damage of the central nervous system are unclear. Here, the authors show that fibrinogen is a regulator of the adult neural stem/progenitor cell switch from neurogenesis to astrogenesis in a model of stro...

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Autores principales: Lauriane Pous, Sachin S. Deshpande, Suvra Nath, Szilvia Mezey, Subash C. Malik, Sebastian Schildge, Christian Bohrer, Könül Topp, Dietmar Pfeifer, Francisco Fernández-Klett, Soroush Doostkam, Dennis K. Galanakis, Verdon Taylor, Katerina Akassoglou, Christian Schachtrup
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/f3d973f0777646bfaf11ff6400d0b81e
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Sumario:The molecular mechanisms regulating adult neural stem/progenitor cell differentiation following damage of the central nervous system are unclear. Here, the authors show that fibrinogen is a regulator of the adult neural stem/progenitor cell switch from neurogenesis to astrogenesis in a model of stroke