Thrombotic Microangiopathy Associated with Gemcitabine in Non-Small Cell Lung Cancer: A Case Report

A 69-year-old man with refractory lung adenocarcinoma was treated with gemcitabine and vinorelbine. Dyspnea and hypertension developed after the 17th cycle of chemotherapy. Laboratory findings revealed intravascular hemolysis and renal dysfunction. Thrombotic microangiopathy (TMA) was confirmed by r...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tadahiro Kuribayashi, Keiichi Fujiwara, Kiriko Onishi, Sho Mitsumune, Yuki Takigawa, Hiromi Watanabe, Kenichiro Kudo, Akiko Sato, Ken Sato, Masashi Kitagawa, Kosuke Ota, Yoko Shinno, Takuo Shibayama
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	thrombotic microangiopathy non-small cell lung cancer gemcitabine autopsy plasmapheresis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f3d9d886e5944ca7bca017d964ba723e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f3d9d886e5944ca7bca017d964ba723e
record_format	dspace
spelling	oai:doaj.org-article:f3d9d886e5944ca7bca017d964ba723e2021-12-02T12:40:23ZThrombotic Microangiopathy Associated with Gemcitabine in Non-Small Cell Lung Cancer: A Case Report1662-657510.1159/000520484https://doaj.org/article/f3d9d886e5944ca7bca017d964ba723e2021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520484https://doaj.org/toc/1662-6575A 69-year-old man with refractory lung adenocarcinoma was treated with gemcitabine and vinorelbine. Dyspnea and hypertension developed after the 17th cycle of chemotherapy. Laboratory findings revealed intravascular hemolysis and renal dysfunction. Thrombotic microangiopathy (TMA) was confirmed by renal biopsy. Antihypertensive and steroid therapies were ineffective. After plasmapheresis, intravascular hemolysis and renal dysfunction gradually improved. However, the disease progressed, and he died 6 months after TMA diagnosis. Autopsy revealed similar pathological findings to those of the renal biopsy. It is important to discontinue gemcitabine at the onset of TMA and consider TMA when using gemcitabine for long periods.Tadahiro KuribayashiKeiichi FujiwaraKiriko OnishiSho MitsumuneYuki TakigawaHiromi WatanabeKenichiro KudoAkiko SatoKen SatoMasashi KitagawaKosuke OtaYoko ShinnoTakuo ShibayamaKarger Publishersarticlethrombotic microangiopathynon-small cell lung cancergemcitabineautopsyplasmapheresisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCase Reports in Oncology, Vol 14, Iss 3, Pp 1712-1718 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thrombotic microangiopathy non-small cell lung cancer gemcitabine autopsy plasmapheresis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	thrombotic microangiopathy non-small cell lung cancer gemcitabine autopsy plasmapheresis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Tadahiro Kuribayashi Keiichi Fujiwara Kiriko Onishi Sho Mitsumune Yuki Takigawa Hiromi Watanabe Kenichiro Kudo Akiko Sato Ken Sato Masashi Kitagawa Kosuke Ota Yoko Shinno Takuo Shibayama Thrombotic Microangiopathy Associated with Gemcitabine in Non-Small Cell Lung Cancer: A Case Report
description	A 69-year-old man with refractory lung adenocarcinoma was treated with gemcitabine and vinorelbine. Dyspnea and hypertension developed after the 17th cycle of chemotherapy. Laboratory findings revealed intravascular hemolysis and renal dysfunction. Thrombotic microangiopathy (TMA) was confirmed by renal biopsy. Antihypertensive and steroid therapies were ineffective. After plasmapheresis, intravascular hemolysis and renal dysfunction gradually improved. However, the disease progressed, and he died 6 months after TMA diagnosis. Autopsy revealed similar pathological findings to those of the renal biopsy. It is important to discontinue gemcitabine at the onset of TMA and consider TMA when using gemcitabine for long periods.
format	article
author	Tadahiro Kuribayashi Keiichi Fujiwara Kiriko Onishi Sho Mitsumune Yuki Takigawa Hiromi Watanabe Kenichiro Kudo Akiko Sato Ken Sato Masashi Kitagawa Kosuke Ota Yoko Shinno Takuo Shibayama
author_facet	Tadahiro Kuribayashi Keiichi Fujiwara Kiriko Onishi Sho Mitsumune Yuki Takigawa Hiromi Watanabe Kenichiro Kudo Akiko Sato Ken Sato Masashi Kitagawa Kosuke Ota Yoko Shinno Takuo Shibayama
author_sort	Tadahiro Kuribayashi
title	Thrombotic Microangiopathy Associated with Gemcitabine in Non-Small Cell Lung Cancer: A Case Report
title_short	Thrombotic Microangiopathy Associated with Gemcitabine in Non-Small Cell Lung Cancer: A Case Report
title_full	Thrombotic Microangiopathy Associated with Gemcitabine in Non-Small Cell Lung Cancer: A Case Report
title_fullStr	Thrombotic Microangiopathy Associated with Gemcitabine in Non-Small Cell Lung Cancer: A Case Report
title_full_unstemmed	Thrombotic Microangiopathy Associated with Gemcitabine in Non-Small Cell Lung Cancer: A Case Report
title_sort	thrombotic microangiopathy associated with gemcitabine in non-small cell lung cancer: a case report
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/f3d9d886e5944ca7bca017d964ba723e
work_keys_str_mv	AT tadahirokuribayashi thromboticmicroangiopathyassociatedwithgemcitabineinnonsmallcelllungcanceracasereport AT keiichifujiwara thromboticmicroangiopathyassociatedwithgemcitabineinnonsmallcelllungcanceracasereport AT kirikoonishi thromboticmicroangiopathyassociatedwithgemcitabineinnonsmallcelllungcanceracasereport AT shomitsumune thromboticmicroangiopathyassociatedwithgemcitabineinnonsmallcelllungcanceracasereport AT yukitakigawa thromboticmicroangiopathyassociatedwithgemcitabineinnonsmallcelllungcanceracasereport AT hiromiwatanabe thromboticmicroangiopathyassociatedwithgemcitabineinnonsmallcelllungcanceracasereport AT kenichirokudo thromboticmicroangiopathyassociatedwithgemcitabineinnonsmallcelllungcanceracasereport AT akikosato thromboticmicroangiopathyassociatedwithgemcitabineinnonsmallcelllungcanceracasereport AT kensato thromboticmicroangiopathyassociatedwithgemcitabineinnonsmallcelllungcanceracasereport AT masashikitagawa thromboticmicroangiopathyassociatedwithgemcitabineinnonsmallcelllungcanceracasereport AT kosukeota thromboticmicroangiopathyassociatedwithgemcitabineinnonsmallcelllungcanceracasereport AT yokoshinno thromboticmicroangiopathyassociatedwithgemcitabineinnonsmallcelllungcanceracasereport AT takuoshibayama thromboticmicroangiopathyassociatedwithgemcitabineinnonsmallcelllungcanceracasereport
_version_	1718393776671555584

Thrombotic Microangiopathy Associated with Gemcitabine in Non-Small Cell Lung Cancer: A Case Report

Ejemplares similares