The concurrence of DNA methylation and demethylation is associated with transcription regulation

The concurrence of DNA methylation and demethylation is associated with transcription regulation

The global pattern of the mammalian methylome is formed by changes in methylation and demethylation. Here the authors describe a metric methylation concurrence that measures the ratio of unmethylated CpGs inside the partially methylated reads and show that methylation concurrence is associated with...

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Autores principales: Jiejun Shi, Jianfeng Xu, Yiling Elaine Chen, Jason Sheng Li, Ya Cui, Lanlan Shen, Jingyi Jessica Li, Wei Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f3d9fde93e384899b5a04283a78052d0
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spelling oai:doaj.org-article:f3d9fde93e384899b5a04283a78052d02021-12-02T19:12:29ZThe concurrence of DNA methylation and demethylation is associated with transcription regulation10.1038/s41467-021-25521-72041-1723https://doaj.org/article/f3d9fde93e384899b5a04283a78052d02021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25521-7https://doaj.org/toc/2041-1723The global pattern of the mammalian methylome is formed by changes in methylation and demethylation. Here the authors describe a metric methylation concurrence that measures the ratio of unmethylated CpGs inside the partially methylated reads and show that methylation concurrence is associated with epigenetically regulated tumour suppressor genes.Jiejun ShiJianfeng XuYiling Elaine ChenJason Sheng LiYa CuiLanlan ShenJingyi Jessica LiWei LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jiejun Shi
Jianfeng Xu
Yiling Elaine Chen
Jason Sheng Li
Ya Cui
Lanlan Shen
Jingyi Jessica Li
Wei Li
The concurrence of DNA methylation and demethylation is associated with transcription regulation
description The global pattern of the mammalian methylome is formed by changes in methylation and demethylation. Here the authors describe a metric methylation concurrence that measures the ratio of unmethylated CpGs inside the partially methylated reads and show that methylation concurrence is associated with epigenetically regulated tumour suppressor genes.
format article
author Jiejun Shi
Jianfeng Xu
Yiling Elaine Chen
Jason Sheng Li
Ya Cui
Lanlan Shen
Jingyi Jessica Li
Wei Li
author_facet Jiejun Shi
Jianfeng Xu
Yiling Elaine Chen
Jason Sheng Li
Ya Cui
Lanlan Shen
Jingyi Jessica Li
Wei Li
author_sort Jiejun Shi
title The concurrence of DNA methylation and demethylation is associated with transcription regulation
title_short The concurrence of DNA methylation and demethylation is associated with transcription regulation
title_full The concurrence of DNA methylation and demethylation is associated with transcription regulation
title_fullStr The concurrence of DNA methylation and demethylation is associated with transcription regulation
title_full_unstemmed The concurrence of DNA methylation and demethylation is associated with transcription regulation
title_sort concurrence of dna methylation and demethylation is associated with transcription regulation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/f3d9fde93e384899b5a04283a78052d0
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