Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism

Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism

ABCG2 is a transporter contributing to multidrug resistance of cancer cells. Here, structures of human ABCG2 under turnover conditions reveal distinct conformational states, provide insight into the transport cycle and suggest a mechanism of discrimination between substrates and inhibitors.

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Autores principales: Qin Yu, Dongchun Ni, Julia Kowal, Ioannis Manolaridis, Scott M. Jackson, Henning Stahlberg, Kaspar P. Locher
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/f3dae0a3a07a42eb9d31262f294b2505
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